Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.
about
A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptorSerine/threonine protein phosphatasesRegulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegenerationCalcineurin/Nfat signaling is required for perinatal lung maturation and functionTreatment of hippocampal neurons with cyclosporin A results in calcium overload and apoptosis which are independent on NMDA receptor activationCain, a novel physiologic protein inhibitor of calcineurinDecreased calcineurin and increased phosphothreonine-DARPP-32 in the striatum of rats behaviorally sensitized to methamphetamineThe specific FKBP38 inhibitor N-(N',N'-dimethylcarboxamidomethyl)cycloheximide has potent neuroprotective and neurotrophic properties in brain ischemia.FK506 and the role of the immunophilin FKBP-52 in nerve regeneration.Cyclophilin a binds to peroxiredoxins and activates its peroxidase activity.Neuroprotection from NMDA excitotoxic lesion by Cu/Zn superoxide dismutase gene delivery to the postnatal rat brain by a modular protein vector.Cyclophilins and their possible role in the stress response.Calcineurin links Ca2+ dysregulation with brain agingNeuroimmunophilin ligands: evaluation of their therapeutic potential for the treatment of neurological disorders.Spontaneous changes in mitochondrial membrane potential in single isolated brain mitochondriaNeuroimmunophilins: novel neuroprotective and neuroregenerative targets.Neuropsychiatric complications of liver and other solid organ transplantation.NMDA receptor and neonatal hypoxic brain injury.Potential of immunosuppressive agents in cerebral ischaemia.Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory gangliaMechanisms of dendritic spine remodeling in a rat model of traumatic brain injury.Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats.Nitric oxide: foe or friend to the injured brain?The mitochondrial permeability transition in neurologic diseaseTacrolimus in the treatment of idiopathic nephrotic syndrome.Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes.Calcineurin inhibition enhances motor neuron survival following injuryTissue engineered constructs for peripheral nerve surgery.Clinical strategies to enhance nerve regeneration in composite tissue allotransplantation.Application of topical pharmacological agents at the site of peripheral nerve injury and methods used for evaluating the success of the regenerative process.Effects of FK506 on Hippocampal CA1 Cells Following Transient Global Ischemia/Reperfusion in Wistar Rat.Glutamate-induced mitochondrial depolarisation and perturbation of calcium homeostasis in cultured rat hippocampal neurones.Calcineurin is involved in the early activation of NMDA-mediated cell death in mutant huntingtin knock-in striatal cells.Nitric oxide: role in neurotoxicity.Endogenous nitric oxide in cardiovascular disease and transplantation.Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A.Ubiquitination of neuronal nitric-oxide synthase in vitro and in vivo.Microglial apoptosis induced by chromogranin A is mediated by mitochondrial depolarisation and the permeability transition but not by cytochrome c release.Increased calcineurin expression after pilocarpine-induced status epilepticus is associated with brain focal edema and astrogliosis.Cyclosporin A and tacrolimus (FK506) suppress expression of inducible nitric oxide synthase in vitro by different mechanisms.
P2860
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P2860
Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Immunosuppressant FK506 enhanc ...... ainst glutamate neurotoxicity.
@ast
Immunosuppressant FK506 enhanc ...... ainst glutamate neurotoxicity.
@en
type
label
Immunosuppressant FK506 enhanc ...... ainst glutamate neurotoxicity.
@ast
Immunosuppressant FK506 enhanc ...... ainst glutamate neurotoxicity.
@en
prefLabel
Immunosuppressant FK506 enhanc ...... ainst glutamate neurotoxicity.
@ast
Immunosuppressant FK506 enhanc ...... ainst glutamate neurotoxicity.
@en
P2093
P2860
P921
P356
P1476
Immunosuppressant FK506 enhanc ...... ainst glutamate neurotoxicity.
@en
P2093
J L Dinerman
J P Steiner
T M Dawson
V L Dawson
P2860
P304
P356
10.1073/PNAS.90.21.9808
P407
P577
1993-11-01T00:00:00Z