Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells.
about
The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targetsEffects of iron depletion on CALM-AF10 leukemias.The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.Targeting cancer by binding iron: Dissecting cellular signaling pathwaysThe Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling PathwaysThe metastasis suppressor, NDRG1, inhibits "stemness" of colorectal cancer via down-regulation of nuclear β-catenin and CD44.Differential targeting of the cyclin-dependent kinase inhibitor, p21CIP1/WAF1, by chelators with anti-proliferative activity in a range of tumor cell-types.Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents.Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling.The metastasis suppressor, N-myc downregulated gene 1 (NDRG1), is a prognostic biomarker for human colorectal cancer.Iron deprivation in cancer--potential therapeutic implicationsThe novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms.Quantitative molecular phenotyping of gill remodeling in a cichlid fish responding to salinity stress.Potential role of the N-MYC downstream-regulated gene family in reprogramming cancer metabolism under hypoxia.The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells.Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors.S100A16 promotes cell proliferation and metastasis via AKT and ERK cell signaling pathways in human prostate cancer.N-myc downstream-regulated gene 1 promotes oxaliplatin-triggered apoptosis in colorectal cancer cells via enhancing the ubiquitination of Bcl-2.BRAF mutations are associated with increased iron regulatory protein-2 expression in colorectal tumorigenesis.Functional non-coding polymorphism in an EPHA2 promoter PAX2 binding site modifies expression and alters the MAPK and AKT pathways.Identification of simvastatin-regulated targets associated with JNK activation in DU145 human prostate cancer cell death signaling.N-myc downstream-regulated gene 1 promotes apoptosis in colorectal cancer via up-regulating death receptor 4.The novel dithiocarbamate, DpdtC suppresses HER2-overexpressed cancer cells by up-regulating NDRG1 via inactivation of HER2-ERK 1/2 signaling.Interplay of the iron-regulated metastasis suppressor NDRG1 with epidermal growth factor receptor (EGFR) and oncogenic signaling.Lipid accumulation in human breast cancer cells injured by iron depletors.
P2860
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P2860
Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Dp44mT targets the AKT, TGF-β ...... lls and prostate cancer cells.
@ast
Dp44mT targets the AKT, TGF-β ...... lls and prostate cancer cells.
@en
type
label
Dp44mT targets the AKT, TGF-β ...... lls and prostate cancer cells.
@ast
Dp44mT targets the AKT, TGF-β ...... lls and prostate cancer cells.
@en
prefLabel
Dp44mT targets the AKT, TGF-β ...... lls and prostate cancer cells.
@ast
Dp44mT targets the AKT, TGF-β ...... lls and prostate cancer cells.
@en
P2093
P2860
P356
P1476
Dp44mT targets the AKT, TGF-β ...... ells and prostate cancer cells
@en
P2093
S J Assinder
Z Kovacevic
P2860
P2888
P304
P356
10.1038/BJC.2012.582
P407
P577
2013-01-03T00:00:00Z