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Diverse metastable structures formed by small oligomers of α-synuclein probed by force spectroscopyInhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compoundsα-Synuclein as an intrinsically disordered monomer--fact or artefact?Exploring the accessible conformations of N-terminal acetylated α-synucleinFunction and dysfunction of α-synuclein: probing conformational changes and aggregation by single molecule fluorescenceSynthetic Proteins and Peptides for the Direct Interrogation of α-Synuclein Posttranslational ModificationsDopamine and paraquat enhance α-synuclein-induced alterations in membrane conductanceFormation of toxic oligomeric alpha-synuclein species in living cellsChemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synucleinHydration dynamics as an intrinsic ruler for refining protein structure at lipid membrane interfacesClearance and phosphorylation of alpha-synuclein are inhibited in methionine sulfoxide reductase a null yeast cells.Macromolecular and Small Molecular Crowding Have Similar Effects on α-Synuclein Structure.Bacterial in-cell NMR of human α-synuclein: a disordered monomer by nature?At low concentrations, 3,4-dihydroxyphenylacetic acid (DOPAC) binds non-covalently to alpha-synuclein and prevents its fibrillationA natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicityMechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases.Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC regionModulation of alpha-synuclein expression in transgenic animals for modelling synucleinopathies--is the juice worth the squeeze?Granular assembly of alpha-synuclein leading to the accelerated amyloid fibril formation with shear stress.Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein.Early aggregation steps in alpha-synuclein as measured by FCS and FRET: evidence for a contagious conformational change.Binding of alpha-synuclein with Fe(III) and with Fe(II) and biological implications of the resultant complexes.Effect of dioxygen on copper(II) binding to alpha-synuclein.Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice.Metabolic Investigations of the Molecular Mechanisms Associated with Parkinson's DiseaseSoluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction.Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated α-synuclein.Structure activity relationship of phenolic acid inhibitors of α-synuclein fibril formation and toxicityBaicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism.Multifunctional D2/D3 agonist D-520 with high in vivo efficacy: modulator of toxicity of alpha-synuclein aggregatesHsp70 and its molecular role in nervous system diseasesProbing the micelle-bound aggregation-prone state of α-synuclein with (19)F NMR spectroscopyKinetics of amyloid aggregation: a study of the GNNQQNY prion sequence.Covalent α-synuclein dimers: chemico-physical and aggregation properties.The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding.Low-resolution structure of a vesicle disrupting α-synuclein oligomer that accumulates during fibrillation.Wildtype and A30P mutant alpha-synuclein form different fibril structures.Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease.Alpha-synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseasesFamilial Parkinson disease-associated mutations alter the site-specific microenvironment and dynamics of α-synuclein.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The aggregation and fibrillation of alpha-synuclein.
@ast
The aggregation and fibrillation of alpha-synuclein.
@en
type
label
The aggregation and fibrillation of alpha-synuclein.
@ast
The aggregation and fibrillation of alpha-synuclein.
@en
prefLabel
The aggregation and fibrillation of alpha-synuclein.
@ast
The aggregation and fibrillation of alpha-synuclein.
@en
P356
P1476
The aggregation and fibrillation of alpha-synuclein.
@en
P2093
Anthony L Fink
P304
P356
10.1021/AR050073T
P407
P577
2006-09-01T00:00:00Z