The critical role of AKT2 in hepatic steatosis induced by PTEN loss. - Wikidata - wikimedia - TriplyDB

The critical role of AKT2 in hepatic steatosis induced by PTEN loss.

The critical role of AKT2 in hepatic steatosis induced by PTEN loss.

http://www.wikidata.org/entity/Q33816356

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Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways Role of PI3K, mTOR and Akt2 signalling in hepatic tumorigenesis via the control of PKM2 expression Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation.Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signaling Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models.Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes.Liver-specific inducible nitric-oxide synthase expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice.Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism Livers with constitutive mTORC1 activity resist steatosis independent of feedback suppression of Akt.PPARγ contributes to PKM2 and HK2 expression in fatty liver Mathematical Modelling of Molecular Pathways Enabling Tumour Cell Invasion and Migration.Targeting the glucose-regulated protein-78 abrogates Pten-null driven AKT activation and endometrioid tumorigenesis.Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage Hepatic proteomic analysis revealed altered metabolic pathways in insulin resistant Akt1(+/-)/Akt2(-/-) mice Saturated Fatty Acid-induced cytotoxicity in liver cells does not involve phosphatase and tensin homologue deleted on chromosome 10.Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis Systematic review: association of polycystic ovary syndrome with metabolic syndrome and non-alcoholic fatty liver disease.PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis.Molecular mechanisms of oncogene-induced inflammation and inflammation-sustained oncogene activation in gastrointestinal tumors: an under-appreciated symbiotic relationship.Wnt/β-catenin activation and macrophage induction during liver cancer development following steatosis.Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c Akt2-Dependent Phosphorylation of Radixin in Regulation of Mrp-2 Trafficking in WIF-B Cells.Maf1, A New PTEN Target Linking RNA and Lipid Metabolism.Hepatic Expression of Adenovirus 36 E4ORF1 Improves Glycemic Control and Promotes Glucose Metabolism Through AKT Activation.Unraveling the Regulation of Hepatic Metabolism by Insulin.The kielin/chordin-like protein KCP attenuates nonalcoholic fatty liver disease in mice.Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets.Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2.Constitutive Activation of AKT2 in Humans Leads to Hypoglycemia Without Fatty Liver or Metabolic Dyslipidemia.Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity.PI3K/AKT signaling regulates bioenergetics in immortalized hepatocytes.Activation of hepatic stellate cell in Pten null liver injury model.Reduced hepatic lipid content in Pten-haplodeficient mice because of enhanced AKT2/PKBβ activation in skeletal muscle.PTEN in liver diseases and cancer Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade.Adaptive basal phosphorylation of eIF2α is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes.Increase of fatty acid oxidation and VLDL assembly and secretion overexpression of PTEN in cultured hepatocytes of newborn calf.Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway.Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer.

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The critical role of AKT2 in hepatic steatosis induced by PTEN loss.

http://www.wikidata.org/entity/Q33816356

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2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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The critical role of AKT2 in hepatic steatosis induced by PTEN loss.

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The critical role of AKT2 in hepatic steatosis induced by PTEN loss.

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The critical role of AKT2 in hepatic steatosis induced by PTEN loss.

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The critical role of AKT2 in hepatic steatosis induced by PTEN loss.

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The American Journal of Pathology

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The critical role of AKT2 in hepatic steatosis induced by PTEN loss.

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Bangyan L Stiles

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Gary Kanel

http://www.w3.org/2001/XMLSchema#string

Hong Wu

http://www.w3.org/2001/XMLSchema#string

Jian Yang

http://www.w3.org/2001/XMLSchema#string

Lina He

http://www.w3.org/2001/XMLSchema#string

Morris J Birnbaum

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Ni Zeng

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Vivian Galicia

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Xiaogang Hou

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Ying Wang

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P2860

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies

Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes

PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas.

Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.

Role of Akt/protein kinase B in metabolism.

Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]

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