Beta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes.
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Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patientsHuman β-cell regeneration: progress, hurdles, and controversy.Neuropeptide Y expression marks partially differentiated β cells in mice and humansBoth PAX4 and MAFA are expressed in a substantial proportion of normal human pancreatic alpha cells and deregulated in patients with type 2 diabetes.Preserving Mafa expression in diabetic islet β-cells improves glycemic control in vivoβ-Cell Deficit in Obese Type 2 Diabetes, a Minor Role of β-Cell Dedifferentiation and Degranulation.Preventing p38 MAPK-mediated MafA degradation ameliorates β-cell dysfunction under oxidative stress.Inhibition of human insulin gene transcription and MafA transcriptional activity by the dual leucine zipper kinaseA crystallin gene network in the mouse retina.Involvement of oxidative stress in suppression of insulin biosynthesis under diabetic conditions.Proper activation of MafA is required for optimal differentiation and maturation of pancreatic β-cellsMaturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice.Is β-cell aging involved in the pathogenesis of diabetes?Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo.Induction of β-cell replication by a synthetic HNF4α antagonist.Pathways governing development of stem cell-derived pancreatic β cells: lessons from embryogenesis.Glucose regulates MafA transcription factor abundance and insulin gene expression by inhibiting AMP-activated protein kinase in pancreatic β-cells.β-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells.Optical clearing of the pancreas for visualization of mature β-cells and vessels in mice.MafA is critical for maintenance of the mature beta cell phenotype in mice.
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P2860
Beta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
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2012年论文
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name
Beta cell nuclear musculoapone ...... deficient in type 2 diabetes.
@ast
Beta cell nuclear musculoapone ...... deficient in type 2 diabetes.
@en
type
label
Beta cell nuclear musculoapone ...... deficient in type 2 diabetes.
@ast
Beta cell nuclear musculoapone ...... deficient in type 2 diabetes.
@en
prefLabel
Beta cell nuclear musculoapone ...... deficient in type 2 diabetes.
@ast
Beta cell nuclear musculoapone ...... deficient in type 2 diabetes.
@en
P2093
P2860
P1433
P1476
Beta cell nuclear musculoapone ...... deficient in type 2 diabetes.
@en
P2093
A E Butler
A V Matveyenko
P C Butler
R Hernandez
R P Robertson
P2860
P2888
P304
P356
10.1007/S00125-012-2666-2
P577
2012-07-31T00:00:00Z