Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets. - Wikidata - wikimedia - TriplyDB

Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets.

Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets.

http://www.wikidata.org/entity/Q35714325

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The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings Microtubules Negatively Regulate Insulin Secretion in Pancreatic β Cells.Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding.A comparative analysis of human and mouse islet G-protein coupled receptor expression.Islet microenvironment, modulated by vascular endothelial growth factor-A signaling, promotes β cell regeneration.The MafA transcription factor becomes essential to islet β-cells soon after birth.Moving on from GWAS: functional studies on the G6PC2 gene implicated in the regulation of fasting blood glucose.The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression.Revealing transcription factors during human pancreatic β cell development.New insight on human type 1 diabetes biology: nPOD and nPOD-transplantation.Maturation of stem cell-derived beta-cells guided by the expression of urocortin 3.Both PAX4 and MAFA are expressed in a substantial proportion of normal human pancreatic alpha cells and deregulated in patients with type 2 diabetes.Human islet preparations distributed for research exhibit a variety of insulin-secretory profiles.Current concepts on the pathogenesis of type 1 diabetes--considerations for attempts to prevent and reverse the disease.Thiobenzothiazole-modified Hydrocortisones Display Anti-inflammatory Activity with Reduced Impact on Islet β-Cell Function.Tshz1 Regulates Pancreatic β-Cell Maturation.Transcriptional Regulation of the Pancreatic Islet: Implications for Islet Function.MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing β-cells to a δ-like fate and reveals a facultative proliferative capacity in aged β-cells.The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells.The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging.Beta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes.Characterization of an apparently novel β-cell line-enriched 80-88 kDa transcriptional activator of the MafA and Pdx1 genes Stress-impaired transcription factor expression and insulin secretion in transplanted human islets.Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function.Replicative capacity of β-cells and type 1 diabetes.Inactivation of specific β cell transcription factors in type 2 diabetes.Multifunctional in vivo imaging of pancreatic islets during diabetes development.The effects of Leptin and Adiponectin on Pdx1, Foxm1, and PPARγ Transcription in Rat Islets of Langerhans.Enterovirus infection of human islets of Langerhans affects β-cell function resulting in disintegrated islets, decreased glucose stimulated insulin secretion and loss of Golgi structure Pancreatic islet vasculature adapts to insulin resistance through dilation and not angiogenesis.Vascular endothelial growth factor-a and islet vascularization are necessary in developing, but not adult, pancreatic islets.A Single-Cell Transcriptome Atlas of the Human Pancreas.Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.Evidence for Loss in Identity, De-Differentiation, and Trans-Differentiation of Islet β-Cells in Type 2 Diabetes.Nutrition-/diet-induced changes in gene expression in pancreatic β-cells.Transcriptional control of mammalian pancreas organogenesis.Diabetes mellitus--advances and challenges in human β-cell proliferation.Role of transcription factors in the transdifferentiation of pancreatic islet cells.

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Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets.

http://www.wikidata.org/entity/Q35714325

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Islet-enriched gene expression ...... ion in human and mouse islets.

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Islet-enriched gene expression ...... ion in human and mouse islets.

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Islet-enriched gene expression ...... ion in human and mouse islets.

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A C Powers

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A Shostak

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C Dai

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C Thompson

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G Poffenberger

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R Stein

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Y Hang

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Z Chen

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P2860

MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.

The unique cytoarchitecture of human pancreatic islets has implications for islet cell function

Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury

The MafA transcription factor appears to be responsible for tissue-specific expression of insulin

Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells

MafB is required for islet beta cell maturation

Increased islet apoptosis in Pdx1+/- mice

Pancreatic islet GLUT2 glucose transporter mRNA and protein expression in humans with and without NIDDM.

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