Mitochondrial dynamics and bioenergetic dysfunction is associated with synaptic alterations in mutant SOD1 motor neurons. - Wikidata - wikimedia - TriplyDB

Mitochondrial dynamics and bioenergetic dysfunction is associated with synaptic alterations in mutant SOD1 motor neurons.

Mitochondrial dynamics and bioenergetic dysfunction is associated with synaptic alterations in mutant SOD1 motor neurons.

http://www.wikidata.org/entity/Q36593996

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Impaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron Degeneration Ultrastructural studies of ALS mitochondria connect altered function and permeability with defects of mitophagy and mitochondriogenesis Imaging multiple sclerosis and other neurodegenerative diseases The dynamics of the mitochondrial organelle as a potential therapeutic target Extensive fusion of mitochondria in spinal cord motor neurons Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage Mitochondrial dysfunction in neurodegenerative diseases Exploring new pathways of neurodegeneration in ALS: the role of mitochondria quality control Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutants Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis.Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models.The CT20 peptide causes detachment and death of metastatic breast cancer cells by promoting mitochondrial aggregation and cytoskeletal disruption.Diisopropylfluorophosphate Impairs the Transport of Membrane-Bound Organelles in Rat Cortical Axons The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis Stem cell factor-activated bone marrow ameliorates amyotrophic lateral sclerosis by promoting protective microglial migration New Therapeutics to Modulate Mitochondrial Function in Neurodegenerative Disorders.Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis The optic nerve: a "mito-window" on mitochondrial neurodegeneration A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivo Genotype-property patient-phenotype relations suggest that proteome exhaustion can cause amyotrophic lateral sclerosis.Mitochondrial dynamics in cancer and neurodegenerative and neuroinflammatory diseases.The mitochondrial calcium regulator cyclophilin D is an essential component of oestrogen-mediated neuroprotection in amyotrophic lateral sclerosis Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death.Compartment-dependent mitochondrial alterations in experimental ALS, the effects of mitophagy and mitochondriogenesis Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy.Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling Preferential PPAR-α activation reduces neuroinflammation, and blocks neurodegeneration in vivo.Inhibitors of mitochondrial fission as a therapeutic strategy for diseases with oxidative stress and mitochondrial dysfunction.Mitochondrion-mediated cell death: dissecting yeast apoptosis for a better understanding of neurodegeneration.Selective vulnerability of motoneuron and perturbed mitochondrial calcium homeostasis in amyotrophic lateral sclerosis: implications for motoneurons specific calcium dysregulation.Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: neuroprotection by SIRT3 and PGC-1α.Expression and Distribution of Arylsulfatase B are Closely Associated with Neuron Death in SOD1 G93A Transgenic Mice.Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production.Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?Mitochondrial morphology and dynamics in hepatocytes from normal and ethanol-fed rats.Motoneuron Disease: Basic Science.Motor neuron mitochondrial dysfunction in spinal muscular atrophy Mitochondrial quality control in amyotrophic lateral sclerosis: towards a common pathway?Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases.Enhancing mitochondrial calcium buffering capacity reduces aggregation of misfolded SOD1 and motor neuron cell death without extending survival in mouse models of inherited amyotrophic lateral sclerosis

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P2860

Mitochondrial dynamics and bioenergetic dysfunction is associated with synaptic alterations in mutant SOD1 motor neurons.

http://www.wikidata.org/entity/Q36593996

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Mitochondrial dynamics and bio ...... in mutant SOD1 motor neurons.

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Mitochondrial dynamics and bio ...... in mutant SOD1 motor neurons.

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Mitochondrial dynamics and bio ...... in mutant SOD1 motor neurons.

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Mitochondrial dynamics and bio ...... in mutant SOD1 motor neurons.

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Mitochondrial dynamics and bio ...... in mutant SOD1 motor neurons.

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Mitochondrial dynamics and bio ...... in mutant SOD1 motor neurons.

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JNEUROSCI.1233-11.2012

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Journal of Neuroscience

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Mitochondrial dynamics and bio ...... in mutant SOD1 motor neurons.

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Giovanni Manfredi

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Jordi Magrané

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Mary Anne Sahawneh

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Álvaro G Estévez

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P2860

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases

Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria

Amyotrophic lateral sclerosis

Axonal membrane proteins are transported in distinct carriers: a two-color video microscopy study in cultured hippocampal neurons

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.

Transient binding of dynein controls bidirectional long-range motility of early endosomes

Engineering of a monomeric green-to-red photoactivatable fluorescent protein induced by blue light.

Opposite-polarity motors activate one another to trigger cargo transport in live cells

Monitoring secretory membrane with FM1-43 fluorescence.

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229-242

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10.1523/JNEUROSCI.1233-11.2012

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1

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Serge Przedborski

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2012-01-01T00:00:00Z

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