Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.
about
Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells.AID targeting is dependent on RNA polymerase II pausing.A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination.A nuclear matrix attachment region upstream of the T cell receptor beta gene enhancer binds Cux/CDP and SATB1 and modulates enhancer-dependent reporter gene expression but not endogenous gene expressionIncreased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair proteinAltered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2AID and Apobec3G haphazard deamination and mutational diversityA coming-of-age story: activation-induced cytidine deaminase turns 10.Transcription, beta-like DNA polymerases and hypermutationGenome-wide somatic hypermutation.Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cellsIn vivo and in vitro studies of immunoglobulin gene somatic hypermutation.Targeting of somatic hypermutation.AID and mismatch repair in antibody diversification.AID to overcome the limitations of genomic information by introducing somatic DNA alterations.Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences.What role for AID: mutator, or assembler of the immunoglobulin mutasome?Immunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair.Flanking nuclear matrix attachment regions synergize with the T cell receptor delta enhancer to promote V(D)J recombinationThe Ig mutator is dependent on the presence, position, and orientation of the large intron enhancer.Both DNA strands of antibody genes are hypermutation targets.Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences.H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutationSomatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase.Defect in IgV gene somatic hypermutation in common variable immuno-deficiency syndromeMultiple transcription factor binding sites predict AID targeting in non-Ig genesHepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes.Histone H3.3 promotes IgV gene diversification by enhancing formation of AID-accessible single-stranded DNA.The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially.AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line.Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes.PMA/ionomycin induces Ig kappa 3' enhancer activity which is in part mediated by a unique NFAT transcription complex.PU.1 can recruit BCL6 to DNA to repress gene expression in germinal center B cells.DNA polymerase mu gene expression in B-cell non-Hodgkin's lymphomas: an analysis utilizing in situ hybridization.The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- miceThe activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process.Stabilised DNA secondary structures with increasing transcription localise hypermutable bases for somatic hypermutation in IGHV3-23.Somatic hypermutation in normal and transformed human B cells.Affinity selection and repertoire shift: paradoxes as a consequence of somatic mutation?Dual enigma of somatic hypermutation of immunoglobulin variable genes: targeting and mechanism.
P2860
Q27469843-DA906D67-BFC5-4C18-B103-FB6DDEA85807Q27692655-1E5DB0A6-408D-48F7-9833-841298B82EF8Q27936954-4C172985-91EF-4541-A937-0E85174B167FQ28287052-422B3CFD-E627-4979-907B-1447F7C97FD5Q28505917-819C95A5-AD1E-4D09-A6D6-9CFA0F1B10D9Q28910215-06D5AC57-57EC-4E9E-81E0-3B2CCF343EECQ30537745-6EA0CBE7-CD01-46A0-877E-2164F2A4F728Q33605445-A06387CB-5E27-4A50-8209-00762AA53954Q33770295-891178CC-AB48-464C-9D0F-809E3B93F519Q33905110-AC7EF348-103A-407C-B6E3-A66C7331D15AQ33920280-9E4B304F-ADB8-402C-B2A7-A2A0CA5A1BBBQ34155290-2E8B1286-EFEB-4916-9EC6-950510646DB0Q34551108-00BD5B79-7F35-4BAB-A36D-2208470B49F9Q34770418-279CA3EE-EE2C-43FF-B903-2C450BD02325Q35068183-BEF2F7D1-9B20-4921-887F-54A9A7D9BD7CQ35137494-D3D78D14-F026-469A-9602-7F68A4F65E17Q35164207-32FDC9D1-C490-4FD4-AB1E-5C5A5CF55105Q35213276-94007943-CF5D-4127-817D-95A074B89889Q35727029-0DE91DEA-EFF9-4DA2-91A6-0011DDE92545Q35917705-813E1EF9-2041-448A-9652-6273748DB84FQ36220380-A2330588-E777-42F1-8380-23D2D0A17CB3Q36228204-C0E35940-529E-4475-9FE2-622A060095B8Q36370913-25F45874-1FFE-4145-AB78-66148F1B422EQ36399510-694E46E6-E00F-4B69-81B1-8986134A6191Q36639355-78BA6D42-B55A-4091-B820-C27131D7C388Q36946108-53A302A2-3934-4BB7-9B93-F1F91865EB7AQ37356991-4401A7BF-6C98-4E95-AE7B-34DF1695F4B6Q38768802-D8982726-8073-48E4-A2B1-E6C18890C57BQ39645618-862AA9FB-DB55-45FC-9444-25C2B249B6A2Q40714843-0B10CD80-1997-4887-A1B8-73D65FE5589CQ40840741-6C55745D-D828-4270-BC46-0A1F0F09FF9EQ41039685-1E665349-DD66-4EEB-B7EA-353362101099Q41824952-82018DBB-2960-4444-890E-1953A8156B4CQ41898633-564A9633-19E5-42F4-BBBD-B91700FE76D1Q42286497-8C9AE2FF-8ED7-46A1-888F-79CB8D233C88Q42944711-403D4995-299B-4342-85B6-F8D39F7B4BFBQ44623657-995F5E15-D8C8-4598-BB64-F48BD91F04BAQ48037869-B32B3F00-58ED-4532-8E64-C9E34793A958Q52039313-56A5983B-85DB-44F0-B6C8-A17CF9E486BFQ52902753-9E26D6E7-BF38-47CD-BE17-9BD59F905D23
P2860
Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.
description
1997 nî lūn-bûn
@nan
1997 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
name
Cells strongly expressing Ig(k ...... or both MAR and the enhancers.
@ast
Cells strongly expressing Ig(k ...... or both MAR and the enhancers.
@en
type
label
Cells strongly expressing Ig(k ...... or both MAR and the enhancers.
@ast
Cells strongly expressing Ig(k ...... or both MAR and the enhancers.
@en
prefLabel
Cells strongly expressing Ig(k ...... or both MAR and the enhancers.
@ast
Cells strongly expressing Ig(k ...... or both MAR and the enhancers.
@en
P2093
P2860
P356
P1433
P1476
Cells strongly expressing Ig(k ...... for both MAR and the enhancers
@en
P2093
Goyenechea B
Milstein C
Neuberger MS
Williams GT
P2860
P304
P356
10.1093/EMBOJ/16.13.3987
P407
P50
P577
1997-07-01T00:00:00Z