Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models.
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Transporting mitochondria in neuronsDysregulated axonal RNA translation in amyotrophic lateral sclerosisImpaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron DegenerationUltrastructural studies of ALS mitochondria connect altered function and permeability with defects of mitophagy and mitochondriogenesisOxidative stress and mitochondrial damage: importance in non-SOD1 ALSEnergetic and dynamic: how mitochondria meet neuronal energy demandsSpatial and temporal characteristics of normal and perturbed vesicle transportMitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degenerationExploring new pathways of neurodegeneration in ALS: the role of mitochondria quality controlThe role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosisMutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivoNew Therapeutics to Modulate Mitochondrial Function in Neurodegenerative Disorders.Abnormalities of Mitochondrial Dynamics in Neurodegenerative Diseases.Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron disease.Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis.Genetic background effects on disease onset and lifespan of the mutant dynactin p150Glued mouse model of motor neuron diseaseMiro1 deficiency in amyotrophic lateral sclerosis.ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43.Mitochondrial dynamic abnormalities in amyotrophic lateral sclerosis.Activation of ER Stress and Autophagy Induced by TDP-43 A315T as Pathogenic Mechanism and the Corresponding Histological Changes in Skin as Potential Biomarker for ALS with the MutationCompartment-dependent mitochondrial alterations in experimental ALS, the effects of mitophagy and mitochondriogenesisAbnormal mitochondrial transport and morphology as early pathological changes in human models of spinal muscular atrophy.ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function.Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanismsFunction of Armcx3 and Armc10/SVH Genes in the Regulation of Progenitor Proliferation and Neural Differentiation in the Chicken Spinal Cord.ALS-linked misfolded SOD1 species have divergent impacts on mitochondria.The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease.Neuromuscular Junction Impairment in Amyotrophic Lateral Sclerosis: Reassessing the Role of Acetylcholinesterase.Mitochondrial-Shaping Proteins in Cardiac Health and Disease - the Long and the Short of It!The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis.Mitochondrial dynamism and the pathogenesis of Amyotrophic Lateral Sclerosis.Selective vulnerability of motoneuron and perturbed mitochondrial calcium homeostasis in amyotrophic lateral sclerosis: implications for motoneurons specific calcium dysregulation.Targeting mitochondrial metal dyshomeostasis for the treatment of neurodegeneration.The interplay between metabolic homeostasis and neurodegeneration: insights into the neurometabolic nature of amyotrophic lateral sclerosis.Modeling Axonal Defects in Hereditary Spastic Paraplegia with Human Pluripotent Stem Cells.Management and therapeutic perspectives in amyotrophic lateral sclerosis.Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs.TBK1: a new player in ALS linking autophagy and neuroinflammation.Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?
P2860
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P2860
Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models.
description
2013 nî lūn-bûn
@nan
2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
name
Abnormal mitochondrial transpo ...... D1 and TDP43 ALS mouse models.
@ast
Abnormal mitochondrial transpo ...... D1 and TDP43 ALS mouse models.
@en
type
label
Abnormal mitochondrial transpo ...... D1 and TDP43 ALS mouse models.
@ast
Abnormal mitochondrial transpo ...... D1 and TDP43 ALS mouse models.
@en
prefLabel
Abnormal mitochondrial transpo ...... D1 and TDP43 ALS mouse models.
@ast
Abnormal mitochondrial transpo ...... D1 and TDP43 ALS mouse models.
@en
P2093
P2860
P356
P1476
Abnormal mitochondrial transpo ...... D1 and TDP43 ALS mouse models.
@en
P2093
Czrina Cortez
Giovanni Manfredi
Wen-Biao Gan
P2860
P304
P356
10.1093/HMG/DDT528
P577
2013-10-23T00:00:00Z