The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity
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Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domainElevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomasEps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signalsConstitutive phosphorylation of eps8 in tumor cell lines: relevance to malignant transformationAn effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machineTyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinasesDistinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformationThe erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potencyMechanisms through which Sos-1 coordinates the activation of Ras and Rac.Yes-associated protein (YAP) is differentially expressed in tumor and stroma according to the molecular subtype of breast cancerA single amino acid substitution is sufficient to modify the mitogenic properties of the epidermal growth factor receptor to resemble that of gp185erbB-2Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancerEpidermal growth factor receptors in the oesophagus.Prognostic significance of the c-erbB-2 oncogene product in childhood medulloblastoma.Demonstration of ligand-dependent signaling by the erbB-3 tyrosine kinase and its constitutive activation in human breast tumor cells.An activated allele of the c-erbB-2 oncogene impairs kidney and lung function and causes early death of transgenic mice.Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1.Analogous regulatory sites within the alphaC-beta4 loop regions of ZAP-70 tyrosine kinase and AGC kinases.Two chimeric receptors of epidermal growth factor receptor and c-Ros that differ in their transmembrane domains have opposite effects on cell growth.ERBB-2 overexpression confers PI 3' kinase-dependent invasion capacity on human mammary epithelial cells.Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members.The juxtamembrane regions of the epidermal growth factor receptor and gp185erbB-2 determine the specificity of signal transduction.eps15, a novel tyrosine kinase substrate, exhibits transforming activity.Signaling through ShcA is required for transforming growth factor beta- and Neu/ErbB-2-induced breast cancer cell motility and invasion.Transformation of NIH 3T3 cells by overexpression of the normal coding sequence of the rat neu gene.Carboxyl-terminal deletion and point mutations decrease the transforming potential of the activated rat neu oncogene product.Eps15 is recruited to the plasma membrane upon epidermal growth factor receptor activation and localizes to components of the endocytic pathway during receptor internalization.EGFR kinase possesses a broad specificity for ErbB phosphorylation sites, and ligand increases catalytic-centre activity without affecting substrate binding affinity.Transmembrane signalling at the epidermal growth factor receptor. Positive regulation by the C-terminal phosphotyrosine residues.
P2860
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P2860
The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
The carboxy-terminal domains o ...... tion and transforming activity
@ast
The carboxy-terminal domains o ...... tion and transforming activity
@en
type
label
The carboxy-terminal domains o ...... tion and transforming activity
@ast
The carboxy-terminal domains o ...... tion and transforming activity
@en
prefLabel
The carboxy-terminal domains o ...... tion and transforming activity
@ast
The carboxy-terminal domains o ...... tion and transforming activity
@en
P2093
P2860
P356
P1476
The carboxy-terminal domains o ...... tion and transforming activity
@en
P2093
J H Pierce
P P Di Fiore
S A Aaronson
P2860
P304
P356
10.1128/MCB.10.6.2749
P407
P577
1990-06-01T00:00:00Z