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Most efficient cocaine hydrolase designed by virtual screening of transition statesPhage display--a powerful technique for immunotherapy: 2. Vaccine deliveryStructural analysis of thermostabilizing mutations of cocaine esteraseRational Design, Preparation, and Characterization of a Therapeutic Enzyme Mutant with Improved Stability and Function for Cocaine DetoxificationDesign of high-activity mutants of human butyrylcholinesterase against (-)-cocaine: structural and energetic factors affecting the catalytic efficiency.Virus-based chemical and biological sensing.Structure-and-mechanism-based design and discovery of therapeutics for cocaine overdose and addiction.Rational design of an enzyme mutant for anti-cocaine therapeuticsBacteriophage Bundles with Pre-Aligned Ca Initiate the Oriented Nucleation and Growth of Hydroxylapatite.Computational redesign of human butyrylcholinesterase for anticocaine medication.Toward cocaine esterase therapeuticsDesign, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine.Nanofibrous bio-inorganic hybrid structures formed through self-assembly and oriented mineralization of genetically engineered phage nanofibers.Kinetic characterization of human butyrylcholinesterase mutants for the hydrolysis of cocaethylene.Kinetic characterization of high-activity mutants of human butyrylcholinesterase for the cocaine metabolite norcocaine.Bio-inspired supramolecular self-assembly towards soft nanomaterials.Infecting the brain to stop addiction?Cell permeable cocaine esterases constructed by chemical conjugation and genetic recombination.Bacteriophage penetration in vertebrates.Bacteriophage-mediated protein delivery into the central nervous system and its application in immunopharmacotherapy.Recent advances for the treatment of cocaine abuse: central nervous system immunopharmacotherapy.Virus-based photo-responsive nanowires formed by linking site-directed mutagenesis and chemical reactionFood and gut microbes for thoughtsFree-energy perturbation simulation on transition states and redesign of butyrylcholinesterase.Immunopharmacotherapy: vaccination strategies as a treatment for drug abuse and dependence.Anti-drug vaccines to treat substance abuse.Amino-acid mutations to extend the biological half-life of a therapeutically valuable mutant of human butyrylcholinesterase.A bacteriophages journey through the human body.Neuromodulation interventions for addictive disorders: challenges, promise, and roadmap for future research.Dopamine transporter inhibition is required for cocaine-induced stereotypy.Free energy perturbation simulation on transition states and high-activity mutants of human butyrylcholinesterase for (-)-cocaine hydrolysis.Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine.Computational design of a human butyrylcholinesterase mutant for accelerating cocaine hydrolysis based on the transition-state simulation.Kinetic characterization of a cocaine hydrolase engineered from mouse butyrylcholinesterase.Catalytic activities of a cocaine hydrolase engineered from human butyrylcholinesterase against (+)- and (-)-cocaine.Free energy perturbation (FEP) simulation on the transition states of cocaine hydrolysis catalyzed by human butyrylcholinesterase and its mutants.A model of glycosylated human butyrylcholinesterase.Substrate selectivity of high-activity mutants of human butyrylcholinesterase.Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers.Drug delivery vectors based on filamentous bacteriophages and phage-mimetic nanoparticles.
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Treating cocaine addiction with viruses
@ast
Treating cocaine addiction with viruses
@en
type
label
Treating cocaine addiction with viruses
@ast
Treating cocaine addiction with viruses
@en
prefLabel
Treating cocaine addiction with viruses
@ast
Treating cocaine addiction with viruses
@en
P2093
P2860
P356
P1476
Treating cocaine addiction with viruses
@en
P2093
George F Koob
Gunnar F Kaufmann
Jenny M Mee
Kim D Janda
M Rocio A Carrera
Michael M Meijler
P2860
P304
10416-10421
P356
10.1073/PNAS.0403795101
P407
P577
2004-06-28T00:00:00Z