Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy - Wikidata - wikimedia - TriplyDB

Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy

Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy

http://www.wikidata.org/entity/Q36570476

about

Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease Tau and tauopathies Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy Induced tauopathy in a novel 3D-culture model mediates neurodegenerative processes: a real-time study on biochips Function and regulation of tau conformations in the development and treatment of traumatic brain injury and neurodegeneration The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease Regulation of estrogen receptor α N-terminus conformation and function by peptidyl prolyl isomerase Pin1 Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin Dynamic regulation of Pin1 expression and function during zebrafish development.A common biological mechanism in cancer and Alzheimer's disease?The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules.Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function.Preclinical Alzheimer disease: brain oxidative stress, Abeta peptide and proteomics.γ-Aminobutyric acid type A (GABAA) receptor activation modulates tau phosphorylation.A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer's disease.Is tau a suitable therapeutical target in tauopathies?Oxidative stress in neurodegeneration Prolyl isomerase Pin1 promotes amyloid precursor protein (APP) turnover by inhibiting glycogen synthase kinase-3β (GSK3β) activity: novel mechanism for Pin1 to protect against Alzheimer disease.Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease.Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study Tau as a therapeutic target in neurodegenerative disease.Transcriptional signaling pathways inversely regulated in Alzheimer's disease and glioblastoma multiform.Amyloid β-peptide (1-42)-induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression.The role of tau in neurodegeneration Pin1 catalyzes conformational changes of Thr-187 in p27Kip1 and mediates its stability through a polyubiquitination process.Tau protein modifications and interactions: their role in function and dysfunction.Regulation of protein conformation by Pin1 offers novel disease mechanisms and therapeutic approaches in Alzheimer's disease Pin1 dysregulation helps to explain the inverse association between cancer and Alzheimer's disease.Effect of Pin1 or microtubule binding on dephosphorylation of FTDP-17 mutant Tau Altered learning, memory, and social behavior in type 1 taste receptor subunit 3 knock-out mice are associated with neuronal dysfunction.Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease.Prolyl isomerase Pin1 and neurotrophins: a loop that may determine the fate of cells in cancer and neurodegeneration.Cis phosphorylated tau as the earliest detectable pathogenic conformation in Alzheimer disease, offering novel diagnostic and therapeutic strategies.Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation.Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance.Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites.Analysis of in vivo turnover of tau in a mouse model of tauopathy.

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P2860

Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy

http://www.wikidata.org/entity/Q36570476

description

2008 nî lūn-bûn

@nan

2008年の論文

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2008年論文

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2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

2008年论文

@zh

2008年论文

@zh-cn

name

Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy

@ast

Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy

@en

type

label

Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy

@ast

Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy

@en

prefLabel

Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy

@ast

Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy

@en

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Journal of Clinical Investigation

P1476

Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy

@en

P2093

Anyang Sun

http://www.w3.org/2001/XMLSchema#string

Greg Finn

http://www.w3.org/2001/XMLSchema#string

Jormay Lim

http://www.w3.org/2001/XMLSchema#string

Kazuhiro Nakamura

http://www.w3.org/2001/XMLSchema#string

Kun Ping Lu

http://www.w3.org/2001/XMLSchema#string

Lucia Pastorino

http://www.w3.org/2001/XMLSchema#string

Martin Balastik

http://www.w3.org/2001/XMLSchema#string

Tae Ho Lee

http://www.w3.org/2001/XMLSchema#string

Virginia M-Y Lee

http://www.w3.org/2001/XMLSchema#string

Yih-Cherng Liou

http://www.w3.org/2001/XMLSchema#string

P2860

Function of WW domains as phosphoserine- or phosphothreonine-binding modules

The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production

Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

A human peptidyl-prolyl isomerase essential for regulation of mitosis

Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

Phosphorylation-specific prolyl isomerization: is there an underlying theme?

P304

1877-1889

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10.1172/JCI34308

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P407

P433

5

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P478

118

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2008-05-01T00:00:00Z

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18431510

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2323189

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