Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity - Wikidata - wikimedia - TriplyDB

Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity

Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity

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Contemporary Strategies for the Synthesis of Tetrahydropyran Derivatives: Application to Total Synthesis of Neopeltolide, a Marine Macrolide Natural Product Capturing Biological Activity in Natural Product Fragments by Chemical Synthesis The Novel PKCθ from Benchtop to Clinic Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro Bioengineered vaults: self-assembling protein shell-lipophilic core nanoparticles for drug delivery.Total synthesis of bryostatin 9 Synthesis of seco-B-ring bryostatin analogue WN-1 via C-C bond-forming hydrogenation: critical contribution of the B-ring in determining bryostatin-like and phorbol 12-myristate 13-acetate-like properties.Concise synthesis and biological assessment of (+)-neopeltolide and a 16-member stereoisomer library of 8,9-dehydroneopeltolide: identification of pharmacophoric elements.Improved protein kinase C affinity through final step diversification of a simplified salicylate-derived bryostatin analog scaffold.Lead Diversification through a Prins-Driven Macrocyclization Strategy: Application to C13-Diversified Bryostatin Analogues.Dual role of novel ingenol derivatives from Euphorbia tirucalli in HIV replication: inhibition of de novo infection and activation of viral LTR.Toward a biorelevant structure of protein kinase C bound modulators: design, synthesis, and evaluation of labeled bryostatin analogues for analysis with rotational echo double resonance NMR spectroscopy "Picolog," a synthetically-available bryostatin analog, inhibits growth of MYC-induced lymphoma in vivo.Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action.Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers Simplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death.Toward the Ideal Synthesis and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis.Protein kinase C, an elusive therapeutic target?Alkyl Cinnamates Induce Protein Kinase C Translocation and Anticancer Activity against Breast Cancer Cells through Induction of the Mitochondrial Pathway of Apoptosis.Microbial natural products: molecular blueprints for antitumor drugs.Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin.Design and synthesis of analogues of natural products.Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities.Protein Kinase C Activation as a Potential Therapeutic Strategy in Alzheimer's Disease: Is there a Role for Embryonic Lethal Abnormal Vision-like Proteins?Multifunctional roles of PKCδ: Opportunities for targeted therapy in human disease Histone deacetylase inhibitors (HDACis) that release the positive transcription elongation factor b (P-TEFb) from its inhibitory complex also activate HIV transcription.Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.Protein kinase C and cardiac dysfunction: a review.Function Oriented Synthesis: Preparation and Initial Biological Evaluation of New A-Ring-Modified Bryologs.Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-like Biology.Bryostatin analog: improving on Nature's design.Insights into the Dual Activity of a Bifunctional Dehydratase-Cyclase Domain.Syntheses of C17-C27 fragments of 20-deoxybryostatins for assembly using Julia and metathesis reactions.Total Synthesis of Bryostatin 8 Using an Organosilane-Based Strategy.REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment.Total synthesis of 7-des-O-pivaloyl-7-O-benzylbryostatin 10.Synthetic approaches to the C11-C27 fragments of bryostatins.The evolution of a stereoselective synthesis of the C1-C16 fragment of bryostatins.Furan-Site Bromination and Transformations of Fraxinellone as Insecticidal Agents Against Mythimna separata Walker.Bioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry

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P2860

Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity

http://www.wikidata.org/entity/Q33849709

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2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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Design, synthesis, and evaluat ...... PKC translocation selectivity

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Design, synthesis, and evaluat ...... PKC translocation selectivity

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Design, synthesis, and evaluat ...... PKC translocation selectivity

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Design, synthesis, and evaluat ...... PKC translocation selectivity

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Design, synthesis, and evaluat ...... PKC translocation selectivity

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Design, synthesis, and evaluat ...... PKC translocation selectivity

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Design, synthesis, and evaluat ...... PKC translocation selectivity

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Adam J Schrier

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Brian A DeChristopher

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Brian A Loy

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Jeremy L Baryza

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Paul A Wender

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Stacey E Brenner

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Vishal A Verma

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P2860

Molecular modeling, total synthesis, and biological evaluations of C9-deoxy bryostatin 1

Postischemic PKC activation rescues retrograde and anterograde long-term memory

Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches

Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV

Target-oriented and diversity-oriented organic synthesis in drug discovery

Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner

A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC

Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals

Natural products as sources of new drugs over the last 25 years

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