A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gating
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Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal ArthrogryposisIntegrating TRPV1 Receptor Function with Capsaicin PsychophysicsFunctionally important amino acid residues in the transient receptor potential vanilloid 1 (TRPV1) ion channel--an overview of the current mutational dataA pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1.Distinct properties of Ca 2+ –calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channelStructure of the TRPV1 ion channel determined by electron cryo-microscopyTRPV1 structures in distinct conformations reveal activation mechanismsIon-channel modulators: more diversity than previously thoughtFunction and regulation of TRPP2 ion channel revealed by a gain-of-function mutantSearching for interesting channels: pairing selection and molecular evolution methods to study ion channel structure and function.Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain.The basal thermal sensitivity of the TRPV1 ion channel is determined by PKCβII.Bimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation.Thermosensitive TRP channel pore turret is part of the temperature activation pathway.Increased basal activity is a key determinant in the severity of human skeletal dysplasia caused by TRPV4 mutationsAgonist-dependence of functional properties for common nonsynonymous variants of human transient receptor potential vanilloid 1.Forward genetic analysis reveals multiple gating mechanisms of TRPV4High temperature sensitivity is intrinsic to voltage-gated potassium channels.A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domainRole of the outer pore domain in transient receptor potential vanilloid 1 dynamic permeability to large cationsL596-W733 bond between the start of the S4-S5 linker and the TRP box stabilizes the closed state of TRPV4 channel.Multiple modalities converge on a common gate to control K2P channel function.A combined coarse-grained and all-atom simulation of TRPV1 channel gating and heat activationComparative sequence analysis suggests a conserved gating mechanism for TRP channels.Identification of in vivo disulfide conformation of TRPA1 ion channelNovel Alleles of gon-2, a C. elegans Ortholog of Mammalian TRPM6 and TRPM7, Obtained by Genetic Reversion Screens.Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations.Metabolic and thermal stimuli control K(2P)2.1 (TREK-1) through modular sensory and gating domains.Functional and Modeling Studies of the Transmembrane Region of the TRPM8 ChannelMeasuring distances between TRPV1 and the plasma membrane using a noncanonical amino acid and transition metal ion FRETAn external sodium ion binding site controls allosteric gating in TRPV1 channelsStructural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxinThe role of allosteric coupling on thermal activation of thermo-TRP channels.Multiple unbiased prospective screens identify TRP channels and their conserved gating elementsNicotinic acid is a common regulator of heat-sensing TRPV1-4 ion channelsWhat do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?Conserved methionine dictates substrate preference in Nramp-family divalent metal transporters.Proton inhibition of unitary currents of vanilloid receptors.Carboxyl-terminal domain of transient receptor potential vanilloid 1 contains distinct segments differentially involved in capsaicin- and heat-induced desensitization.Hot on the trail of TRP channel structure.
P2860
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P2860
A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gating
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
A yeast genetic screen reveals ...... x domain in TRP channel gating
@ast
A yeast genetic screen reveals ...... x domain in TRP channel gating
@en
type
label
A yeast genetic screen reveals ...... x domain in TRP channel gating
@ast
A yeast genetic screen reveals ...... x domain in TRP channel gating
@en
prefLabel
A yeast genetic screen reveals ...... x domain in TRP channel gating
@ast
A yeast genetic screen reveals ...... x domain in TRP channel gating
@en
P2093
P2860
P1433
P1476
A yeast genetic screen reveals ...... x domain in TRP channel gating
@en
P2093
Benjamin R Myers
Christopher J Bohlen
David Julius
P2860
P304
P356
10.1016/J.NEURON.2008.04.012
P407
P577
2008-05-01T00:00:00Z