Antisense phosphorothioate oligodeoxynucleotides targeted to the vpr gene inhibit human immunodeficiency virus type 1 replication in primary human macrophages
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Polymerase-endonuclease amplification reaction (PEAR) for large-scale enzymatic production of antisense oligonucleotidesHuman immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) interacts with Lys-tRNA synthetase: implications for priming of HIV-1 reverse transcription.Viral protein R regulates nuclear import of the HIV-1 pre-integration complexHIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycleHuman immunodeficiency virus type 1 Vpr protein binds to the uracil DNA glycosylase DNA repair enzymeHuman immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin BThe human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycleThe glucocorticoid receptor type II complex is a target of the HIV-1 vpr gene productActivation of the ATR pathway by human immunodeficiency virus type 1 Vpr involves its direct binding to chromatin in vivoRegulation of HIV-1 transcription in cells of the monocyte-macrophage lineage.Interaction with the p6 domain of the gag precursor mediates incorporation into virions of Vpr and Vpx proteins from primate lentivirusesMaintenance of an intact human immunodeficiency virus type 1 vpr gene following mother-to-infant transmissionCell cycle-regulated transcription by the human immunodeficiency virus type 1 Tat transactivator.Activation of transcription factors NF-kappaB and NF-IL-6 by human immunodeficiency virus type 1 protein R (Vpr) induces interleukin-8 expressionThe functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase.Molecular pathways in virus-induced cytokine production.Mutagenesis of the putative alpha-helical domain of the Vpr protein of human immunodeficiency virus type 1: effect on stability and virion incorporation.Depletion of Wee-1 kinase is necessary for both human immunodeficiency virus type 1 Vpr- and gamma irradiation-induced apoptosis.A domain of human immunodeficiency virus type 1 Vpr containing repeated H(S/F)RIG amino acid motifs causes cell growth arrest and structural defects.HIV-1 Vpr induces interferon-stimulated genes in human monocyte-derived macrophages.Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.Extracellular Vpr protein increases cellular permissiveness to human immunodeficiency virus replication and reactivates virus from latency.V3-independent determinants of macrophage tropism in a primary human immunodeficiency virus type 1 isolate.The p6gag domain of human immunodeficiency virus type 1 is sufficient for the incorporation of Vpr into heterologous viral particlesFate of the human immunodeficiency virus type 1 provirus in infected cells: a role for vprA leucine triplet repeat sequence (LXX)4 in p6gag is important for Vpr incorporation into human immunodeficiency virus type 1 particlesMutagenic analysis of human immunodeficiency virus type 1 Vpr: role of a predicted N-terminal alpha-helical structure in Vpr nuclear localization and virion incorporation.A conserved LXXLF sequence is the major determinant in p6gag required for the incorporation of human immunodeficiency virus type 1 Vpr.Vpr-induced cell cycle arrest is conserved among primate lentiviruses.Sequences regulating tropism of human immunodeficiency virus type 1 for brain capillary endothelial cells map to a unique region on the viral genome.Mapping of independent V3 envelope determinants of human immunodeficiency virus type 1 macrophage tropism and syncytium formation in lymphocytes.Serum Vpr regulates productive infection and latency of human immunodeficiency virus type 1Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr.Expression of the c-myc proto-oncogene is essential for HIV-1 infection in activated T cells.The HIV-1 vpr protein acts as a negative regulator of apoptosis in a human lymphoblastoid T cell line: possible implications for the pathogenesis of AIDSHuman immunodeficiency virus type 1 Vpr is a positive regulator of viral transcription and infectivity in primary human macrophagesRequirement of the Pr55gag precursor for incorporation of the Vpr product into human immunodeficiency virus type 1 viral particles.A transcriptional regulatory element is associated with a nuclease-hypersensitive site in the pol gene of human immunodeficiency virus type 1.Inhibition of NF-κB activity by HIV-1 Vpr is dependent on Vpr binding protein.HIV relies on neddylation for ubiquitin ligase-mediated functions
P2860
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P2860
Antisense phosphorothioate oligodeoxynucleotides targeted to the vpr gene inhibit human immunodeficiency virus type 1 replication in primary human macrophages
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Antisense phosphorothioate oli ...... n in primary human macrophages
@ast
Antisense phosphorothioate oli ...... n in primary human macrophages
@en
type
label
Antisense phosphorothioate oli ...... n in primary human macrophages
@ast
Antisense phosphorothioate oli ...... n in primary human macrophages
@en
prefLabel
Antisense phosphorothioate oli ...... n in primary human macrophages
@ast
Antisense phosphorothioate oli ...... n in primary human macrophages
@en
P2093
P2860
P1433
P1476
Antisense phosphorothioate oli ...... n in primary human macrophages
@en
P2093
P2860
P304
P407
P50
P577
1993-07-01T00:00:00Z