Small molecule natural products in the discovery of therapeutic agents: the synthesis connection.
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Capturing Biological Activity in Natural Product Fragments by Chemical SynthesisConcise total synthesis of (±)-actinophyllic acid.Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analogDesign, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivitySynthesis of Diverse Heterocyclic Scaffolds via Tandem Additions to Imine Derivatives and Ring-Forming Reactions.Synthesis of azaphilone-based chemical librariesNitroso Diels-Alder (NDA) reaction as an efficient tool for the functionalization of diene-containing natural productsNatural products: a continuing source of novel drug leadsTotal syntheses and biological reassessment of lactimidomycin, isomigrastatin and congener glutarimide antibiotics.Capturing the essence of organic synthesis: from bioactive natural products to designed molecules in today's medicine.Nickel-catalyzed cross-couplings involving carbon-oxygen bondsEfficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 InhibitionMultifaceted cytoprotection by synthetic polyacetylenes inspired by the ginseng-derived natural product, panaxytriol.Total synthesis and biological evaluation of tyroscherin.An approach to the site-selective deoxygenation of hydroxy groups based on catalytic phosphoramidite transferDiverted Total Synthesis of Promysalin Analogs Demonstrates That an Iron-Binding Motif Is Responsible for Its Narrow-Spectrum Antibacterial ActivityOne-Step Synthetic Access to Isosteric and Potent Anticancer Nitrogen Heterocycles with the Benzo[c]phenanthridine Scaffold.Twelve-membered macrolactones: privileged scaffolds for the development of new therapeutics.A novel natural product inspired scaffold with robust neurotrophic, neurogenic and neuroprotective actionSynthetic studies toward (+)-cortistatin AStrategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates.Revealing nature's synthetic potential through the study of ribosomal natural product biosynthesis.Therapeutic effect against human xenograft tumors in nude mice by the third generation microtubule stabilizing epothilones.A viable synthesis of N-methyl cysteine.New chemistry with old functional groups: on the reaction of isonitriles with carboxylic acids--a route to various amide types.Pattern recognition analysis in complex molecule synthesis and the preparation of iso-Diels-Alder motifsEvaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.A concise synthesis of the cortistatin core.A novel α,β-unsaturated nitrone-aryne [3+2] cycloaddition and its application in the synthesis of the cortistatin core.(3R, 9R, 10R)-Panaxytriol: A molecular-based nutraceutical with possible application to cancer prevention and treatment.Synthesis of pluraflavin A "aglycone"Total synthesis of spirotenuipesines A and B.Exploiting hidden symmetry in natural products: total syntheses of amphidinolides C and F.Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer-dimer interface.Ribosomally synthesized and post-translationally modified peptide natural products: new insights into the role of leader and core peptides during biosynthesis.A unified strategy for enantioselective total synthesis of cladiellin and briarellin diterpenes: total synthesis of briarellins E and F and the putative structure of alcyonin and revision of its structure assignment.Asymmetric total synthesis of alkaloids 223A and 6-epi-223ADefining the mode of action of tetramic acid antibacterials derived from Pseudomonas aeruginosa quorum sensing signals.Terpenyl-purines from the sea.Probing the biology of natural products: molecular editing by diverted total synthesis.
P2860
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P2860
Small molecule natural products in the discovery of therapeutic agents: the synthesis connection.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Small molecule natural product ...... nts: the synthesis connection.
@ast
Small molecule natural product ...... nts: the synthesis connection.
@en
type
label
Small molecule natural product ...... nts: the synthesis connection.
@ast
Small molecule natural product ...... nts: the synthesis connection.
@en
prefLabel
Small molecule natural product ...... nts: the synthesis connection.
@ast
Small molecule natural product ...... nts: the synthesis connection.
@en
P356
P1476
Small molecule natural product ...... nts: the synthesis connection.
@en
P2093
Rebecca M Wilson
Samuel J Danishefsky
P304
P356
10.1021/JO0610053
P407
P577
2006-10-01T00:00:00Z