about
Early implementation of QbD in biopharmaceutical development: a practical exampleDevelopment and validation of cell-based assays for the detection of neutralizing antibodies to drug products: a practical approachImproving monoclonal antibody selection and engineering using measurements of colloidal protein interactionsBoosting antibody developability through rational sequence optimization.Conformational plasticity of RNA for target recognition as revealed by the 2.15 A crystal structure of a human IgG-aptamer complexStructure of the recombinant BPTI/Kunitz-type inhibitorrShPI-1A from the marine invertebrateStichodactyla helianthusRNA plasticity and selectivity applicable to therapeutics and novel biosensor developmentUnderstanding the relationship between biotherapeutic protein stability and solid-liquid interfacial shear in constant region mutants of IgG1 and IgG4Ultrafast colorimetric determination of predominant protein structure evolution with gold nanoplasmonic particles.Predictive approach for protein aggregation: Correlation of protein surface characteristics and conformational flexibility to protein aggregation propensity.Conformational stability as a design target to control protein aggregation.Response of a concentrated monoclonal antibody formulation to high shearFluorescence single particle tracking for the characterization of submicron protein aggregates in biological fluids and complex formulations.A highly distributed Bragg stack with unique geometry provides effective camouflage for Loliginid squid eyesModel discrimination and mechanistic interpretation of kinetic data in protein aggregation studies.Glycosylation of therapeutic proteins: an effective strategy to optimize efficacyDynamic reorganization of metabolic enzymes into intracellular bodiesEvaluation of protein engineering and process optimization approaches to enhance antibody drug manufacturability.Mass spectrometric analysis of intact human monoclonal antibody aggregates fractionated by size-exclusion chromatography.Detection and characterization of subvisible aggregates of monoclonal IgG in serumManganese induces oligomerization to promote down-regulation of the intracellular trafficking receptor used by Shiga toxin.Arginine and the Hofmeister Series: the role of ion-ion interactions in protein aggregation suppression.Critical examination of the colloidal particle model of globular proteinsHollow-fiber flow field-flow fractionation with multi-angle laser scattering detection for aggregation studies of therapeutic proteins.Modeling of chemical inhibition from amyloid protein aggregation kinetics.Transmission electron microscopy as an orthogonal method to characterize protein aggregates.Direct analysis of mAb aggregates in mammalian cell culture supernatant.Functionalized micro-capillary film for the rapid at-line analysis of IgG aggregates in a cell culture bioreactor.NMR characterization of monomeric and oligomeric conformations of human calcitonin and its interaction with EGCG.Remediating agitation-induced antibody aggregation by eradicating exposed hydrophobic motifs.Stabilization of proteins in solid form.A new approach to quantification of mAb aggregates using peptide affinity probes.Silk-based stabilization of biomacromolecules.Cyclic-RGD peptides increase the adenoviral transduction of human mesenchymal stem cells.Structural analysis of a therapeutic monoclonal antibody dimer by hydroxyl radical footprinting.Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin GExtrinsic fluorescent dyes as tools for protein characterizationBurst analysis spectroscopy: a versatile single-particle approach for studying distributions of protein aggregates and fluorescent assemblies.Modulation of self-association and subsequent fibril formation in an alanine-rich helical polypeptide.Effects of glycosylation on the stability of protein pharmaceuticals.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Protein aggregation and bioprocessing.
@ast
Protein aggregation and bioprocessing.
@en
type
label
Protein aggregation and bioprocessing.
@ast
Protein aggregation and bioprocessing.
@en
prefLabel
Protein aggregation and bioprocessing.
@ast
Protein aggregation and bioprocessing.
@en
P2093
P2860
P356
P1433
P1476
Protein aggregation and bioprocessing.
@en
P2093
Eric Hilario
Fred Jacobson
Mary E M Cromwell
P2860
P2888
P304
P356
10.1208/AAPSJ080366
P407
P577
2006-09-15T00:00:00Z
P5875
P6179
1042467901