The murine myeloperoxidase promoter contains several functional elements, one of which binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1).
about
Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk geneEarly myeloid cell-specific expression of the human cathepsin G gene in transgenic miceAlternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemiaAML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoterPU.1 and USF are required for macrophage-specific mannose receptor promoter activityA novel gene, FGA7, is fused to RUNX1/AML1 in a t(4;21)(q28;q22) in a patient with T-cell acute lymphoblastic leukemia.Myeloperoxidase gene expression and regulation by myeloid cell growth factors in normal and leukemic cells.Runx1, c-Myb, and C/EBPalpha couple differentiation to proliferation or growth arrest during hematopoiesis.AP-1 protein induction during monopoiesis favors C/EBP: AP-1 heterodimers over C/EBP homodimerization and stimulates FosB transcriptionThe +37 kb Cebpa Enhancer Is Critical for Cebpa Myeloid Gene Expression and Contains Functional Sites that Bind SCL, GATA2, C/EBPα, PU.1, and Additional Ets Factors.In Vivo Deletion of the Cebpa +37 kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis.Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis.Restriction of interferon gamma responsiveness and basal expression of the myeloid human Fc gamma R1b gene is mediated by a functional PU.1 site and a transcription initiator consensusC/EBPalpha binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment.Cell cycle and developmental control of hematopoiesis by Runx1.c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor delta enhancer.PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentialsThe t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation.The increased level of beta1,4-galactosyltransferase required for lactose biosynthesis is achieved in part by translational controlRegulation of the myeloperoxidase enhancer binding proteins Pu1, C-EBP alpha, -beta, and -delta during granulocyte-lineage specification.PU.1 and partners: regulation of haematopoietic stem cell fate in normal and malignant haematopoiesis.An AML-1 consensus sequence binds an osteoblast-specific complex and transcriptionally activates the osteocalcin gene.PU.1 and an HLH family member contribute to the myeloid-specific transcription of the Fc gamma RIIIA promoterAn acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms.Casein kinase II phosphorylation site mutations in c-Myb affect DNA binding and transcriptional cooperativity with NF-M.Transcriptional activity of core binding factor-alpha (AML1) and beta subunits on murine leukemia virus enhancer cores.PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells.Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors.Binding of NF-Y transcription factor to one of the cis-elements in the myeloperoxidase gene promoter that responds to granulocyte colony-stimulating factor.Erythroid Krüppel-like factor (EKLF) contains a multifunctional transcriptional activation domain important for inter- and intramolecular interactions.Structural and functional characterization of the human CD36 gene promoter: identification of a proximal PEBP2/CBF site.The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation.Multimerization via its myosin domain facilitates nuclear localization and inhibition of core binding factor (CBF) activities by the CBFbeta-smooth muscle myosin heavy chain myeloid leukemia oncoprotein.Transcriptional activation of a retrovirus enhancer by CBF (AML1) requires a second factor: evidence for cooperativity with c-Myb.The potent enhancer activity of the polycythemic strain of spleen focus-forming virus in hematopoietic cells is governed by a binding site for Sp1 in the upstream control region and by a unique enhancer core motif, creating an exclusive target for PC/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter.Core binding factor cannot synergistically activate the myeloperoxidase proximal enhancer in immature myeloid cells without c-Myb.Hematopoietic lineage commitment: role of transcription factors.AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression.Myeloperoxidase gene expression in normal granulopoiesis and acute leukemias.
P2860
Q24309536-BD451871-B84F-4676-B317-CE38714A15F2Q24564002-5941B21A-E047-4474-AE4A-C5C4E99A5C24Q24626212-47DBBDA8-AC82-4831-BDBC-CA5385595E66Q28142631-E30D964B-B015-4006-8584-912E21ACBFCAQ28572078-361782C3-4497-49E5-8D2E-06BE8A3E5F06Q30747544-F0099478-EA57-4DBF-B143-7B1DDEBCD0C8Q33536303-5946DF79-2B58-4B22-8913-5114D650E8FCQ34811848-21337A13-7670-4800-92A3-3298310B03E6Q35225359-D5566274-9E2D-4A13-BC77-14E2AEC6963EQ35566633-12CD2BCE-99B6-4E95-BE1E-C096EB5F5574Q35944184-73E9F825-B3AF-4F2A-A751-A787371E78EEQ35995201-68CC5AF6-1D53-4A6C-A50F-D33A4060A9EFQ36363233-18724AEA-78C0-4DCA-946A-3A4C5D4D0362Q36384868-A180EF81-1073-4380-B8AD-F60D715D172DQ36543603-168D2FA3-42BD-4492-BAF4-DC6908CE0ABFQ36551352-73DF0F6F-EBB5-4CC1-87D8-580C657CAEA9Q36652625-C44CA4A2-2A46-4AD9-AF89-3782496D1899Q36719874-8793A100-296D-40F0-AFE3-44C0C2F62976Q36755111-D40511B5-DB2B-4A61-92B5-A261494A1E98Q37298357-9D8367C8-55D3-4D32-BFAB-90BBB16BF808Q37453513-088C9111-3199-4E11-9417-64716A1BA87CQ37610593-12D4EBFA-9237-44F6-BFC2-984933FC2C4DQ37635523-AF0340FE-A49E-4AB7-A956-57EA0628AA61Q37693756-70B62B87-98DD-4779-8EE7-47C1E52661B2Q38289938-D37398BA-0628-4EEB-8129-B871EDA3480CQ38296037-64ED7D37-1D29-4CE6-AF3F-F15DC3F47953Q38305735-2308AB5D-C613-4078-9E13-04CB92854DF4Q38312442-87EE8E98-DC81-4C94-8233-DD9A09F633BDQ38343156-A93CFEFC-AB0A-4C00-9357-4EAEFAE6BDF8Q38351856-F1CDFE46-201D-49D6-BB71-D9368AC9E7DAQ38360015-F030DD2A-E412-470B-9959-E17D1B4B9EE8Q39631307-0ABB083E-4D99-4F2C-A809-4AC325084D37Q39675523-65F7C76D-F53E-4660-8FE9-BF674DDCE353Q39875687-84E13AFE-E739-44B5-9511-487C0EBE090FQ39880731-0097EDA2-AE42-43A9-A3C2-F0C050EF6C3CQ40019700-1267FE2E-9A75-4CA7-AD51-497B47CD55D4Q40023226-A1CDE664-9530-4A86-A309-D85DCEA3AC06Q40445971-09C4895A-17FC-4475-9435-44AF1118EEECQ40595051-FB24DAC8-62F6-40C0-9225-A585382BC669Q40599143-6B4C1F52-2D4F-4731-B4A4-DC7CD5C27CFF
P2860
The murine myeloperoxidase promoter contains several functional elements, one of which binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1).
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
The murine myeloperoxidase pro ...... loid nuclear factor 1 (MyNF1).
@ast
The murine myeloperoxidase pro ...... loid nuclear factor 1 (MyNF1).
@en
type
label
The murine myeloperoxidase pro ...... loid nuclear factor 1 (MyNF1).
@ast
The murine myeloperoxidase pro ...... loid nuclear factor 1 (MyNF1).
@en
prefLabel
The murine myeloperoxidase pro ...... loid nuclear factor 1 (MyNF1).
@ast
The murine myeloperoxidase pro ...... loid nuclear factor 1 (MyNF1).
@en
P2860
P356
P1476
The murine myeloperoxidase pro ...... loid nuclear factor 1 (MyNF1).
@en
P2093
P2860
P304
P356
10.1128/MCB.13.4.2141
P407
P577
1993-04-01T00:00:00Z