Ryanodine receptors and ventricular arrhythmias: emerging trends in mutations, mechanisms and therapies.
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Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmiasA network-oriented perspective on cardiac calcium signalingCrystal structure of type I ryanodine receptor amino-terminal -trefoil domain reveals a disease-associated mutation"hot spot"loopPatient Specific Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Development and Screening In Catecholaminergic Polymorphic Ventricular TachycardiaThe RYR2-encoded ryanodine receptor/calcium release channel in patients diagnosed previously with either catecholaminergic polymorphic ventricular tachycardia or genotype negative, exercise-induced long QT syndrome: a comprehensive open reading framCardiac ryanodine receptors control heart rate and rhythmicity in adult miceCardiomyocyte ATP production, metabolic flexibility, and survival require calcium flux through cardiac ryanodine receptors in vivoEarly cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel.An X-linked channelopathy with cardiomegaly due to a CLIC2 mutation enhancing ryanodine receptor channel activity.Heterogeneity of ryanodine receptor dysfunction in a mouse model of catecholaminergic polymorphic ventricular tachycardiaStructural insights into the human RyR2 N-terminal region involved in cardiac arrhythmiasGenetic testing of inherited arrhythmias.Dysregulated sarcoplasmic reticulum calcium release: potential pharmacological target in cardiac disease.Ryanodine receptor channelopathies.Potential role of Hsp25 in calcium-modulated cardiomyocytes.Spontaneous Ca2+ sparks and Ca2+ homeostasis in a minimal model of permeabilized ventricular myocytes.Superresolution modeling of calcium release in the heartLocalization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor.Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling moleculesGeneration and characterization of a mouse model harboring the exon-3 deletion in the cardiac ryanodine receptor.The H29D Mutation Does Not Enhance Cytosolic Ca2+ Activation of the Cardiac Ryanodine ReceptorCalcium/calmodulin-dependent protein kinase II (CaMKII) inhibition ameliorates arrhythmias elicited by junctin ablation under stress conditionsChain-reaction Ca(2+) signaling in the heart.Abnormal termination of Ca2+ release is a common defect of RyR2 mutations associated with cardiomyopathiesDantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia.Loss of luminal Ca2+ activation in the cardiac ryanodine receptor is associated with ventricular fibrillation and sudden deathThe contribution of hydrophobic residues in the pore-forming region of the ryanodine receptor channel to block by large tetraalkylammonium cations and Shaker B inactivation peptides.S100A1 DNA-based Inotropic Therapy Protects Against Proarrhythmogenic Ryanodine Receptor 2 Dysfunction.Luminal Mg2+, a key factor controlling RYR2-mediated Ca2+ release: cytoplasmic and luminal regulation modeled in a tetrameric channelAbnormal Ca(2+) homeostasis, atrial arrhythmogenesis, and sinus node dysfunction in murine hearts modeling RyR2 modificationTricyclic antidepressant amitriptyline alters sarcoplasmic reticulum calcium handling in ventricular myocytesPhysiological consequences of the P2328S mutation in the ryanodine receptor (RyR2) gene in genetically modified murine hearts.Ryanodine receptor-mediated arrhythmias and sudden cardiac death.Targeting calcium handling in arrhythmias.Localization of PKA phosphorylation site, Ser(2030), in the three-dimensional structure of cardiac ryanodine receptor.Ryanodine receptor mutations in arrhythmia: The continuing mystery of channel dysfunction.The genetic and clinical features of cardiac channelopathies.Treatment of asymptomatic catecholaminergic polymorphic ventricular tachycardia.Inherited calcium channelopathies in the pathophysiology of arrhythmias.Posttranslational modifications of cardiac ryanodine receptors: Ca(2+) signaling and EC-coupling.
P2860
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P2860
Ryanodine receptors and ventricular arrhythmias: emerging trends in mutations, mechanisms and therapies.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Ryanodine receptors and ventri ...... ons, mechanisms and therapies.
@ast
Ryanodine receptors and ventri ...... ons, mechanisms and therapies.
@en
type
label
Ryanodine receptors and ventri ...... ons, mechanisms and therapies.
@ast
Ryanodine receptors and ventri ...... ons, mechanisms and therapies.
@en
prefLabel
Ryanodine receptors and ventri ...... ons, mechanisms and therapies.
@ast
Ryanodine receptors and ventri ...... ons, mechanisms and therapies.
@en
P2093
P1476
Ryanodine receptors and ventri ...... ons, mechanisms and therapies.
@en
P2093
Christopher H George
Debra L Fry
F Anthony Lai
Hala Jundi
N Lowri Thomas
P356
10.1016/J.YJMCC.2006.08.115
P577
2006-11-01T00:00:00Z