SPAK differentially mediates vasopressin effects on sodium cotransporters.
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New insights into sodium transport regulation in the distal nephron: Role of G-protein coupled receptorsRegulation of nephron water and electrolyte transport by adenylyl cyclasesRegulation of NKCC2 activity by inhibitory SPAK isoforms: KS-SPAK is a more potent inhibitor than SPAK2Sympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension.Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrierRegulation of with-no-lysine kinase signaling by Kelch-like proteins.Distal convoluted tubuleGeneration of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing.STE20/SPS1-related proline/alanine-rich kinase (SPAK) is critical for sodium reabsorption in isolated, perfused thick ascending limb.Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3SPAK-mediated NCC regulation in response to low-K+ dietPerspective of future drugs targeting sterile 20/SPS1-related proline/alanine-rich kinase for blood pressure control.A Systems Level Analysis of Vasopressin-mediated Signaling Networks in Kidney Distal Convoluted Tubule Cells.Kelch-Like Protein 2 Mediates Angiotensin II-With No Lysine 3 Signaling in the Regulation of Vascular Tonus.Alternatively spliced proline-rich cassettes link WNK1 to aldosterone actionCalcineurin and Sorting-Related Receptor with A-Type Repeats Interact to Regulate the Renal Na⁺-K⁺-2Cl⁻ CotransporterWNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron.Annexin A2 mediates apical trafficking of renal Na⁺-K⁺-2Cl⁻ cotransporter.WNK signalling pathways in blood pressure regulationClaudin expression in the rat endolymphatic duct and sac - first insights into regulation of the paracellular barrier by vasopressin.Neurohormonal interactions on the renal oxygen delivery and consumption in haemorrhagic shock-induced acute kidney injury.Electroneutral absorption of NaCl by the aldosterone-sensitive distal nephron: implication for normal electrolytes homeostasis and blood pressure regulation.Vasopressin regulation of sodium transport in the distal nephron and collecting duct.Kelch-like 3/Cullin 3 ubiquitin ligase complex and WNK signaling in salt-sensitive hypertension and electrolyte disorder.Mini-review: regulation of the renal NaCl cotransporter by hormones.Physiological role of SLC12 family members in the kidney.Regulation of renal Na-(K)-Cl cotransporters by vasopressin.Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport.Demonstration of the functional impact of vasopressin signaling in the thick ascending limb by a targeted transgenic rat approach.SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule.Alternative splice variant of the thiazide-sensitive NaCl cotransporter: a novel player in renal salt handling.Modulation of NCC activity by low and high K(+) intake: insights into the signaling pathways involved.Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4.Direct and Indirect Mineralocorticoid Effects Determine Distal Salt Transport.Ovarian hormones and prolactin increase renal NaCl cotransporter phosphorylation.K+-induced natriuresis is preserved during Na+ depletion and accompanied by inhibition of the Na+-Cl- cotransporter.Caveolin 1 Promotes Renal Water and Salt Reabsorption.Calcineurin inhibitor cyclosporine A activates renal Na-K-Cl cotransporters via local and systemic mechanisms.H,K-ATPase type 2 contributes to salt-sensitive hypertension induced by K(+) restriction.Novel mechanisms of Na+ retention in obesity: phosphorylation of NKCC2 and regulation of SPAK/OSR1 by AMPK.
P2860
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P2860
SPAK differentially mediates vasopressin effects on sodium cotransporters.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
SPAK differentially mediates vasopressin effects on sodium cotransporters.
@ast
SPAK differentially mediates vasopressin effects on sodium cotransporters.
@en
type
label
SPAK differentially mediates vasopressin effects on sodium cotransporters.
@ast
SPAK differentially mediates vasopressin effects on sodium cotransporters.
@en
prefLabel
SPAK differentially mediates vasopressin effects on sodium cotransporters.
@ast
SPAK differentially mediates vasopressin effects on sodium cotransporters.
@en
P2093
P2860
P50
P356
P1476
SPAK differentially mediates vasopressin effects on sodium cotransporters
@en
P2093
Alexander Paliege
Aljona Borschewski
Christin Dathe
Eric Delpire
James A McCormick
Kerim Mutig
Nina Himmerkus
Sebastian Bachmann
Shinichi Uchida
Sylvie Demaretz
P2860
P304
P356
10.1681/ASN.2012040404
P577
2013-02-07T00:00:00Z