Evolution of the oncogenic potential of v-rel: rel-induced expression of immunoregulatory receptors correlates with tumor development and in vitro transformation
about
A novel interferon regulatory factor (IRF), IRF-10, has a unique role in immune defense and is induced by the v-Rel oncoprotein.Mutational analysis of the v-Rel dimerization interface reveals a critical role for v-Rel homodimers in transformationInterferon regulatory factor 4 contributes to transformation of v-Rel-expressing fibroblastsMechanism of telomerase activation by v-Rel and its contribution to transformation.The relocalization of v-Rel from the nucleus to the cytoplasm coincides with induction of expression of Ikba and nfkb1 and stabilization of I kappa B-alpha.Mutations in the DNA-binding and dimerization domains of v-Rel are responsible for altered kappa B DNA-binding complexes in transformed cellsRepression of B-cell linker (BLNK) and B-cell adaptor for phosphoinositide 3-kinase (BCAP) is important for lymphocyte transformation by rel proteins.v-rel Induces ectopic expression of an adhesion molecule, DM-GRASP, during B-lymphoma developmentInteraction of the v-Rel oncoprotein with NF-kappaB and IkappaB proteins: heterodimers of a transformation-defective v-Rel mutant and NF-2 are functional in vitro and in vivo.ch-IAP1, a member of the inhibitor-of-apoptosis protein family, is a mediator of the antiapoptotic activity of the v-Rel oncoprotein.In vivo evolution of c-rel oncogenic potential.CAPERalpha is a novel Rel-TAD-interacting factor that inhibits lymphocyte transformation by the potent Rel/NF-kappaB oncoprotein v-Rel.Regulation of telomerase activity by interferon regulatory factors 4 and 8 in immune cells.A mutant v-rel with increased ability to transform B lymphocytes.Alternatively spliced telomerase reverse transcriptase variants lacking telomerase activity stimulate cell proliferation.PEST-dependent cytoplasmic retention of v-Rel by I(kappa)B-alpha: evidence that I(kappa)B-alpha regulates cellular localization of c-Rel and v-Rel by distinct mechanisms.
P2860
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P2860
Evolution of the oncogenic potential of v-rel: rel-induced expression of immunoregulatory receptors correlates with tumor development and in vitro transformation
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Evolution of the oncogenic pot ...... nt and in vitro transformation
@ast
Evolution of the oncogenic pot ...... nt and in vitro transformation
@en
type
label
Evolution of the oncogenic pot ...... nt and in vitro transformation
@ast
Evolution of the oncogenic pot ...... nt and in vitro transformation
@en
prefLabel
Evolution of the oncogenic pot ...... nt and in vitro transformation
@ast
Evolution of the oncogenic pot ...... nt and in vitro transformation
@en
P2093
P2860
P1433
P1476
Evolution of the oncogenic pot ...... nt and in vitro transformation
@en
P2093
E H Humphries
R Hrdlicková
P2860
P304
P407
P577
1994-04-01T00:00:00Z