Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers. - Wikidata - wikimedia - TriplyDB

Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.

Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.

http://www.wikidata.org/entity/Q33886982

about

Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells.AID targeting is dependent on RNA polymerase II pausing.A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination.A nuclear matrix attachment region upstream of the T cell receptor beta gene enhancer binds Cux/CDP and SATB1 and modulates enhancer-dependent reporter gene expression but not endogenous gene expression Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2 AID and Apobec3G haphazard deamination and mutational diversity A coming-of-age story: activation-induced cytidine deaminase turns 10.Transcription, beta-like DNA polymerases and hypermutation Genome-wide somatic hypermutation.Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells In vivo and in vitro studies of immunoglobulin gene somatic hypermutation.Targeting of somatic hypermutation.AID and mismatch repair in antibody diversification.AID to overcome the limitations of genomic information by introducing somatic DNA alterations.Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences.What role for AID: mutator, or assembler of the immunoglobulin mutasome?Immunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair.Flanking nuclear matrix attachment regions synergize with the T cell receptor delta enhancer to promote V(D)J recombination The Ig mutator is dependent on the presence, position, and orientation of the large intron enhancer.Both DNA strands of antibody genes are hypermutation targets.Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences.H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase.Defect in IgV gene somatic hypermutation in common variable immuno-deficiency syndrome Multiple transcription factor binding sites predict AID targeting in non-Ig genes Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes.Histone H3.3 promotes IgV gene diversification by enhancing formation of AID-accessible single-stranded DNA.The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially.AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line.Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes.PMA/ionomycin induces Ig kappa 3' enhancer activity which is in part mediated by a unique NFAT transcription complex.PU.1 can recruit BCL6 to DNA to repress gene expression in germinal center B cells.DNA polymerase mu gene expression in B-cell non-Hodgkin's lymphomas: an analysis utilizing in situ hybridization.The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process.Stabilised DNA secondary structures with increasing transcription localise hypermutable bases for somatic hypermutation in IGHV3-23.Somatic hypermutation in normal and transformed human B cells.Affinity selection and repertoire shift: paradoxes as a consequence of somatic mutation?Dual enigma of somatic hypermutation of immunoglobulin variable genes: targeting and mechanism.

P2860

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P2860

Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.

http://www.wikidata.org/entity/Q33886982

description

1997 nî lūn-bûn

@nan

1997 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

1997 թվականի հուլիսին հրատարակված գիտական հոդված

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1997年の論文

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1997年学术文章

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1997年学术文章

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1997年学术文章

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1997年学术文章

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1997年学术文章

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1997年學術文章

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name

Cells strongly expressing Ig(k ...... or both MAR and the enhancers.

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Cells strongly expressing Ig(k ...... or both MAR and the enhancers.

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type

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Cells strongly expressing Ig(k ...... or both MAR and the enhancers.

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Cells strongly expressing Ig(k ...... or both MAR and the enhancers.

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Cells strongly expressing Ig(k ...... or both MAR and the enhancers.

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Cells strongly expressing Ig(k ...... or both MAR and the enhancers.

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P1433

The EMBO Journal

P1476

Cells strongly expressing Ig(k ...... for both MAR and the enhancers

@en

P2093

Goyenechea B

http://www.w3.org/2001/XMLSchema#string

Klix N

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Milstein C

http://www.w3.org/2001/XMLSchema#string

Neuberger MS

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Riddell A

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Williams GT

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P2860

Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites.

Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation.

A developmentally modulated chromatin structure at the mouse immunoglobulin kappa 3' enhancer.

Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes

Functional characterization of the developmentally controlled immunoglobulin kappa 3' enhancer: regulation by Id, a repressor of helix-loop-helix transcription factors.

Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer

Fine mapping of an immunoglobulin gene activator

Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangement.

Dependence of enhancer-mediated transcription of the immunoglobulin mu gene on nuclear matrix attachment regions.

The enhancer of the immunoglobulin heavy chain locus is flanked by presumptive chromosomal loop anchorage elements.

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3987-3994

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scholarly article

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10.1093/EMBOJ/16.13.3987

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13

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16

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1997-07-01T00:00:00Z

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13985559

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9233808

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1170022

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