EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma. - Wikidata - wikimedia - TriplyDB

EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma.

EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma.

http://www.wikidata.org/entity/Q36696146

about

Molecular therapeutics in pancreas cancer The Significance of Ras Activity in Pancreatic Cancer Initiation Genetics and biology of pancreatic ductal adenocarcinoma GEMMs as preclinical models for testing pancreatic cancer therapies Perspectives in the treatment of pancreatic adenocarcinoma Molecular Targeted Intervention for Pancreatic Cancer Genetically engineered mouse models of pancreatic adenocarcinoma The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas ADAM8 as a drug target in pancreatic cancer.Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression.Utilizing past and present mouse systems to engineer more relevant pancreatic cancer models Transcriptional regulation of fibronectin by p21-activated kinase-1 modulates pancreatic tumorigenesis Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation Co-treatment with panitumumab and trastuzumab augments response to the MEK inhibitor trametinib in a patient-derived xenograft model of pancreatic cancer TCGA data and patient-derived orthotopic xenografts highlight pancreatic cancer-associated angiogenesis KRAS-dependent suppression of MYC enhances the sensitivity of cancer cells to cytotoxic agents.ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism.Intraductal tubulopapillary neoplasm accompanied by invasive carcinoma of the pancreas: A case report and review of the literature.The quest to overcome resistance to EGFR-targeted therapies in cancer.Inflammation to cancer: The molecular biology in the pancreas (Review).The secret origins and surprising fates of pancreas tumors Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis.Oncogenic KRAS signalling in pancreatic cancer.Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mTOR) and Ras activity in pancreatic cancer: role of specificity protein (Sp) transcription factors.DCLK1 regulates pluripotency and angiogenic factors via microRNA-dependent mechanisms in pancreatic cancer.microRNA-10b enhances pancreatic cancer cell invasion by suppressing TIP30 expression and promoting EGF and TGF-β actions.Smarter drugs emerging in pancreatic cancer therapy.Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions.Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice.Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants.Kras as a key oncogene and therapeutic target in pancreatic cancer Regeneration and repair of the exocrine pancreas.Advanced pancreatic adenocarcinoma: a review of current treatment strategies and developing therapies.Small-molecule modulation of Ras signaling.Mitochondrial uncoupling protein 2 and pancreatic cancer: a new potential target therapy Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization.New targeted therapies in pancreatic cancer.

P2860

Q26751709-341691AD-6C74-4F30-9E63-E44220E7160B Q26765230-E52B5A59-E8D3-4671-858C-97F5785EE956 Q26765438-6C15B739-489F-4327-A70F-0A7AC738FAB0 Q26781848-BA9E5058-4F36-4B2A-AEF3-007AAE780630 Q26797248-2EEFB7B0-F636-4FCB-8E9F-9B6667868196 Q26798453-025A0E0E-E3A1-40F2-B88C-23D3824803D7 Q27002973-D1CAEF82-9234-4668-A2F7-F1E71B6C6422 Q27021883-257C527E-A5FF-409E-8D13-2626EB0703C5 Q27324447-91B6F12F-5A74-4358-9D07-2FD542EB93FF Q27853310-2910EAFE-478C-48C0-B8C1-5EB15A81BE66 Q28083091-ECF11A05-6314-4D7A-AEAE-9215618FCBCE Q28307924-552088E9-E8D9-42EA-89DC-A28BF14D1076 Q28504893-7A8E5EB0-AAA2-47C7-A45A-ADE8FDCB5735 Q28548302-E0DC9476-9735-4020-A462-363237335393 Q30410012-531F2E63-3783-4288-BAE6-6D2578F2F628 Q30908891-D9341C0F-407B-470F-BA9A-03E894954E4E Q33566777-5FDB3925-67E8-4F73-B575-F2EC78E3026C Q33685931-674F6674-8E96-488B-BC30-388DC35DDAFA Q33686279-5592EBF6-0525-4DC2-AA84-40A04606F019 Q33725976-9CF8EF8B-97C1-469C-B9E0-E4490A2642DD Q33727657-16A03239-FD6A-42FA-BF9C-C56BB5273D9A Q33827679-231231EE-DC80-4780-80B5-5AD73B7ADFCF Q33910221-6265A91A-A8B4-4805-992E-1DD0933FB1FA Q34113460-8F6B8BF1-E8BB-43B0-B040-46E388434B9F Q34246014-EDC01B53-F2BB-4EC3-9AFB-3C31A1F1D12A Q34283475-DEE5E83E-56E4-4F1F-B95A-F702ED0CE79D Q34371518-9FFC2CC4-FFCD-4241-99F6-EEA78B0D8188 Q34375528-9921F8FD-7CCE-4B0B-9211-DDFC0B4DCEF7 Q34410212-3524FD3B-853E-4F7C-9940-00BAD0B7F26A Q34517052-BDC498A0-8047-4943-A7F2-83C888564885 Q34590266-7067AFD3-7EEF-420B-A655-017D8D4F18F3 Q34616196-ACB698B8-B117-48AE-BF32-7F6440C7BB3B Q34657670-8432935E-6B7B-459C-B3DF-45ADDEA2F522 Q34659332-CD559432-80DC-4A54-9F38-8BF54A17D4FC Q35071666-D101E628-F04B-40C9-8CBB-9286D54B7188 Q35136815-6A3E80B7-E518-4D36-A60D-B0E28233A385 Q35188280-388BC0D3-0639-4920-85F0-013635EADF0B Q35188581-0B8A4256-23A0-40F6-A15C-688A8DD0CDE3 Q35643021-701E8608-B244-47BC-90FA-4E90123137F8 Q35651453-08AAF379-78FE-4B6E-BD9F-BBB85857C070

