p59fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain.
about
Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytesAssociation of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophilsMolecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytesCloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 productionRACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cellsAnalysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonanceDual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptorMapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kAssociation of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylationBinding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteinsRAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytesDifferent roles for the Fc epsilon RI gamma chain as a function of the receptor contextT cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T)Lck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid raftsInteractions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motifPhosphorylation site dynamics of early T-cell receptor signalingSequential requirements of the N-terminal palmitoylation site and SH2 domain of Src family kinases in the initiation and progression of FcepsilonRI signaling.The unique amino-terminal domain of p56lck regulates interactions with tyrosine protein phosphatases in T lymphocytesPhysical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fynRapid T-cell receptor-mediated tyrosine phosphorylation of p120, an Fyn/Lck Src homology 3 domain-binding protein.Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.Palmitoylation of p59fyn is reversible and sufficient for plasma membrane associationDistinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha.Multiple features of the p59fyn src homology 4 domain define a motif for immune-receptor tyrosine-based activation motif (ITAM) binding and for plasma membrane localizationDual fatty acylation of p59(Fyn) is required for association with the T cell receptor zeta chain through phosphotyrosine-Src homology domain-2 interactions.Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain.The protein tyrosine kinase p56lck regulates thymocyte development independently of its interaction with CD4 and CD8 coreceptors [corrected]p56lck interacts via its src homology 2 domain with the ZAP-70 kinase.Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation.Lck domains differentially contribute to pre-T cell receptor (TCR)- and TCR-alpha/beta-regulated developmental transitionsCysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae.Unique catalytic properties dictate the enhanced function of p59fynT, the hemopoietic cell-specific isoform of the Fyn tyrosine protein kinase, in T cells.Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins.Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity.A new pathway of CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of Fyn kinase.The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality.Differential T-cell antigen receptor signaling mediated by the Src family kinases Lck and Fyn.14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity.
P2860
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P2860
p59fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
p59fyn tyrosine kinase associa ...... unique amino-terminal domain.
@ast
p59fyn tyrosine kinase associa ...... unique amino-terminal domain.
@en
type
label
p59fyn tyrosine kinase associa ...... unique amino-terminal domain.
@ast
p59fyn tyrosine kinase associa ...... unique amino-terminal domain.
@en
prefLabel
p59fyn tyrosine kinase associa ...... unique amino-terminal domain.
@ast
p59fyn tyrosine kinase associa ...... unique amino-terminal domain.
@en
P2093
P2860
P1476
p59fyn tyrosine kinase associa ...... unique amino-terminal domain.
@en
P2093
Samelson LE
Timson Gauen LK
P2860
P304
P407
P577
1992-12-01T00:00:00Z