Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants.
about
OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6Formation of a large, complex domain of histone hyperacetylation at human 14q32.1 requires the serpin locus control regionDissociation of the hepatic phenotype from HNF4 and HNF1alpha expressionDifferential regulation of gene activity and chromatin structure within the human serpin gene cluster at 14q32.1 in macrophage microcell hybrids.The HNF-4/HNF-1alpha transactivation cascade regulates gene activity and chromatin structure of the human serine protease inhibitor gene cluster at 14q32.1.Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cellsDefective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4alpha (HNF4alpha ). HNF4alpha regulates ornithine transcarbamylase in vivo.An enhancer element 6 kb upstream of the mouse HNF4alpha1 promoter is activated by glucocorticoids and liver-enriched transcription factors.Hepatocyte nuclear factor-4 prevents silencing of hepatocyte nuclear factor-1 expression in hepatoma x fibroblast cell hybrids.TFIIB-directed transcriptional activation by the orphan nuclear receptor hepatocyte nuclear factor 4.Liver-enriched transcription factors uncoupled from expression of hepatic functions in hepatoma cell lines.Underexpressed coactivators PGC1alpha and SRC1 impair hepatocyte nuclear factor 4 alpha function and promote dedifferentiation in human hepatoma cells.Selective loss of the hepatic phenotype due to the absence of a transcriptional activation pathway.
P2860
Q22008694-B1D24081-3CAD-4C2A-AD2C-DF2AFE0C1A2EQ24810303-969C67F3-87BC-4CAB-B4FB-B6EFECF1C41BQ28271954-9DCB0ABB-7185-481F-A4D8-6BE5820BAC00Q33620545-44633EA2-CFC1-4249-A877-03FB18DAE44CQ35620187-51E24D28-4779-45EE-975A-1DB94192C7D2Q36567504-E4DAA0B7-7C35-4CE7-B9B9-9525A4D6CCF7Q38289521-D25A59F8-ACF5-455D-89A9-5FEE408E31F3Q39097884-1FDCDFFB-46F1-4F4D-B60B-89DD9BF883BCQ39720279-C7FBDD46-E298-4288-9820-3C3C94B58FAEQ40018632-5D496474-8419-4141-BFA1-B29B8726BC48Q40023719-6DF13AFC-49FB-4C4C-88FE-86F920953D8EQ40246865-E3B1B73F-FE65-4653-A7BE-209E5BEC206DQ41111265-A00CF576-78B0-4CEB-BC32-93C70D898F3F
P2860
Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants.
@ast
Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants.
@en
type
label
Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants.
@ast
Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants.
@en
prefLabel
Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants.
@ast
Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants.
@en
P2860
P356
P1476
Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants.
@en
P2093
R E Fournier
P2860
P304
P356
10.1128/MCB.14.11.7086
P407
P577
1994-11-01T00:00:00Z