Structural organization, expression, and functional characterization of the murine cytomegalovirus immediate-early gene 3
about
Cloning and mutagenesis of a herpesvirus genome as an infectious bacterial artificial chromosomeDetermination and analysis of the complete nucleotide sequence of human herpesvirusMurine cytomegalovirus stimulates cellular thymidylate synthase gene expression in quiescent cells and requires the enzyme for replicationIdentification of a mouse cytomegalovirus gene selectively targeting CD86 expression on antigen-presenting cells.Focal transcriptional activity of murine cytomegalovirus during latency in the lungs.Biphasic recruitment of transcriptional repressors to the murine cytomegalovirus major immediate-early promoter during the course of infection in vivoHighly protective in vivo function of cytomegalovirus IE1 epitope-specific memory CD8 T cells purified by T-cell receptor-based cell sortingPreemptive CD8 T-cell immunotherapy of acute cytomegalovirus infection prevents lethal disease, limits the burden of latent viral genomes, and reduces the risk of virus recurrence.Enhancer requirement for murine cytomegalovirus growth and genetic complementation by the human cytomegalovirus enhancer.Elimination of ie1 significantly attenuates murine cytomegalovirus virulence but does not alter replicative capacity in cell cultureEnrichment of immediate-early 1 (m123/pp89) peptide-specific CD8 T cells in a pulmonary CD62L(lo) memory-effector cell pool during latent murine cytomegalovirus infection of the lungsIn vivo replication of recombinant murine cytomegalovirus driven by the paralogous major immediate-early promoter-enhancer of human cytomegalovirusPatchwork pattern of transcriptional reactivation in the lungs indicates sequential checkpoints in the transition from murine cytomegalovirus latency to recurrenceThe major immediate-early gene ie3 of mouse cytomegalovirus is essential for viral growth.Rat cytomegalovirus major immediate-early enhancer switching results in altered growth characteristics.Random, asynchronous, and asymmetric transcriptional activity of enhancer-flanking major immediate-early genes ie1/3 and ie2 during murine cytomegalovirus latency in the lungs.Enhancerless cytomegalovirus is capable of establishing a low-level maintenance infection in severely immunodeficient host tissues but fails in exponential growth.Processing and presentation of murine cytomegalovirus pORFm164-derived peptide in fibroblasts in the face of all viral immunosubversive early gene functionsAblation of the regulatory IE1 protein of murine cytomegalovirus alters in vivo pro-inflammatory TNF-alpha production during acute infectionAn essential role of the enhancer for murine cytomegalovirus in vivo growth and pathogenesis.CD8 T cells control cytomegalovirus latency by epitope-specific sensing of transcriptional reactivationThe effect of murine cytomegalovirus IE-3 specific shRNA is dependent on intragenic target site due to multiple transcription initiation sitesReversible inhibition of murine cytomegalovirus replication by gamma interferon (IFN-γ) in primary macrophages involves a primed type I IFN-signaling subnetwork for full establishment of an immediate-early antiviral state.Murine cytomegalovirus with a deletion of genes spanning HindIII-J and -I displays altered cell and tissue tropismLatency versus persistence or intermittent recurrences: evidence for a latent state of murine cytomegalovirus in the lungsMurine cytomegalovirus infection of mouse macrophages stimulates early expression of suppressor of cytokine signaling (SOCS)1 and SOCS3.A short cis-acting motif in the M112-113 promoter region is essential for IE3 to activate M112-113 gene expression and is important for murine cytomegalovirus replicationNucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functionsStructure and function of the murine cytomegalovirus sgg1 gene: a determinant of viral growth in salivary gland acinar cells.Characterization of the major locus of immediate-early genes of rat cytomegalovirus.Identification and mapping of dimerization and DNA-binding domains in the C terminus of the IE2 regulatory protein of human cytomegalovirus.Laboratory strains of murine cytomegalovirus are genetically similar to but phenotypically distinct from wild strains of virus.Transplant-induced reactivation of murine cytomegalovirus immediate early gene expression is associated with recruitment of NF-κB and AP-1 to the major immediate early promoter.Cell cycle-independent expression of immediate-early gene 3 results in G1 and G2 arrest in murine cytomegalovirus-infected cells.Transactivation of cellular genes involved in nucleotide metabolism by the regulatory IE1 protein of murine cytomegalovirus is not critical for viral replicative fitness in quiescent cells and host tissuesEstablishment of murine cytomegalovirus latency in vivo is associated with changes in histone modifications and recruitment of transcriptional repressors to the major immediate-early promoter.Epigenetic control of cytomegalovirus latency and reactivation.The mouse cytomegalovirus immediate-early 1 gene is not required for establishment of latency or for reactivation in the lungs.Liver sinusoidal endothelial cells are a site of murine cytomegalovirus latency and reactivationRole for tumor necrosis factor alpha in murine cytomegalovirus transcriptional reactivation in latently infected lungs.
P2860
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P2860
Structural organization, expression, and functional characterization of the murine cytomegalovirus immediate-early gene 3
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Structural organization, expre ...... lovirus immediate-early gene 3
@ast
Structural organization, expre ...... lovirus immediate-early gene 3
@en
type
label
Structural organization, expre ...... lovirus immediate-early gene 3
@ast
Structural organization, expre ...... lovirus immediate-early gene 3
@en
prefLabel
Structural organization, expre ...... lovirus immediate-early gene 3
@ast
Structural organization, expre ...... lovirus immediate-early gene 3
@en
P2093
P2860
P1433
P1476
Structural organization, expre ...... lovirus immediate-early gene 3
@en
P2093
P2860
P407
P577
1992-01-01T00:00:00Z