Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier.
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Comparative gene identification-58/α/β hydrolase domain 5: more than just an adipose triglyceride lipase activator?Deficiency of a lipid droplet protein, perilipin 5, suppresses myocardial lipid accumulation, thereby preventing type 1 diabetes-induced heart malfunctionPerilipin-5 is regulated by statins and controls triglyceride contents in the hepatocyte.Cellular localization and associations of the major lipolytic proteins in human skeletal muscle at rest and during exercise.PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle.The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid dropletsThe interplay of protein kinase A and perilipin 5 regulates cardiac lipolysis.Perilipin 5 regulates islet lipid metabolism and insulin secretion in a cAMP-dependent manner: implication of its role in the postprandial insulin secretion.Perilipins: lipid droplet coat proteins adapted for tissue-specific energy storage and utilization, and lipid cytoprotectionPerilipin 5-Driven Lipid Droplet Accumulation in Skeletal Muscle Stimulates the Expression of Fibroblast Growth Factor 21Perilipin 5, a lipid droplet protein adapted to mitochondrial energy utilization.Liver Perilipin 5 Expression Worsens Hepatosteatosis But Not Insulin Resistance in High Fat-Fed Mice.Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis.Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial functionLysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid TurnoverPerilipin 5 fine-tunes lipid oxidation to metabolic demand and protects against lipotoxicity in skeletal muscle.Plin5 alleviates myocardial ischaemia/reperfusion injury by reducing oxidative stress through inhibiting the lipolysis of lipid droplets.Lipoprotein lipase activity is required for cardiac lipid droplet production.Lipid Use and Misuse by the Heart.Commentary: Heart Fat Infiltration in Subjects With and Without Coronary Artery DiseaseAdipose triglyceride lipase activity is inhibited by long-chain acyl-coenzyme A.Lipid droplet dynamics and insulin sensitivity upon a 5-day high-fat diet in Caucasians and South AsiansPerilipin 5: putting the brakes on lipolysis.Eat and Death: Chronic Over-Eating.An Overview of Lipid Droplets in Cancer and Cancer Stem Cells.Fatty acids regulate perilipin5 in muscle by activating PPARδDevelopment of hypertrophic cardiomyopathy in perilipin-1 null mice with adipose tissue dysfunction.Cardiac overexpression of perilipin 2 induces dynamic steatosis: prevention by hormone-sensitive lipase.Perilipin 5 mediated lipid droplet remodelling revealed by coherent Raman imaging.The perilipin family of lipid droplet proteins: Gatekeepers of intracellular lipolysis.Perilipin 5 is dispensable for normal substrate metabolism and in the adaptation of skeletal muscle to exercise training.Deciphering the Role of Lipid Droplets in Cardiovascular Disease: A Report From the 2017 National Heart, Lung, and Blood Institute WorkshopLipid Droplets in Cancer: Guardians of Fat in a Stressful World
P2860
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P2860
Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier.
description
2013 nî lūn-bûn
@nan
2013年の論文
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2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Cardiac-specific overexpressio ...... mation of a lipolytic barrier.
@ast
Cardiac-specific overexpressio ...... mation of a lipolytic barrier.
@en
type
label
Cardiac-specific overexpressio ...... mation of a lipolytic barrier.
@ast
Cardiac-specific overexpressio ...... mation of a lipolytic barrier.
@en
prefLabel
Cardiac-specific overexpressio ...... mation of a lipolytic barrier.
@ast
Cardiac-specific overexpressio ...... mation of a lipolytic barrier.
@en
P2093
P2860
P50
P356
P1476
Cardiac-specific overexpressio ...... mation of a lipolytic barrier.
@en
P2093
Dagmar Kolb
Doris Jaeger
Kathrin A Zierler
Manju Kumari
Philipp Markolin
Stephanie Kolleritsch
Thomas Rülicke
P2860
P304
P356
10.1194/JLR.M034710
P50
P577
2013-01-23T00:00:00Z