Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region
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Dopamine and paraquat enhance α-synuclein-induced alterations in membrane conductanceThe Chemistry of Neurodegeneration: Kinetic Data and Their Implications.Copper-triggered aggregation of ubiquitin.Modulation of alpha-synuclein aggregation by dopamine analogs.Residue Glu83 plays a major role in negatively regulating alpha-synuclein amyloid formationEntacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicityPathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseasesMechanisms of small-molecule binding to intrinsically disordered proteins.A relationship between the transient structure in the monomeric state and the aggregation propensities of α-synuclein and β-synucleinThe N-terminal residues 43 to 60 form the interface for dopamine mediated α-synuclein dimerisation.Phosphorylation of α-Synuclein at Y125 and S129 alters its metal binding properties: implications for understanding the role of α-Synuclein in the pathogenesis of Parkinson's Disease and related disordersOxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle.α-Synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration.Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.The function of α-synuclein.Structural, morphological, and functional diversity of amyloid oligomers.Methods of probing the interactions between small molecules and disordered proteins.How epigallocatechin gallate can inhibit α-synuclein oligomer toxicity in vitro.Atomic force microscopy based nanoassay: a new method to study α-Synuclein-dopamine bioaffinity interactions.Identification of small-molecule binding pockets in the soluble monomeric form of the Aβ42 peptide.Elucidating the aggregation number of dopamine-induced α-synuclein oligomeric assemblies.A hyperbranched dopamine-containing PEG-based polymer for the inhibition of α-synuclein fibrillationA progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats.Impact of subunit linkages in an engineered homodimeric binding protein to α-synuclein.Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration.Conformational Ensembles of α-Synuclein Derived Peptide with Different Osmolytes from Temperature Replica Exchange Sampling.Guanidine hydrochloride denaturation of dopamine-induced α-synuclein oligomers: a small-angle X-ray scattering study.Can Interactions Between α-Synuclein, Dopamine and Calcium Explain Selective Neurodegeneration in Parkinson's Disease?α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies
P2860
Q28392011-FF2BBF66-8972-47B2-BEAF-EC627542E336Q30973484-656EE58C-C7EF-4CB1-ABEB-B9DE5F377C65Q33503629-E0BD93C8-9FE5-4528-B1B1-2255FBEB4CDBQ33532593-870F7C73-F63F-49AC-A105-9307282F3ACFQ33615838-D754303C-664A-451B-AF4C-5FA988A125FFQ33832643-E84BB4BB-0A56-4050-9787-C187A7A3AAE3Q33909288-8E2910AC-561A-488F-81A0-BDDB638E081CQ34417638-85160C87-CA74-4BF8-A35A-B90C33FAB154Q34447530-396E627B-77F3-43AD-A0A2-18DB74039594Q35094912-5C89B258-2BB3-49F9-B328-E431252C134FQ36015338-6BA5F80B-1AA5-488F-81E9-6A14587C5CFFQ37509229-BE7FA082-5FF8-433B-BC5D-A3EF25FD676DQ38038123-D3ED5276-EADD-4176-81BF-170FA8A8C9CFQ38085689-46EBFDC9-D52C-442F-9358-052506BB6E1AQ38139561-2BF1D573-948C-4F0B-A061-3CC5CE7C414BQ38549882-38F8FD86-7E22-407D-B671-649179C2C768Q38669148-E1ED8E6B-667C-4AF6-82A0-0489121FB722Q38987375-01CA9882-13AC-486B-A385-BB9DE185083FQ40916287-ECE9F0DE-7B6E-4B9C-827C-C04720C0CFE9Q41015632-886181D7-3DA6-43E9-9127-472858B2C906Q41837154-3D19F230-75BC-43E4-9E5D-0F0DBB7CCF46Q42055565-E2508030-B0B2-47E9-A555-5E0F1B0B25A2Q43247253-5BB2430F-B138-4E32-92AB-2737C91923E6Q44675901-9DD57B49-8C3C-4484-8247-CE7D2AF0C0FAQ46305258-C20BD4E6-B9D8-4AFF-B5D4-DAD5B16AC4D5Q47119009-0EB843FF-07EF-4E67-85C3-3E50DE2C4C35Q50939945-8EF212AA-7A8F-4ACE-BECA-851E1AF980AFQ52624714-83180931-4DFA-43F6-BE85-498EB7DD0D04Q58765487-3DB16CC4-E634-42EA-B987-BB8E2CC54C82
P2860
Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Inhibition of alpha-synuclein ...... and with E83 in the NAC region
@ast
Inhibition of alpha-synuclein ...... and with E83 in the NAC region
@en
type
label
Inhibition of alpha-synuclein ...... and with E83 in the NAC region
@ast
Inhibition of alpha-synuclein ...... and with E83 in the NAC region
@en
altLabel
Inhibition of α-Synuclein Fibr ...... and with E83 in the NAC Region
@en
prefLabel
Inhibition of alpha-synuclein ...... and with E83 in the NAC region
@ast
Inhibition of alpha-synuclein ...... and with E83 in the NAC region
@en
P2093
P2860
P50
P921
P1433
P1476
Inhibition of alpha-synuclein ...... and with E83 in the NAC region
@en
P2093
Adrian Schmid
Adriana Munoz
Alessandra Chesi
Fernando E Herrera
Katerina E Paleologou
Stefano Gustincich
P2860
P356
10.1371/JOURNAL.PONE.0003394
P407
P577
2008-10-14T00:00:00Z