about
PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humansAdipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman SyndromeEndothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activityCholesteryl ester hydrolase activity is abolished in HSL-/- macrophages but unchanged in macrophages lacking KIAA1363The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymesCrystal structure of the Saccharomyces cerevisiae monoglyceride lipase Yju3pObese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast.Identification of Yju3p as functional orthologue of mammalian monoglyceride lipase in the yeast Saccharomycescerevisiae.Investigation and functional characterization of rare genetic variants in the adipose triglyceride lipase in a large healthy working populationThe serine hydrolase ABHD6 Is a critical regulator of the metabolic syndromeHormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testisAdipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolismIdentification of an insulin-regulated lysophospholipase with homology to neuropathy target esteraseAdiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase.Remodeling of lipid droplets during lipolysis and growth in adipocytesAdipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acidsMonoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice.The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase.Letting lipids go: hormone-sensitive lipase.The minimal domain of adipose triglyceride lipase (ATGL) ranges until leucine 254 and can be activated and inhibited by CGI-58 and G0S2, respectively.Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes.Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase.Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores.A peptide derived from G0/G1 switch gene 2 acts as noncompetitive inhibitor of adipose triglyceride lipase.Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy metabolism.Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance.The interplay of protein kinase A and perilipin 5 regulates cardiac lipolysis.Adipose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of hepatic stellate cells.Structure-activity studies in the development of a hydrazone based inhibitor of adipose-triglyceride lipase (ATGL).ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling.ATGL and CGI-58 are lipid droplet proteins of the hepatic stellate cell line HSC-T6Lipolysis: pathway under construction.Lipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress.Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity.Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice.Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-induced NeuroinflammationCardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier.Functional cardiac lipolysis in mice critically depends on comparative gene identification-58.
P50
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P50
description
hulumtues
@sq
onderzoeker
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researcher
@en
հետազոտող
@hy
name
Robert Zimmermann
@ast
Robert Zimmermann
@en
Robert Zimmermann
@es
Robert Zimmermann
@sl
type
label
Robert Zimmermann
@ast
Robert Zimmermann
@en
Robert Zimmermann
@es
Robert Zimmermann
@sl
prefLabel
Robert Zimmermann
@ast
Robert Zimmermann
@en
Robert Zimmermann
@es
Robert Zimmermann
@sl
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P1153
35785272000
P21
P31
P496
0000-0002-7354-870X