Are animal models useful for studying human disc disorders/degeneration? - Wikidata - wikimedia - TriplyDB

Are animal models useful for studying human disc disorders/degeneration?

Are animal models useful for studying human disc disorders/degeneration?

http://www.wikidata.org/entity/Q36627417

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Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: implications for disk degeneration and chordoma formation Stem cells sources for intervertebral disc regeneration A Review of Animal Models of Intervertebral Disc Degeneration: Pathophysiology, Regeneration, and Translation to the Clinic Diversity of intervertebral disc cells: phenotype and function Challenges and strategies in the repair of ruptured annulus fibrosus Percutaneous disc decompression with nucleoplasty-volumetry of the nucleus pulposus using ultrahigh-field MRI Animal models for disc degeneration-an update.Thoracic spine morphology of a pseudo-biped animal model (kangaroo) and comparisons with human and quadruped animals.Long-Term Creep Behavior of the Intervertebral Disk: Comparison between Bioreactor Data and Numerical Results.Loss and re-adaptation of lumbar intervertebral disc water signal intensity after prolonged bedrest.Quantitative MRI water content mapping of porcine intervertebral disc during uniaxial compression.Bovine explant model of degeneration of the intervertebral disc.Running exercise strengthens the intervertebral disc.A novel finite element model of the ovine lumbar intervertebral disc with anisotropic hyperelastic material properties.The effect of repetitive flexion and extension fatigue loading on the young porcine lumbar spine, a feasibility study of MRI and histological analyses.Effects of annulus defects and implantation of poly(lactic-co-glycolic acid) (PLGA)/fibrin gel scaffolds on nerves ingrowth in a rabbit model of annular injury disc degeneration A Histopathological Scheme for the Quantitative Scoring of Intervertebral Disc Degeneration and the Therapeutic Utility of Adult Mesenchymal Stem Cells for Intervertebral Disc Regeneration.The aging mouse partially models the aging human spine: lumbar and coccygeal disc height, composition, mechanical properties, and Wnt signaling in young and old mice.Histological features of endplates of the mammalian spine: from mice to men Lentiviral shRNA silencing of CHOP inhibits apoptosis induced by cyclic stretch in rat annular cells and attenuates disc degeneration in the rats.Differential expression level of cytokeratin 8 in cells of the bovine nucleus pulposus complicates the search for specific intervertebral disc cell markers.Vertebral bodies or discs: which contributes more to human-like lumbar lordosis?Comparison of vertebral and intervertebral disc lesions in aging humans and rhesus monkeys Characterization of the age-dependent intervertebral disc changes in rabbit by correlation between MRI, histology and gene expression.Sensitivity of notochordal disc cells to mechanical loading: an experimental animal study Analysis of the load on the knee joint and vertebral column with changes in squatting depth and weight load.Simulated-physiological loading conditions preserve biological and mechanical properties of caprine lumbar intervertebral discs in ex vivo culture Radiographic incidence of spinal osteopathologies in captive rhesus monkeys (Macaca mulatta).The dog as an animal model for DISH?Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc.Chronic neck pain: making the connection between capsular ligament laxity and cervical instability.Evaluation of unilateral cage-instrumented fixation for lumbar spine.Localized Intervertebral Disc Injury Leads to Organ Level Changes in Structure, Cellularity, and Biosynthesis Disc volume reduction with percutaneous nucleoplasty in an animal model.In vivo and in vitro analysis of rat lumbar spine mechanics SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells.Dynamic and static overloading induce early degenerative processes in caprine lumbar intervertebral discs.Preliminary investigations on intradiscal pressures during daily activities: an in vivo study using the merino sheep.CT-guided injection technique into intervertebral discs in the ovine lumbar spine.Region specific response of intervertebral disc cells to complex dynamic loading: an organ culture study using a dynamic torsion-compression bioreactor.

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P2860

Are animal models useful for studying human disc disorders/degeneration?

http://www.wikidata.org/entity/Q36627417

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European Spine Journal

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James Melrose

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Keita Ito

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P2860

Collagen II is essential for the removal of the notochord and the formation of intervertebral discs

Progressive ankylosis, a new skeletal mutation in the mouse

A fibronectin fragment stimulates intervertebral disc degeneration in vivo.

ISSLS prize winner: A novel approach to determine trunk muscle forces during flexion and extension: a comparison of data from an in vitro experiment and in vivo measurements.

Experimental disc degeneration due to endplate injury.

Disc degeneration in the rabbit: a biochemical and radiological comparison between four disc injury models.

Maternal age influences risk for HLA-B27 associated ankylosing enthesopathy in transgenic mice.

Inflammatory disease in HLA-B27 transgenic rats.

1990 Volvo Award in experimental studies. Anulus tears and intervertebral disc degeneration. An experimental study using an animal model.

Length variation in the keratan sulfate domain of mammalian aggrecan.

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