Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1
about
Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteinsHuman TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2FMutations of the Drosophila dDP, dE2F, and cyclin E genes reveal distinct roles for the E2F-DP transcription factor and cyclin E during the G1-S transition.TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells.Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DPInduction of S-phase entry by E2F transcription factors depends on their nuclear localizationUnusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6Active nuclear import and export pathways regulate E2F-5 subcellular localizationThe proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1The DP-1 transcription factor is required for keratinocyte growth and epidermal stratificationInhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the ratLoss of dE2F compromises mitochondrial functionHuman SWI-SNF component BRG1 represses transcription of the c-fos geneInhibition of mammalian cell proliferation by genetically selected peptide aptamers that functionally antagonize E2F activity.Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death.Context-dependent requirement for dE2F during oncogenic proliferationCyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins.Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor.Histone deacetylases, transcriptional control, and cancer.Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis.Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a)Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa-DPa transcription factor.The RIP140 gene is a transcriptional target of E2F1.Functional antagonism between E2F family membersMutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program.PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A.Collaborative role of E2F transcriptional activity and G1 cyclindependent kinase activity in the induction of S phase.p110 CUX1 cooperates with E2F transcription factors in the transcriptional activation of cell cycle-regulated genes.A small-molecule E2F inhibitor blocks growth in a melanoma culture model.Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function.Identification of E2F target genes that are rate limiting for dE2F1-dependent cell proliferationThe human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle.Cyclin-dependent kinases as a therapeutic target for stroke.Adenovirus E1A directly targets the E2F/DP-1 complex.E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis.Identification and characterization of novel isoforms of human DP-1: DP-1{alpha} regulates the transcriptional activity of E2F1 as well as cell cycle progression in a dominant-negative manner.The helix-loop-helix protein ID1 localizes to centrosomes and rapidly induces abnormal centrosome numbers.E2F is required to prevent inappropriate S-phase entry of mammalian cells.Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes.
P2860
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P2860
Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1
@ast
Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1
@en
type
label
Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1
@ast
Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1
@en
prefLabel
Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1
@ast
Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1
@en
P2093
P2860
P356
P1476
Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1
@en
P2093
P2860
P304
P356
10.1128/MCB.16.7.3698
P407
P577
1996-07-01T00:00:00Z