P2860

EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma.

http://www.wikidata.org/entity/Q36696146

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

2012年论文

@zh

2012年论文

@zh-cn

name

EGF receptor signaling is esse ...... creatic ductal adenocarcinoma.

@ast

EGF receptor signaling is esse ...... creatic ductal adenocarcinoma.

@en

type

label

EGF receptor signaling is esse ...... creatic ductal adenocarcinoma.

@ast

EGF receptor signaling is esse ...... creatic ductal adenocarcinoma.

@en

prefLabel

EGF receptor signaling is esse ...... creatic ductal adenocarcinoma.

@ast

EGF receptor signaling is esse ...... creatic ductal adenocarcinoma.

@en

P1433

Q36696146-CAEE33AD-8CA0-4C64-992D-199B258CE787

P1476

Q36696146-B138F5CD-9DE7-435E-96F4-A0C52021576E

P2093

Q36696146-4BCAD91E-9B5A-4ECC-9AC6-5302B725A3C9

Q36696146-50F03E11-7177-494C-905F-6EFFE722A564

Q36696146-CA1F29CC-3D42-40CE-9598-89CC3A91F8D0

P2860

Q36696146-02C64BA1-A28C-4246-AA2B-9DFE001C98CE

Q36696146-12700E81-9F54-46DF-982D-2DB6004DB569

Q36696146-1640AF70-F8B3-4BC3-9F6A-3EF4DFA8F2CC

Q36696146-196C03B4-25F9-4311-B8D3-254954B88A49

Q36696146-1E010260-EEBC-445E-AF2E-645A35BA36EB

Q36696146-26C17F01-78F6-4DE2-B42B-8DA445D89F0A

Q36696146-282ABE5C-92C9-43D6-A12C-34E7715297FB

Q36696146-2BBB2EB2-B1F4-4B4B-9027-1F859BFFEF5A

Q36696146-2EA0D7A0-9725-444D-86AE-91127AB85E68

Q36696146-35F5A344-880A-40C9-A76B-59AE3FB65BA8

P304

Q36696146-E79ECEFF-291B-4CD1-A64F-91115BA72CEF

P31

Q36696146-E803B249-0B62-4E93-8446-F3A821D6BE76

P356

Q36696146-D75DEF37-7A96-4849-A2E9-C1B6352DC435

P433

Q36696146-B2C1047F-AFBB-45F0-8E47-F81AE23AC848

P478

Q36696146-C584FB30-D368-4782-9F10-0C7001B57C60

P50

Q36696146-0BC77D17-CA13-46F7-89DD-5B0915550607

Q36696146-15258A4F-7041-470B-9296-C0100B74672D

Q36696146-C66E6D2C-02A2-487F-9DEA-E16FD0BC7890

P577

Q36696146-0A7E1E15-A003-4CAC-BCCE-E2F6801FC89E

P5875

Q36696146-B8317545-A69E-4F55-9E02-9F56FC6CC4F5

P698

Q36696146-F87B35A7-3E3D-4774-AE4F-F25512413156

P921

Q36696146-8497BBAB-9D59-47D4-9940-5020A5AEDCD4

P932

Q36696146-DCDF0A43-1AA5-43E1-8388-9870F8BAE61E

P356

J.CCR.2012.08.001

P1433

P1476

EGF receptor signaling is esse ...... creatic ductal adenocarcinoma.

@en

P2093

Carolina Navas

http://www.w3.org/2001/XMLSchema#string

Isabel Hernández-Porras

http://www.w3.org/2001/XMLSchema#string

Mariano Barbacid

http://www.w3.org/2001/XMLSchema#string

P2860

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

K-ras mutations and benefit from cetuximab in advanced colorectal cancer.

A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.

Untangling the ErbB signalling network

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial

Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers

Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma

Pancreatic cancer

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

P304

318-330

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.CCR.2012.08.001

http://www.w3.org/2001/XMLSchema#string

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

22

http://www.w3.org/2001/XMLSchema#string

P50

Alberto J Schuhmacher

P577

2012-09-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

230848784

http://www.w3.org/2001/XMLSchema#string

P698

22975375

http://www.w3.org/2001/XMLSchema#string

P921

P932

3601542

http://www.w3.org/2001/XMLSchema#string