Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking.
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Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brainNative α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2Versatile Structures of α-SynucleinAlpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons DiseaseBiophysical characterization of α-synuclein and its controversial structureThe Synaptic Function of α-SynucleinAlpha-Synuclein Oligomers-Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body DisordersAlpha-synuclein structure, functions, and interactionsSeeking a mechanism for the toxicity of oligomeric α-synucleinThe phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's diseaseVesicular integrity in Parkinson's diseaseDopamine-induced α-synuclein oligomers show self- and cross-propagation properties.Convergence of pathology in dementia with Lewy bodies and Alzheimer's disease: a role for the novel interaction of alpha-synuclein and presenilin 1 in disease.Nonaggregated α-synuclein influences SNARE-dependent vesicle docking via membrane binding.Synucleins regulate the kinetics of synaptic vesicle endocytosis.Beta-amyloid oligomers activate apoptotic BAK pore for cytochrome c release.Alpha-synuclein function and dysfunction on cellular membranes.Dynamin1 concentration in the prefrontal cortex is associated with cognitive impairment in Lewy body dementiaEnvironmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD.β-Amyloid and α-synuclein cooperate to block SNARE-dependent vesicle fusionReal-time submillisecond single-molecule FRET dynamics of freely diffusing molecules with liposome tethering.Biophysics of α-synuclein induced membrane remodellingAggregated Alpha-Synuclein Transfer Efficiently between Cultured Human Neuron-Like Cells and Localize to LysosomesTowards reconstitution of membrane fusion mediated by SNAREs and other synaptic proteinsDT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity.α-Synuclein can inhibit SNARE-mediated vesicle fusion through direct interactions with lipid bilayers.Age- and brain region-dependent α-synuclein oligomerization is attributed to alterations in intrinsic enzymes regulating α-synuclein phosphorylation in aging monkey brains.Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerationsSynaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.Neurodegenerative Disease Related Proteins Have Negative Effects on SNARE-Mediated Membrane Fusion in Pathological Confirmation.Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies.Synaptic failure and α-synuclein.Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivoSoluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress.The role of Ca2+ signaling in Parkinson's disease.Animal models of α-synucleinopathy for Parkinson disease drug development.Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson's disease.A critical role for alpha-synuclein in development and function of T lymphocytes.Late stages of hematopoiesis and B cell lymphopoiesis are regulated by α-synuclein, a key player in Parkinson's disease.Amyloid-β Oligomers May Impair SNARE-Mediated Exocytosis by Direct Binding to Syntaxin 1a.
P2860
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P2860
Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking.
@ast
Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking.
@en
type
label
Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking.
@ast
Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking.
@en
prefLabel
Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking.
@ast
Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking.
@en
P2093
P2860
P356
P1476
Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking.
@en
P2093
Bong-Kyu Choi
Dae-Hyuk Kweon
Jae-Yeol Kim
Mal-Gi Choi
Nam Ki Lee
Yeon-Kyun Shin
Yoosoo Yang
P2860
P304
P356
10.1073/PNAS.1218424110
P407
P577
2013-02-19T00:00:00Z