Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system.
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Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3Novel crosstalk to BMP signalling: cGMP-dependent kinase I modulates BMP receptor and Smad activityGlucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activityNodal morphogensRegulation of TGF-β signal transduction by mono- and deubiquitylation of SmadsThe GSK-3 family as therapeutic target for myocardial diseasesModeling protein association mechanisms and kineticsA Smad action turnover switch operated by WW domain readers of a phosphoserine codeMediator MED15 modulates transforming growth factor beta (TGFβ)/Smad signaling and breast cancer cell metastasisCoupled reversible and irreversible bistable switches underlying TGFβ-induced epithelial to mesenchymal transitionCharacterizing changes in the rate of protein-protein dissociation upon interface mutation using hotspot energy and organizationModel-based analysis for qualitative data: an application in Drosophila germline stem cell regulationNuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell DifferentiationProfiling Subcellular Protein Phosphatase Responses to Coxsackievirus B3 Infection of Cardiomyocytes.Tracing the molecular basis of transcriptional dynamics in noisy data by using an experiment-based mathematical model.Sensing relative signal in the Tgf-β/Smad pathwayAn integrative modeling framework reveals plasticity of TGF-β signaling.Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathwaysThe self-limiting dynamics of TGF-β signaling in silico and in vitro, with negative feedback through PPM1A upregulation.Dynamics of TGF-β/Smad signalingPlasticity of TGF-β signalingKinetic rate constant prediction supports the conformational selection mechanism of protein binding.Inferring Biological Mechanisms by Data-Based Mathematical Modelling: Compartment-Specific Gene Activation during Sporulation in Bacillus subtilis as a Test Case.Studying Smad2 intranuclear diffusion dynamics by mathematical modelling of FRAP experiments.Dynamic regulation of Tgf-B signaling by Tif1γ: a computational approach.Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-β signalling pathway.Efficient calculation of steady state probability distribution for stochastic biochemical reaction network.Epigenetic control of vascular smooth muscle cells in Marfan and non-Marfan thoracic aortic aneurysms.Cooperative assembly of Co-Smad4 MH1 with R-Smad1/3 MH1 on DNA: a molecular dynamics simulation studyUbiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling.Computational modeling of mammalian signaling networks.Characterization of negative feedback network motifs in the TGF-β signaling pathwayQuantitative analysis of transient and sustained transforming growth factor-β signaling dynamics.Modeling TGF-β in early stages of cancer tissue dynamics.The role of the microenvironment in tumor growth and invasionResponse to Nodal morphogen gradient is determined by the kinetics of target gene induction.Quantitative analysis of receptor tyrosine kinase-effector coupling at functionally relevant stimulus levels.Plasmin triggers a switch-like decrease in thrombospondin-dependent activation of TGF-β1.Sorting nexin 9 differentiates ligand-activated Smad3 from Smad2 for nuclear import and transforming growth factor β signaling.Bioactive food components, inflammatory targets, and cancer prevention.
P2860
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P2860
Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Mathematical modeling identifi ...... ic signal-interpreting system.
@ast
Mathematical modeling identifi ...... ic signal-interpreting system.
@en
type
label
Mathematical modeling identifi ...... ic signal-interpreting system.
@ast
Mathematical modeling identifi ...... ic signal-interpreting system.
@en
prefLabel
Mathematical modeling identifi ...... ic signal-interpreting system.
@ast
Mathematical modeling identifi ...... ic signal-interpreting system.
@en
P2860
P50
P356
P1476
Mathematical modeling identifi ...... ic signal-interpreting system.
@en
P2093
Alexander L Tournier
P2860
P304
P356
10.1073/PNAS.0710134105
P407
P577
2008-04-28T00:00:00Z