Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.
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Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting stepsHIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexesSERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by NefSeparable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signalingCo-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulationMechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes.HIV-1 Vpu targets cell surface markers CD4 and BST-2 through distinct mechanismsThe Nef protein of HIV-1 associates with rafts and primes T cells for activationThe Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrixNef-mediated clathrin-coated pit formationHuman immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase familyTargeted infection of HIV-1 Env expressing cells by HIV(CD4/CXCR4) vectors reveals a potential new rationale for HIV-1 mediated down-modulation of CD4Exosomes: Implications in HIV-1 PathogenesisHow HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4Structure, dynamics, and Hck interaction of full-length HIV-1 Nef.The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes.Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.Efficient Vpu-Mediated Tetherin Antagonism by an HIV-1 Group O Strain.Modulation of HIV-1-host interaction: role of the Vpu accessory proteinZeta chain of the T-cell receptor interacts with nef of simian immunodeficiency virus and human immunodeficiency virus type 2The proteolytic cleavage of human immunodeficiency virus type 1 Nef does not correlate with its ability to stimulate virion infectivity.A suicide gene approach using the human pro-apoptotic protein tBid inhibits HIV-1 replicationCXCR4 is down-regulated in cells infected with the CD4-independent X4 human immunodeficiency virus type 1 isolate m7NDKGenetic and functional diversity of human immunodeficiency virus type 1 subtype B Nef primary isolatesHuman immunodeficiency virus type 1 Nef-induced CD4 cell surface downregulation is inhibited by ikarugamycinIntracellular trafficking of the UL11 tegument protein of herpes simplex virus type 1.Impaired regulation of HLA-DR expression in human immunodeficiency virus-infected monocytes.Nef stimulates human immunodeficiency virus type 1 replication in primary T cells by enhancing virion-associated gp120 levels: coreceptor-dependent requirement for Nef in viral replication.Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor.Expression of simian immunodeficiency virus nef in immune cells of transgenic mice leads to a severe AIDS-like disease.Simian immunodeficiency virus Nef protein delays the progression of CD4+ T cells through G1/S phase of the cell cycle.HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2.Nef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection.Separate cellular localizations of human T-lymphotropic virus 1 (HTLV-1) Env and glucose transporter type 1 (GLUT1) are required for HTLV-1 Env-mediated fusion and infection.Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes.Misdirection of membrane trafficking by HIV-1 Vpu and Nef: Keys to viral virulence and persistence.Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor.Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesisMyxoma virus induces extensive CD4 downregulation and dissociation of p56lck in infected rabbit CD4+ T lymphocytes.
P2860
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P2860
Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Human immunodeficiency virus t ...... nd degradation of surface CD4.
@ast
Human immunodeficiency virus t ...... nd degradation of surface CD4.
@en
type
label
Human immunodeficiency virus t ...... nd degradation of surface CD4.
@ast
Human immunodeficiency virus t ...... nd degradation of surface CD4.
@en
prefLabel
Human immunodeficiency virus t ...... nd degradation of surface CD4.
@ast
Human immunodeficiency virus t ...... nd degradation of surface CD4.
@en
P2860
P1433
P1476
Human immunodeficiency virus t ...... nd degradation of surface CD4.
@en
P2093
P2860
P304
P407
P577
1994-08-01T00:00:00Z