MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia. - Wikidata - wikimedia - TriplyDB

MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia.

MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia.

http://www.wikidata.org/entity/Q36560798

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Protein phosphorylation cascades associated with methamphetamine-induced glial activation.Activation of transcription factors AP-1 and NF-kappa B in murine Chagasic myocarditis Activation of Erk and JNK MAPK pathways by acute swim stress in rat brain regions Neuroprotective role of a brain-enriched tyrosine phosphatase, STEP, in focal cerebral ischemia Hydrogen sulfide protects against chemical hypoxia-induced injury by inhibiting ROS-activated ERK1/2 and p38MAPK signaling pathways in PC12 cells Salvinorin A administration after global cerebral hypoxia/ischemia preserves cerebrovascular autoregulation via kappa opioid receptor in piglets Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line Zonisamide Enhances Neurite Elongation of Primary Motor Neurons and Facilitates Peripheral Nerve Regeneration In Vitro and in a Mouse Model Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades Mechanical trauma induces rapid astroglial activation of ERK/MAP kinase: Evidence for a paracrine signal.Isoflurane preconditioning increases B-cell lymphoma-2 expression and reduces cytochrome c release from the mitochondria in the ischemic penumbra of rat brain.Postconditioning with isoflurane reduced ischemia-induced brain injury in rats.Alteration of MAP kinase pathways after transient forebrain ischemia.Piroxicam and NS-398 rescue neurones from hypoxia/reoxygenation damage by a mechanism independent of cyclo-oxygenase inhibition.Enhanced expressions of microvascular smooth muscle receptors after focal cerebral ischemia occur via the MAPK MEK/ERK pathway.Targeting protein kinases in central nervous system disorders Role of protein phosphatases and mitochondria in the neuroprotective effects of estrogens.Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model SNP improves cerebral hemodynamics during normotension but fails to prevent sex dependent impaired cerebral autoregulation during hypotension after brain injury.Neuroprotective effects of total steroid saponins on cerebral ischemia injuries in an animal model of focal ischemia/reperfusion Estrogen receptor independent neurotoxic mechanism of bisphenol A, an environmental estrogen.Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration Helicobacter pylori induces ERK-dependent formation of a phospho-c-Fos c-Jun activator protein-1 complex that causes apoptosis in macrophages Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia PAI-1-derived peptide EEIIMD prevents impairment of cerebrovasodilation by augmenting p38 MAPK upregulation after cerebral hypoxia/ischemia.Evaluation of a luciferase-based reporter assay as a screen for inhibitors of estrogen-ERα-induced proliferation of breast cancer cells.Pharmacologic resuscitation promotes survival and attenuates hemorrhage-induced activation of extracellular signal-regulated kinase 1/2.Cytosolic phospholipase A2 alpha amplifies early cyclooxygenase-2 expression, oxidative stress and MAP kinase phosphorylation after cerebral ischemia in mice.p90 activation contributes to cerebral ischemic damage via phosphorylation of Na+/H+ exchanger isoform 1.Neuroprotective effect of the traditional Chinese herbal formula Tongxinluo: a PET imaging study in rats.Zinc and the ERK kinases in the developing brain.Suppressive regulatory T cell activity is potentiated by glycogen synthase kinase 3{beta} inhibition Neuronal necrosis is regulated by a conserved chromatin-modifying cascade.An L-type calcium channel agonist, bay K8644, extends the window of intervention against ischemic neuronal injury.Mechanisms and prospects of ischemic tolerance induced by cerebral preconditioning.Gas1 is related to the glial cell-derived neurotrophic factor family receptors alpha and regulates Ret signaling.tPA contributes to impairment of ATP and Ca sensitive K channel mediated cerebrovasodilation after hypoxia/ischemia through upregulation of ERK MAPK.Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2.NR2B-NMDA receptor-mediated increases in intracellular Ca2+ concentration regulate the tyrosine phosphatase, STEP, and ERK MAP kinase signaling Role of mitogen- and stress-activated kinases in ischemic injury.

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P2860

MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia.

http://www.wikidata.org/entity/Q36560798

description

1999 nî lūn-bûn

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年论文

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1999年论文

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1999年论文

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name

MEK1 protein kinase inhibition ...... from focal cerebral ischemia.

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MEK1 protein kinase inhibition ...... from focal cerebral ischemia.

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type

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MEK1 protein kinase inhibition ...... from focal cerebral ischemia.

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MEK1 protein kinase inhibition ...... from focal cerebral ischemia.

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prefLabel

MEK1 protein kinase inhibition ...... from focal cerebral ischemia.

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MEK1 protein kinase inhibition ...... from focal cerebral ischemia.

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Proceedings of the National Academy of Sciences of the United States of America

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MEK1 protein kinase inhibition ...... from focal cerebral ischemia.

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P2093

A Alessandrini

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J V Bonventre

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M A Moskowitz

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S Namura

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P2860

cPLA2 is phosphorylated and activated by MAP kinase

The MAPK signaling cascade

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage.

Neuroprotective action of cycloheximide involves induction of bcl-2 and antioxidant pathways

Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity.

The search for physiological substrates of MAP and SAP kinases in mammalian cells.

Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions.

Excitatory amino acids, growth factors, and calcium: a teeter-totter model for neural plasticity and degeneration.

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12866-12869

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10.1073/PNAS.96.22.12866

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22

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96

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12764666

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10536014

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cerebral infarction

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23136

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