Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.
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eIF4G is required for the pioneer round of translation in mammalian cellsHuman ASPM participates in spindle organisation, spindle orientation and cytokinesis.The human PAF complex coordinates transcription with events downstream of RNA synthesis.Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 proteinThe neurofibromatosis type I messenger RNA undergoes base-modification RNA editingNovel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexesA mutation in the surfactant protein B gene responsible for fatal neonatal respiratory disease in multiple kindredsHuman triosephosphate isomerase deficiency resulting from mutation of Phe-240The molecular basis of HEXA mRNA deficiency caused by the most common Tay-Sachs disease mutationIntegration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway.The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm.Nonsense-mediated mRNA decay in humans at a glanceA simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complexOrganizing principles of mammalian nonsense-mediated mRNA decayRapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathwaymRNA stability in mammalian cellsFrameshift mutations in the v-src gene of avian sarcoma virus act in cis to specifically reduce v-src mRNA levels.mRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization?Frame-disrupting mutations elicit pre-mRNA accumulation independently of frame disruptionGenome annotation for clinical genomic diagnostics: strengths and weaknessesIntranuclear degradation of nonsense codon-containing mRNAAt least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation.The tripartite leader sequence of subgroup C adenovirus major late mRNAs can increase the efficiency of mRNA export.Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA.A premature termination codon interferes with the nuclear function of an exon splicing enhancer in an open reading frame-dependent mannerMultiple splicing defects in an intronic false exon.Nonsense-mediated decay of human HEXA mRNA.Unspliced precursors of NMD-sensitive β-globin transcripts exhibit decreased steady-state levels in erythroid cellsThe application of nonsense-mediated mRNA decay inhibition to the identification of breast cancer susceptibility genesSearching for the 1 in 2,400,000: a review of dystrophin gene point mutations.Evidence that the decay of nucleus-associated nonsense mRNA for human triosephosphate isomerase involves nonsense codon recognition after splicing.Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm.Cis-acting elements are required for selenium regulation of glutathione peroxidase-1 mRNA levels.Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay.Premature termination codons do not affect the rate of splicing of neighboring introns.mRNA transport in yeast: time to reinvestigate the functions of the nucleolus.Nonsense-containing mRNAs that accumulate in the absence of a functional nonsense-mediated mRNA decay pathway are destabilized rapidly upon its restitutionSC35 autoregulates its expression by promoting splicing events that destabilize its mRNAsQuality control of gene expression in the nucleus.When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.
P2860
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P2860
Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Nonsense codons can reduce the ...... half-life of cytoplasmic mRNA.
@ast
Nonsense codons can reduce the ...... half-life of cytoplasmic mRNA.
@en
type
label
Nonsense codons can reduce the ...... half-life of cytoplasmic mRNA.
@ast
Nonsense codons can reduce the ...... half-life of cytoplasmic mRNA.
@en
prefLabel
Nonsense codons can reduce the ...... half-life of cytoplasmic mRNA.
@ast
Nonsense codons can reduce the ...... half-life of cytoplasmic mRNA.
@en
P2860
P356
P1476
Nonsense codons can reduce the ...... half-life of cytoplasmic mRNA.
@en
P2093
P2860
P304
P356
10.1128/MCB.13.3.1892
P407
P577
1993-03-01T00:00:00Z