Multimerization via its myosin domain facilitates nuclear localization and inhibition of core binding factor (CBF) activities by the CBFbeta-smooth muscle myosin heavy chain myeloid leukemia oncoprotein.
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The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain.Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia.PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesisCell cycle and developmental control of hematopoiesis by Runx1.The C-terminus of CBFβ-SMMHC is required to induce embryonic hematopoietic defects and leukemogenesisRoles of p15Ink4b and p16Ink4a in myeloid differentiation and RUNX1-ETO-associated acute myeloid leukemiaCore binding factor at the crossroads: determining the fate of the HSC.Targeting binding partners of the CBFβ-SMMHC fusion protein for the treatment of inversion 16 acute myeloid leukemia.Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability.Identification of a region on the outer surface of the CBFbeta-SMMHC myeloid oncoprotein assembly competence domain critical for multimerization.AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression.Rad52 multimerization is important for its nuclear localization in Saccharomyces cerevisiae.CBFbeta-SMMHC slows proliferation of primary murine and human myeloid progenitors.The assembly competence domain is essential for inv(16)-associated acute myeloid leukemia.The C-terminal multimerization domain is essential for leukemia development by CBFβ-SMMHC in a mouse knockin model.Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia.
P2860
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P2860
Multimerization via its myosin domain facilitates nuclear localization and inhibition of core binding factor (CBF) activities by the CBFbeta-smooth muscle myosin heavy chain myeloid leukemia oncoprotein.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Multimerization via its myosin ...... myeloid leukemia oncoprotein.
@en
Multimerization via its myosin ...... ibition of core binding factor
@nl
type
label
Multimerization via its myosin ...... myeloid leukemia oncoprotein.
@en
Multimerization via its myosin ...... ibition of core binding factor
@nl
prefLabel
Multimerization via its myosin ...... myeloid leukemia oncoprotein.
@en
Multimerization via its myosin ...... ibition of core binding factor
@nl
P2093
P2860
P1476
Multimerization via its myosin ...... myeloid leukemia oncoprotein.
@en
P2093
Alan D Friedman
Jianrong Lou
Tanawan Kummalue
P2860
P304
P356
10.1128/MCB.22.23.8278-8291.2002
P407
P577
2002-12-01T00:00:00Z