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Profilin-1 is a negative regulator of mammary carcinoma aggressiveness

Profilin-1 is a negative regulator of mammary carcinoma aggressiveness

http://www.wikidata.org/entity/Q36610582

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Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion Proteomic identification of Profilin1 as a corepressor of estrogen receptor alpha in MCF7 breast cancer cells Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells Molecular insights on context-specific role of profilin-1 in cell migration Profilin 1 as a target for cathepsin X activity in tumor cells Structure and functions of profilins Profilin-1 overexpression inhibits proliferation of MDA-MB-231 breast cancer cells partly through p27kip1 upregulation.Profilin-1 overexpression upregulates PTEN and suppresses AKT activation in breast cancer cells.Protein phosphatase 1 dephosphorylates profilin-1 at Ser-137 Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins A four actin-binding protein signature model for poor prognosis of patients with esophageal squamous cell carcinoma The anti-migratory effects of FKBPL and its peptide derivative, AD-01: regulation of CD44 and the cytoskeletal pathway.Profilin-1 overexpression in MDA-MB-231 breast cancer cells is associated with alterations in proteomics biomarkers of cell proliferation, survival, and motility as revealed by global proteomics analyses.Odontogenic ameloblast-associated protein (ODAM) inhibits growth and migration of human melanoma cells and elicits PTEN elevation and inactivation of PI3K/AKT signaling.Fluorescence Resonance Energy Transfer (FRET)-based Detection of Profilin-VASP Interaction.Profilin1 regulates invadopodium maturation in human breast cancer cells A high-content, multiplexed screen in human breast cancer cells identifies profilin-1 inducers with anti-migratory activities Protein profiling of human nonpigmented ciliary epithelium cell secretome: the differentiation factors characterization for retinal ganglion cell line Subcellular localization and Ser-137 phosphorylation regulate tumor-suppressive activity of profilin-1.γ-Catenin at adherens junctions: mechanism and biologic implications in hepatocellular cancer after β-catenin knockdown.Risk assessment, disease prevention and personalised treatments in breast cancer: is clinically qualified integrative approach in the horizon?Epithelial morphological reversion drives Profilin-1-induced elevation of p27(kip1) in mesenchymal triple-negative human breast cancer cells through AMP-activated protein kinase activation.PFN2, a novel marker of unfavorable prognosis, is a potential therapeutic target involved in esophageal squamous cell carcinoma.Profilin-1 versus profilin-2: two faces of the same coin?Profilin-1 downregulation has contrasting effects on early vs late steps of breast cancer metastasis Both actin and polyproline interactions of profilin-1 are required for migration, invasion and capillary morphogenesis of vascular endothelial cells.Profilin-1 overexpression restores adherens junctions in MDA-MB-231 breast cancer cells in R-cadherin-dependent manner.Differential secreted proteome approach in murine model for candidate biomarker discovery in colon cancer.Actin filaments at the leading edge of cancer cells are characterized by a high mobile fraction and turnover regulation by profilin I.A proteomics approach to identifying novel protein targets involved in erinacine A-mediated inhibition of colorectal cancer cells' aggressiveness.Controlling the cortical actin motor.The myocardin-related transcription factor MKL co-regulates the cellular levels of two profilin isoforms.Profilin potentiates chemotherapeutic agents mediated cell death via suppression of NF-κB and upregulation of p53.Mechanisms of three-dimensional growth of thyroid cells during long-term simulated microgravity.Epigenetic regulation of Smad2 and Smad3 by profilin-2 promotes lung cancer growth and metastasis.Profilin1 biology and its mutation, actin(g) in disease.Global treadmilling coordinates actin turnover and controls the size of actin networks.Poly(I:C) treatment influences the expression of calreticulin and profilin-1 in a human HNSCC cell line: a proteomic study.Loss of AF6/afadin, a marker of poor outcome in breast cancer, induces cell migration, invasiveness and tumor growth.Profilin1 is required for glial cell adhesion and radial migration of cerebellar granule neurons.

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Profilin-1 is a negative regulator of mammary carcinoma aggressiveness

http://www.wikidata.org/entity/Q36610582

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Profilin-1 is a negative regulator of mammary carcinoma aggressiveness

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Profilin-1 is a negative regulator of mammary carcinoma aggressiveness

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Profilin-1 is a negative regulator of mammary carcinoma aggressiveness

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Profilin-1 is a negative regulator of mammary carcinoma aggressiveness

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Profilin-1 is a negative regulator of mammary carcinoma aggressiveness

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British Journal of Cancer

P1476

Profilin-1 is a negative regulator of mammary carcinoma aggressiveness

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P2093

A Wells

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D Whaley

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L Zou

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M Jaramillo

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P2860

The essential role of profilin in the assembly of actin for microspike formation.

WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells

p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin.

The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins

Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri

Genomic analysis of metastasis reveals an essential role for RhoC

Actin polymerizability is influenced by profilin, a low molecular weight protein in non-muscle cells

Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach

Profilin I is essential for cell survival and cell division in early mouse development

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1023093265

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17940506

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2360229

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