Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents
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Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention.Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo.Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3).Multi-targeted therapy of cancer by niclosamide: A new application for an old drug.Evolution in medicinal chemistry of ursolic acid derivatives as anticancer agentsSTAT3 modulation to enhance motor neuron differentiation in human neural stem cells.Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposureStructure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists.Development of Novel 1,2,3,4-Tetrahydroquinoline Scaffolds as Potent NF-κB Inhibitors and Cytotoxic AgentsPreclinical evaluation of a nanoformulated antihelminthic, niclosamide, in ovarian cancer.Effect of niclosamide on basal-like breast cancers.Suppression of the Growth and Invasion of Human Head and Neck Squamous Cell Carcinomas via Regulating STAT3 Signaling and the miR-21/β-catenin Axis with HJC0152.Novel carbazole inhibits phospho-STAT3 through induction of protein-tyrosine phosphatase PTPN6.Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth.mTOR Mediates IL-23 Induction of Neutrophil IL-17 and IL-22 Production.Novel 2-Carbonylbenzo[b]thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway.Fabrication of Niclosamide loaded solid lipid nanoparticles: in vitro characterization and comparative in vivo evaluation.The role of STAT3 in leading the crosstalk between human cancers and the immune system.GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3.A new synthetic derivative of cryptotanshinone KYZ3 as STAT3 inhibitor for triple-negative breast cancer therapy
P2860
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P2860
Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Discovery of O-Alkylamino Teth ...... Bioavailable Anticancer Agents
@ast
Discovery of O-Alkylamino Teth ...... Bioavailable Anticancer Agents
@en
type
label
Discovery of O-Alkylamino Teth ...... Bioavailable Anticancer Agents
@ast
Discovery of O-Alkylamino Teth ...... Bioavailable Anticancer Agents
@en
prefLabel
Discovery of O-Alkylamino Teth ...... Bioavailable Anticancer Agents
@ast
Discovery of O-Alkylamino Teth ...... Bioavailable Anticancer Agents
@en
P2093
P2860
P356
P1476
Discovery of O-Alkylamino Teth ...... Bioavailable Anticancer Agents
@en
P2093
Chunyong Ding
Haijun Chen
Huiling Liu
Kristin Terry
Qiang Shen
Yusong Zhang
Zhengduo Yang
P2860
P304
P356
10.1021/ML3003082
P577
2013-01-15T00:00:00Z