Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter
about
Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits.Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorderAge-dependent effects of A53T alpha-synuclein on behavior and dopaminergic functionTrace amine-associated receptor 1: A promising target for the treatment of psychostimulant addictionKinetics of the dopamine transporter in Drosophila larvaSustained N-methyl-d-aspartate receptor hypofunction remodels the dopamine system and impairs phasic signaling.Subcortical dopaminergic deficits in a DISC1 mutant model: a study in direct reference to human molecular brain imaging.Enduring increases in anxiety-like behavior and rapid nucleus accumbens dopamine signaling in socially isolated rats.Dopamine transporters in striatum correlate with deactivation in the default mode network during visuospatial attentionForward genetic analysis to identify determinants of dopamine signaling in Caenorhabditis elegans using swimming-induced paralysisMisassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits.Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression.Hyperdopaminergic tone erodes prefrontal long-term potential via a D2 receptor-operated protein phosphatase gateSensitized nucleus accumbens dopamine terminal responses to methylphenidate and dopamine transporter releasers after intermittent-access self-administration.Simultaneous decoupled detection of dopamine and oxygen using pyrolyzed carbon microarrays and fast-scan cyclic voltammetryProgressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein.Transgenic overexpression of the presynaptic choline transporter elevates acetylcholine levels and augments motor endurance.The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and D-amphetamine.Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmissionIntracellular methamphetamine prevents the dopamine-induced enhancement of neuronal firingMSI-1436 reduces acute food intake without affecting dopamine transporter activity.An easy and versatile 2-step protocol for targeted modification and subcloning of DNA from bacterial artificial chromosomes using non-commercial plasmids.Amphetamine potency varies with dopamine uptake rate across striatal subregions.Adaptations of presynaptic dopamine terminals induced by psychostimulant self-administration.Neurotransplantation of stem cells genetically modified to express human dopamine transporter reduces alcohol consumption.Amphetamine and methamphetamine differentially affect dopamine transporters in vitro and in vivo.Differential influence of dopamine transport rate on the potencies of cocaine, amphetamine, and methylphenidateN-terminal tagging of the dopamine transporter impairs protein expression and trafficking in vivo.mTORC2/rictor signaling disrupts dopamine-dependent behaviors via defects in striatal dopamine neurotransmission.Monoamine transporters: vulnerable and vital doorkeepers.Increased dopamine transporter function as a mechanism for dopamine hypoactivity in the adult infralimbic medial prefrontal cortex following adolescent social stressOptimizing the Temporal Resolution of Fast-Scan Cyclic Voltammetry.Methylphenidate and cocaine self-administration produce distinct dopamine terminal alterations.Single cell measurement of dopamine release with simultaneous voltage-clamp and amperometry.Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter.Dopamine transporter mutant animals: a translational perspective.Amphetamine activates an amine-gated chloride channel to generate behavioral effects in Caenorhabditis elegans.Transgenic mouse models for ADHD.Sesamin modulates tyrosine hydroxylase, superoxide dismutase, catalase, inducible NO synthase and interleukin-6 expression in dopaminergic cells under MPP+-induced oxidative stressTonic autoinhibition contributes to the heterogeneity of evoked dopamine release in the rat striatum.
P2860
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P2860
Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Increased amphetamine-induced ...... ssing the dopamine transporter
@ast
Increased amphetamine-induced ...... ssing the dopamine transporter
@en
type
label
Increased amphetamine-induced ...... ssing the dopamine transporter
@ast
Increased amphetamine-induced ...... ssing the dopamine transporter
@en
prefLabel
Increased amphetamine-induced ...... ssing the dopamine transporter
@ast
Increased amphetamine-induced ...... ssing the dopamine transporter
@en
P2093
P2860
P356
P1476
Increased amphetamine-induced ...... ssing the dopamine transporter
@en
P2093
Ali Salahpour
Amy J Ramsey
Brian Kile
Ericka Holmstrand
Ivan O Medvedev
Karen Murphy
Marc G Caron
Peter J Nicholls
R Mark Wightman
P2860
P304
P356
10.1073/PNAS.0707646105
P407
P577
2008-03-17T00:00:00Z