Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.
about
Myristoyl moiety of HIV Nef is involved in regulation of the interaction with calmodulin in vivoSERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by NefMutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functionsViral entry through CXCR4 is a pathogenic factor and therapeutic target in human immunodeficiency virus type 1 diseaseThe association of Nef with a cellular serine/threonine kinase and its enhancement of infectivity are viral isolate dependentInteraction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivityImpacts of humanized mouse models on the investigation of HIV-1 infection: illuminating the roles of viral accessory proteins in vivoThe identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancementHIV-1 Nef inhibits Protease activity and its absence alters protein content of mature viral particlesIn vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis.HIV-1 infection of T cells and macrophages are differentially modulated by virion-associated Hck: a Nef-dependent phenomenonOverlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix.The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.Simian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques.Simian immunodeficiency virus and human immunodeficiency virus type 1 nef proteins show distinct patterns and mechanisms of Src kinase activation.Regions of human immunodeficiency virus type 1 nef required for function in vivoRole of the SH3-ligand domain of simian immunodeficiency virus Nef in interaction with Nef-associated kinase and simian AIDS in rhesus macaquesRefined solution structure and backbone dynamics of HIV-1 Nef.Human immunodeficiency virus type 1 Nef associates with lipid rafts to downmodulate cell surface CD4 and class I major histocompatibility complex expression and to increase viral infectivity.Conformational transition of membrane-associated terminally acylated HIV-1 Nef.Heterologous Src homology 4 domains support membrane anchoring and biological activity of HIV-1 NefV3 recombinants indicate a central role for CCR5 as a coreceptor in tissue infection by human immunodeficiency virus type 1.Rabbit cells expressing human CD4 and human CCR5 are highly permissive for human immunodeficiency virus type 1 infectionVirion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: analysis of its role in enhancement of viral infectivity.Sequence variations in human immunodeficiency virus type 1 Nef are associated with different stages of disease.Association of Nef with the human immunodeficiency virus type 1 core.Myristoylation: An Important Protein Modification in the Immune ResponseHuman immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions.Restoration of wild-type infectivity to human immunodeficiency virus type 1 strains lacking nef by intravirion reverse transcription.MLV glycosylated-Gag is an infectivity factor that rescues Nef-deficient HIV-1.Nef decreases HIV-1 sensitivity to neutralizing antibodies that target the membrane-proximal external region of TMgp41.Neutron reflectometry study of the conformation of HIV Nef bound to lipid membranesCXCR4 utilization is sufficient to trigger CD4+ T cell depletion in HIV-1-infected human lymphoid tissue.In vivo evolution of human immunodeficiency virus type 1 toward increased pathogenicity through CXCR4-mediated killing of uninfected CD4 T cells.Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes.HLA-DR+ CD38+ CD4+ T lymphocytes have elevated CCR5 expression and produce the majority of R5-tropic HIV-1 RNA in vivo.Viral determinants of HIV-1 macrophage tropism.Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef.Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein.The human immunodeficiency virus type 1 Vif protein modulates the postpenetration stability of viral nucleoprotein complexes
P2860
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P2860
Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.
description
1995 nî lūn-bûn
@nan
1995 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
name
Dissociation of the CD4 downre ...... nodeficiency virus type 1 Nef.
@ast
Dissociation of the CD4 downre ...... nodeficiency virus type 1 Nef.
@en
type
label
Dissociation of the CD4 downre ...... nodeficiency virus type 1 Nef.
@ast
Dissociation of the CD4 downre ...... nodeficiency virus type 1 Nef.
@en
prefLabel
Dissociation of the CD4 downre ...... nodeficiency virus type 1 Nef.
@ast
Dissociation of the CD4 downre ...... nodeficiency virus type 1 Nef.
@en
P2093
P2860
P1433
P1476
Dissociation of the CD4 downre ...... unodeficiency virus type 1 Nef
@en
P2093
M A Goldsmith
M D Miller
M T Warmerdam
R E Atchison
W C Greene
P2860
P304
P577
1995-07-01T00:00:00Z