Defective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4alpha (HNF4alpha ). HNF4alpha regulates ornithine transcarbamylase in vivo.
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Cited2, a coactivator of HNF4alpha, is essential for liver developmentHNF4 alpha orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cellsCrosstalk of HNF4α with extracellular and intracellular signaling pathways in the regulation of hepatic metabolism of drugs and lipidsIn vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping.Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liverHepatic gene expression profiling reveals key pathways involved in leptin-mediated weight loss in ob/ob mice.Hepatocyte nuclear factor 4{alpha} regulates rifampicin-mediated induction of CYP2C genes in primary cultures of human hepatocytesAlterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alphaRegulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.Med25 is required for RNA polymerase II recruitment to specific promoters, thus regulating xenobiotic and lipid metabolism in human liver.The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cellsA metabolic stress-inducible miR-34a-HNF4α pathway regulates lipid and lipoprotein metabolismSuppression of hepatocyte proliferation by hepatocyte nuclear factor 4α in adult mice.HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoterHepatocyte Nuclear Factor 4α Controls Iron Metabolism and Regulates Transferrin Receptor 2 in Mouse Liver.Hepatocyte-specific deletion of hepatocyte nuclear factor-4α in adult mice results in increased hepatocyte proliferation.Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9.Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel diseaseMorphogenetic competence of HNF4 alpha-deficient mouse hepatic cells.Regulation of hepatic microRNA expression by hepatocyte nuclear factor 4 alpha.Hepatocyte nuclear factor 4α transactivates the mitochondrial alanine aminotransferase gene in the kidney of Sparus aurata.Underexpressed coactivators PGC1alpha and SRC1 impair hepatocyte nuclear factor 4 alpha function and promote dedifferentiation in human hepatoma cells.Pathophysiology and fate of hepatocytes in a mouse model of mitochondrial hepatopathies.Role of HNF4alpha in the superinduction of the IL-1beta-activated iNOS gene by oxidative stressCCAAT/enhancer-binding protein alpha (C/EBPalpha) and hepatocyte nuclear factor 4alpha (HNF4alpha) synergistically cooperate with constitutive androstane receptor to transactivate the human cytochrome P450 2B6 (CYP2B6) gene: application to the develC/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism.AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability.Hepatocyte nuclear factor 4alpha is a central regulator of bile acid conjugation.Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and age-dependent hepatosteatosis.Expression of the alpha7 isoform of hepatocyte nuclear factor (HNF) 4 is activated by HNF6/OC-2 and HNF1 and repressed by HNF4alpha1 in the liver.An HNF4α-microRNA-194/192 signaling axis maintains hepatic cell function.Down-regulation of hepatocyte nuclear factor-4α and defective zonation in livers expressing mutant Z α1-antitrypsin.The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter.Sequential Exposure to Cytokines Reflecting Embryogenesis: The Key for in vitro Differentiation of Adult Bone Marrow Stem Cells into Functional Hepatocyte-like CellsREVERBa couples the circadian clock to hepatic glucocorticoid action
P2860
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P2860
Defective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4alpha (HNF4alpha ). HNF4alpha regulates ornithine transcarbamylase in vivo.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Defective ureagenesis in mice ...... hine transcarbamylase in vivo.
@en
type
label
Defective ureagenesis in mice ...... hine transcarbamylase in vivo.
@en
prefLabel
Defective ureagenesis in mice ...... hine transcarbamylase in vivo.
@en
P2093
P2860
P356
P1476
Defective ureagenesis in mice ...... hine transcarbamylase in vivo.
@en
P2093
Frank J Gonzalez
Graham P Hayhurst
Junko Inoue
Masataka Mori
Yusuke Inoue
P2860
P304
25257-25265
P356
10.1074/JBC.M203126200
P407
P577
2002-05-06T00:00:00Z