Functional evidence for ligand-dependent dissociation of thyroid hormone and retinoic acid receptors from an inhibitory cellular factor
about
NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptorsPSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptorsDomain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation.A nuclear hormone receptor-associated protein that inhibits transactivation by the thyroid hormone and retinoic acid receptorsBoth corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3Interactions of thyroid hormone receptor with the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and the HIV-1 Tat transactivatorUnique forms of human and mouse nuclear receptor corepressor SMRTRetinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiationNew retinoid X receptor subtypes in zebra fish (Danio rerio) differentially modulate transcription and do not bind 9-cis retinoic acidHeterodimeric interaction between retinoid X receptor alpha and orphan nuclear receptor OR1 reveals dimerization-induced activation as a novel mechanism of nuclear receptor activationSpecific mutations in the ligand binding domain selectively abolish the silencing function of human thyroid hormone receptor beta.Transcriptional repression by the SMRT-mSin3 corepressor: multiple interactions, multiple mechanisms, and a potential role for TFIIB.Transcriptional silencing is defined by isoform- and heterodimer-specific interactions between nuclear hormone receptors and corepressorsDeterminants of chromatin disruption and transcriptional regulation instigated by the thyroid hormone receptor: hormone-regulated chromatin disruption is not sufficient for transcriptional activationNuclear receptor engineering based on novel structure activity relationships revealed by farnesyl pyrophosphate.Transcriptional repression by Rev-erbA alpha is dependent on the signature motif and helix 5 in the ligand binding domain: silencing does not involve an interaction with N-CoR.Transcriptional repression by the orphan steroid receptor RVR/Rev-erb beta is dependent on the signature motif and helix 5 in the E region: functional evidence for a biological role of RVR in myogenesis.Nuclear receptor-dependent transcription with chromatin. Is it all about enzymes?The steroid receptor coactivator, GRIP-1, is necessary for MEF-2C-dependent gene expression and skeletal muscle differentiation.Direct modulation of simian virus 40 late gene expression by thyroid hormone and its receptor.The in vivo role of nuclear receptor corepressors in thyroid hormone action.Identification of thyroid hormone response elements in the human fatty acid synthase promoterGenetic dissection of thyroid hormone receptor beta: identification of mutations that separate hormone binding and transcriptional activation.A 10-amino-acid sequence in the N-terminal A/B domain of thyroid hormone receptor alpha is essential for transcriptional activation and interaction with the general transcription factor TFIIB.The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeatActivation and repression by nuclear hormone receptors: hormone modulates an equilibrium between active and repressive states.Nuclear receptor steroidogenic factor 1 directs embryonic stem cells toward the steroidogenic lineageA conformational switch in nuclear hormone receptors is involved in coupling hormone binding to corepressor releaseConstitutive activation of gene expression by thyroid hormone receptor results from reversal of p53-mediated repression.Transcriptional anti-repression. Thyroid hormone receptor beta-2 recruits SMRT corepressor but interferes with subsequent assembly of a functional corepressor complex.Retinoid isomers differ in the ability to induce release of SMRT corepressor from retinoic acid receptor-alphaThe nuclear receptors COUP-TF: a long-lasting experience in forebrain assembly.Ligand modulates the interaction of thyroid hormone receptor beta with the basal transcription machinery.Transactivation of the human apolipoprotein CII promoter by orphan and ligand-dependent nuclear receptors. The regulatory element CIIC is a thyroid hormone response element.A nuclear hormone receptor corepressor mediates transcriptional silencing by receptors with distinct repression domains.Molecular mechanisms of COUP-TF-mediated transcriptional repression: evidence for transrepression and active repression.The actions of thyroid hormone signaling in the nucleus.tau4/tau c/AF-2 of the thyroid hormone receptor relieves silencing of the retinoic acid receptor silencer core independent of both tau4 activation function and full dissociation of corepressors.Transcriptional silencing by unliganded thyroid hormone receptor beta requires a soluble corepressor that interacts with the ligand-binding domain of the receptor.Functional evidence for retinoid X receptor (RXR) as a nonsilent partner in the thyroid hormone receptor/RXR heterodimer.
P2860
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P2860
Functional evidence for ligand-dependent dissociation of thyroid hormone and retinoic acid receptors from an inhibitory cellular factor
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Functional evidence for ligand ...... an inhibitory cellular factor
@ast
Functional evidence for ligand ...... an inhibitory cellular factor
@en
type
label
Functional evidence for ligand ...... an inhibitory cellular factor
@ast
Functional evidence for ligand ...... an inhibitory cellular factor
@en
prefLabel
Functional evidence for ligand ...... an inhibitory cellular factor
@ast
Functional evidence for ligand ...... an inhibitory cellular factor
@en
P2093
P2860
P356
P1476
Functional evidence for ligand ...... an inhibitory cellular factor
@en
P2093
H H Samuels
J Casanova
M Au-Fliegner
N Koudinova
S Selmi-Ruby
V Desai-Yajnik
P2860
P304
P356
10.1128/MCB.14.9.5756
P407
P577
1994-09-01T00:00:00Z