Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control. - Wikidata - wikimedia - TriplyDB

Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control.

Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control.

http://www.wikidata.org/entity/Q37054526

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Tuberculosis and HIV co-infection IL-28B/IFN-lambda 3 drives granzyme B loading and significantly increases CTL killing activity in macaques Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection Association of HLA-alleles with the immune regulation of chronic viral infections Tissue-resident memory T cells Systems biology applied to vaccine and immunotherapy development Distinct roles of CD4+ T cell subpopulations in retroviral immunity: lessons from the Friend virus mouse model The role of interleukin-21 in HIV infection The enduring tale of T cells in HIV immunopathogenesis SAMHD1 Limits HIV-1 Antigen Presentation by Monocyte-Derived Dendritic Cells.High avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral function GagCM9-specific CD8+ T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivo Broad and potent neutralization of HIV-1 by a gp41-specific human antibody Cellular immune responses and susceptibility to HIV-1 superinfection: a case-control study CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21 Inhibitory potential of subpopulations of CD8+ T cells in HIV-1-infected elite suppressors Long-term programming of antigen-specific immunity from gene expression signatures in the PBMC of rhesus macaques immunized with an SIV DNA vaccine Efficacious early antiviral activity of HIV Gag- and Pol-specific HLA-B 2705-restricted CD8+ T cells Immune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?Vaccine design for CD8 T lymphocyte responses Pushing the frontiers of T-cell vaccines: accurate measurement of human T-cell responses.HIV-1 Vaccine Trials: Evolving Concepts and Designs CD8(+) T-cell effector function and transcriptional regulation during HIV pathogenesis Transient nature of long-term nonprogression and broad virus-specific proliferative T-cell responses with sustained thymic output in HIV-1 controllers HIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidity.Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control.Induction of Potent and Long-Lived Antibody and Cellular Immune Responses in the Genitorectal Mucosa Could be the Critical Determinant of HIV Vaccine Efficacy.Characterization of T-cell responses in macaques immunized with a single dose of HIV DNA vaccine Breadth of human immunodeficiency virus-specific neutralizing activity in sera: clustering analysis and association with clinical variables Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustion Unexpected diversity of cellular immune responses against Nef and Vif in HIV-1-infected patients who spontaneously control viral replication Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection.Timing of immune escape linked to success or failure of vaccination.Functional avidity and IL-2/perforin production is linked to the emergence of mutations within HLA-B*5701-restricted epitopes and HIV-1 disease progression Proliferation capacity and cytotoxic activity are mediated by functionally and phenotypically distinct virus-specific CD8 T cells defined by interleukin-7R{alpha} (CD127) and perforin expression.Correlating cellular and molecular signatures of mucosal immunity that distinguish HIV controllers from noncontrollers.Factors Associated With the Control of Viral Replication and Virologic Breakthrough in a Recently Infected HIV-1 Controller A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers.T-cell correlates of vaccine efficacy after a heterologous simian immunodeficiency virus challenge.Phenotypic and functional profile of HIV-inhibitory CD8 T cells elicited by natural infection and heterologous prime/boost vaccination

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Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control.

http://www.wikidata.org/entity/Q37054526

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 08 December 2008

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Lytic granule loading of CD8+ ...... ssociated with immune control.

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Lytic granule loading of CD8+ ...... ssociated with immune control.

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type

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Lytic granule loading of CD8+ ...... ssociated with immune control.

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Lytic granule loading of CD8+ ...... ssociated with immune control.

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prefLabel

Lytic granule loading of CD8+ ...... ssociated with immune control.

@en

Lytic granule loading of CD8+ ...... ssociated with immune control.

@nl

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J.IMMUNI.2008.10.010

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Lytic granule loading of CD8+ ...... ssociated with immune control.

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Akira Komoriya

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Amy M Berkley

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Ann P Wiegand

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Beverly Z Packard

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Cassandra Royce

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Catherine Rehm

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Christine M Osborne

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Dean A Follman

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Frank Maldarelli

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Gregg Roby

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P2860

HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors

Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection

Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells

HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

HIV-1-specific IFN-gamma/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells.

Resistance to replication of human immunodeficiency virus challenge in SCID-Hu mice engrafted with peripheral blood mononuclear cells of nonprogressors is mediated by CD8(+) T cells and associated with a proliferative response to p24 antigen.

Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection

Structured antiretroviral treatment interruptions in chronically HIV-1-infected subjects.

Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment

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1009-1021

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scholarly article

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10.1016/J.IMMUNI.2008.10.010

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6

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Claire W Hallahan

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2008-12-08T00:00:00Z

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23629371

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19062316

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