Functional characterization of the developmentally controlled immunoglobulin kappa 3' enhancer: regulation by Id, a repressor of helix-loop-helix transcription factors.
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E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells.Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 siteE2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 proteinAKT induces transcriptional activity of PU.1 through phosphorylation-mediated modifications within its transactivation domainNovel regulation of the helix-loop-helix protein Id1 by S5a, a subunit of the 26 S proteasomeActivating transcription factor 1 and cyclic AMP response element modulator can modulate the activity of the immunoglobulin kappa 3' enhancerMurine helix-loop-helix transcriptional activator proteins binding to the E-box motif of the Akv murine leukemia virus enhancer identified by cDNA cloningPrf, a novel Ets family protein that binds to the PU.1 binding motif, is specifically expressed in restricted stages of B cell development.Activation of c-myc promoter P1 by immunoglobulin kappa gene enhancers in Burkitt lymphoma: functional characterization of the intron enhancer motifs kappaB, E box 1 and E box 2, and of the 3' enhancer motif PU.Long-range interactions between three transcriptional enhancers, active Vkappa gene promoters, and a 3' boundary sequence spanning 46 kilobasesNormal myeloid development requires both the glutamine-rich transactivation domain and the PEST region of transcription factor PU.1 but not the potent acidic transactivation domain.BSAP can repress enhancer activity by targeting PU.1 function.Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.EBV-encoded LMP1 upregulates Igκ 3'enhancer activity and Igκ expression in nasopharyngeal cancer cells by activating the Ets-1 through ERKs signaling.The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3Expression and differential regulation of Id1, a dominant negative regulator of basic helix-loop-helix transcription factors, in glomerular mesangial cells.Regulation of activation and recombination of the murine Igkappa locus.Various modes of basic helix-loop-helix protein-mediated regulation of murine leukemia virus transcription in lymphoid cell lines.Selective synergy of immunoglobulin enhancer elements in B-cell development: a characteristic of kappa light chain enhancers, but not heavy chain enhancersPU.1 can participate in an active enhancer complex without its transcriptional activation domain.Antisense SCL suppresses self-renewal and enhances spontaneous erythroid differentiation of the human leukaemic cell line K562.Transcription of the dominant-negative helix-loop-helix protein Id1 is regulated by a protein complex containing the immediate-early response gene Egr-1.A developmentally modulated chromatin structure at the mouse immunoglobulin kappa 3' enhancer.Regulation of the pro-B-cell-specific enhancer of the Id1 gene involves the C/EBP family of proteins.High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice.Characterization of the human immunoglobulin kappa gene 3' enhancer: functional importance of three motifs that demonstrate B-cell-specific in vivo footprintsPU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3' enhancer activity.Transforming growth factor-beta: an important mediator of immunoregulation.A novel enhancer, the pro-B enhancer, regulates Id1 gene expression in progenitor B cellsDevelopmental regulation of the kappa locus involves both positive and negative sequence elements in the 3' enhancer that affect synergy with the intron enhancer.Two isoforms of protein disulfide isomerase alter the dimerization status of E2A proteins by a redox mechanism.PU.1 Regulates Ig Light Chain Transcription and Rearrangement in Pre-B Cells during B Cell Development.YY1 controls immunoglobulin class switch recombination and nuclear activation-induced deaminase levels.A developmentally controlled competitive STAT5-PU.1 DNA binding mechanism regulates activity of the Ig κ E3' enhancer.Transcription factor Pip can enhance DNA binding by E47, leading to transcriptional synergy involving multiple protein domainsMechanism of e47-Pip interaction on DNA resulting in transcriptional synergy and activation of immunoglobulin germ line sterile transcripts.Octamer independent activation of transcription from the kappa immunoglobulin germline promoter.E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas.The chicken immunoglobulin lambda light chain gene is transcriptionally controlled by a modularly organized enhancer and an octamer-dependent silencer.Activation of the immunoglobulin kappa 3' enhancer in pre-B cells correlates with the suppression of a nuclear factor binding to a sequence flanking the active core.
P2860
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P2860
Functional characterization of the developmentally controlled immunoglobulin kappa 3' enhancer: regulation by Id, a repressor of helix-loop-helix transcription factors.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Functional characterization of ...... p-helix transcription factors.
@ast
Functional characterization of ...... p-helix transcription factors.
@en
type
label
Functional characterization of ...... p-helix transcription factors.
@ast
Functional characterization of ...... p-helix transcription factors.
@en
prefLabel
Functional characterization of ...... p-helix transcription factors.
@ast
Functional characterization of ...... p-helix transcription factors.
@en
P2860
P356
P1476
Functional characterization of ...... p-helix transcription factors.
@en
P2093
J M Pongubala
M L Atchison
P2860
P304
P356
10.1128/MCB.11.2.1040
P407
P577
1991-02-01T00:00:00Z