Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel.
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Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunctionTargeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure'Ryanopathy': causes and manifestations of RyR2 dysfunction in heart failureS100A1 and calmodulin regulation of ryanodine receptor in striated muscleFRET detection of calmodulin binding to the cardiac RyR2 calcium release channelNovel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks.Intracellular translocation of calmodulin and Ca2+/calmodulin-dependent protein kinase II during the development of hypertrophy in neonatal cardiomyocytes.Inhibition of CaMKII does not attenuate cardiac hypertrophy in mice with dysfunctional ryanodine receptorThe ryanodine receptor in cardiac physiology and disease.Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure.Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failureModulation of sarcoplasmic reticulum Ca2+ release in skeletal muscle expressing ryanodine receptor impaired in regulation by calmodulin and S100A1.Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling moleculesAberrant interaction of calmodulin with the ryanodine receptor develops hypertrophy in the neonatal cardiomyocyteAMP-activated protein kinase regulates E3 ligases in rodent heart.Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity.mTOR signaling in mice with dysfunctional cardiac ryanodine receptor ion channel.PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban.Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts.Up-regulation of sarcoplasmic reticulum Ca(2+) uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2.Cardiac hypertrophy associated with impaired regulation of cardiac ryanodine receptor by calmodulin and S100A1.The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+ Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine ReceptorRyanodine receptor studies using genetically engineered mice.Emerging roles for native Orai Ca2+ channels in cardiovascular diseaseEmerging roles of junctophilin-2 in the heart and implications for cardiac diseases.The emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression of heart failure and the antiarrhythmic action of dantrolene.Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure.Activation of IP3 receptors requires an endogenous 1-8-14 calmodulin-binding motif.Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy?Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model.Long noncoding RNA Chast promotes cardiac remodeling.CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift.IL-6/STAT3 signaling in mice with dysfunctional type-2 ryanodine receptor.Dyad content is reduced in cardiac myocytes of mice with impaired calmodulin regulation of RyR2.Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-mediated Ca2+ Release.Arrhythmogenic calmodulin mutations disrupt intracellular cardiomyocyte Ca2+ regulation by distinct mechanisms.Alpha-kinase anchoring protein alphaKAP interacts with SERCA2A to spatially position Ca2+/calmodulin-dependent protein kinase II and modulate phospholamban phosphorylation.Cardiac calcium signalling pathologies associated with defective calmodulin regulation of type 2 ryanodine receptor.Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.Role of calmodulin and myosin light chain kinase in the activation of carbachol-activated cationic current in murine ileal myocytes.
P2860
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P2860
Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel.
description
2007 nî lūn-bûn
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2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Early cardiac hypertrophy in m ...... diac muscle Ca release channel
@nl
Early cardiac hypertrophy in m ...... iac muscle Ca release channel.
@ast
Early cardiac hypertrophy in m ...... iac muscle Ca release channel.
@en
type
label
Early cardiac hypertrophy in m ...... diac muscle Ca release channel
@nl
Early cardiac hypertrophy in m ...... iac muscle Ca release channel.
@ast
Early cardiac hypertrophy in m ...... iac muscle Ca release channel.
@en
prefLabel
Early cardiac hypertrophy in m ...... diac muscle Ca release channel
@nl
Early cardiac hypertrophy in m ...... iac muscle Ca release channel.
@ast
Early cardiac hypertrophy in m ...... iac muscle Ca release channel.
@en
P2093
P2860
P356
P1476
Early cardiac hypertrophy in m ...... iac muscle Ca release channel.
@en
P2093
Gerhard Meissner
Naohiro Yamaguchi
Nobuyuki Takahashi
P2860
P304
P356
10.1172/JCI29515
P407
P577
2007-04-12T00:00:00Z