Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected] - Wikidata - wikimedia - TriplyDB

Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]

Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]

http://www.wikidata.org/entity/Q36604703

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Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice A steady state analysis indicates that negative feedback regulation of PTP1B by Akt elicits bistability in insulin-stimulated GLUT4 translocation Current understanding of metformin effect on the control of hyperglycemia in diabetes Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame Transcriptional regulation of hepatic lipogenesis Animal Models for Fibrotic Liver Diseases: What We Have, What We Need, and What Is under Development Insulin receptor signaling in normal and insulin-resistant states Phosphoinositides: Key modulators of energy metabolism Consumption of distinct dietary lipids during early pregnancy differentially modulates the expression of microRNAs in mothers and offspring CRISPR-Cas9: from Genome Editing to Cancer Research Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance PTENα, a PTEN isoform translated through alternative initiation, regulates mitochondrial function and energy metabolism Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways Role of PI3K, mTOR and Akt2 signalling in hepatic tumorigenesis via the control of PKM2 expression Negative regulators of insulin signaling revealed in a genome-wide functional screen FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity.Combined phosphatase and tensin homolog (PTEN) loss and fatty acid synthase (FAS) overexpression worsens the prognosis of Chinese patients with hepatocellular carcinoma Has natural selection in human populations produced two types of metabolic syndrome (with and without fatty liver)?Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice Deficiency of oncostatin M receptor β (OSMRβ) exacerbates high-fat diet-induced obesity and related metabolic disorders in mice.Myeloid PTEN deficiency protects livers from ischemia reperfusion injury by facilitating M2 macrophage differentiation.Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue Muscle-specific Pten deletion protects against insulin resistance and diabetes CRISPR/Cas9-mediated p53 and Pten dual mutation accelerates hepatocarcinogenesis in adult hepatitis B virus transgenic mice.PTEN mutations as a cause of constitutive insulin sensitivity and obesity.The critical role of AKT2 in hepatic steatosis induced by PTEN loss.Metabolic regulation by protein tyrosine phosphatases.Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation.Extracellular matrix dynamics in hepatocarcinogenesis: a comparative proteomics study of PDGFC transgenic and Pten null mouse models.Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training.Determining PTEN functional status by network component deduced transcription factor activities Modeling progressive non-alcoholic fatty liver disease in the laboratory mouse.Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations.CRISPR-mediated direct mutation of cancer genes in the mouse liver Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas.

P2860

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P2860

Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]

http://www.wikidata.org/entity/Q36604703

description

2004 nî lūn-bûn

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2004年の論文

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2004年論文

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2004年論文

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2004年论文

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2004年论文

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2004年论文

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name

Liver-specific deletion of neg ...... n hypersensitivity [corrected]

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Liver-specific deletion of neg ...... n hypersensitivity [corrected]

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Liver-specific deletion of neg ...... n hypersensitivity [corrected]

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Liver-specific deletion of neg ...... n hypersensitivity [corrected]

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Liver-specific deletion of neg ...... n hypersensitivity [corrected]

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PNAS.0308617100

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Liver-specific deletion of neg ...... n hypersensitivity [corrected]

@en

P2093

Andreas Stahl

http://www.w3.org/2001/XMLSchema#string

Bangyan Stiles

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Hong Wu

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Ralf Lesche

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Robert Sherwin

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Sara Bassilian

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Sherin Devaskar

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W Paul Lee

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Ying Wang

http://www.w3.org/2001/XMLSchema#string

Yoon-Jung Kim

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P2860

PTP1B regulates leptin signal transduction in vivo

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Identification of the major intestinal fatty acid transport protein

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4

Pten is essential for embryonic development and tumour suppression

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

P304

2082-2087

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scholarly article

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10.1073/PNAS.0308617100

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7

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101

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2004-02-09T00:00:00Z

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7221725

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14769918

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357055

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