The E1A products of oncogenic adenovirus serotype 12 include amino-terminally modified forms able to bind the retinoblastoma protein but not p300
about
Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding proteinE1A promotes association between p300 and pRB in multimeric complexes required for normal biological activityA novel function of adenovirus E1A is required to overcome growth arrest by the CDK2 inhibitor p27(Kip1).The N terminus of adenovirus type 12 E1A inhibits major histocompatibility complex class I expression by preventing phosphorylation of NF-kappaB p65 Ser276 through direct binding.Mutational analysis of the conserved region 2 site of adenovirus E1A and its effect on binding to the retinoblastoma gene product: use of the "double-tagging" assayThree unrelated viral transforming proteins (vIRF, EBNA2, and E1A) induce the MYC oncogene through the interferon-responsive PRF element by using different transcription coadaptors.Viral oncoproteins target the DNA methyltransferases.Suppression of mutations in two Saccharomyces cerevisiae genes by the adenovirus E1A protein.Reduced phosphorylation of p50 is responsible for diminished NF-kappaB binding to the major histocompatibility complex class I enhancer in adenovirus type 12-transformed cells.Oct-1 potentiates CREB-driven cyclin D1 promoter activation via a phospho-CREB- and CREB binding protein-independent mechanism.E1A 12S and 13S of the transformation-defective adenovirus type 12 strain CS-1 inactivate proteins of the RB family, permitting transactivation of the E2F-dependent promoter.A multiprotein complex consisting of the cellular coactivator p300, AP-1/ATF, as well as NF-kappaB is responsible for the activation of the mouse major histocompatibility class I (H-2K(b)) enhancer A
P2860
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P2860
The E1A products of oncogenic adenovirus serotype 12 include amino-terminally modified forms able to bind the retinoblastoma protein but not p300
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name
The E1A products of oncogenic ...... oblastoma protein but not p300
@ast
The E1A products of oncogenic ...... oblastoma protein but not p300
@en
type
label
The E1A products of oncogenic ...... oblastoma protein but not p300
@ast
The E1A products of oncogenic ...... oblastoma protein but not p300
@en
prefLabel
The E1A products of oncogenic ...... oblastoma protein but not p300
@ast
The E1A products of oncogenic ...... oblastoma protein but not p300
@en
P2093
P2860
P1433
P1476
The E1A products of oncogenic ...... oblastoma protein but not p300
@en
P2093
P2860
P304
P407
P577
1993-08-01T00:00:00Z