PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS. - Wikidata - wikimedia - TriplyDB

PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS.

PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS.

http://www.wikidata.org/entity/Q36712792

about

Metabolic and hypoxic adaptation to anti-angiogenic therapy: a target for induced essentiality Tauroursodeoxycholic acid reduces the invasion of MDA-MB-231 cells by modulating matrix metalloproteinases 7 and 13 Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer Translational control of gene expression in the gonadotrope Proline biosynthesis is required for endoplasmic reticulum stress tolerance in Saccharomyces cerevisiae.Targeting hypoxia in the leukemia microenvironment BAY 87-2243, a novel inhibitor of hypoxia-induced gene activation, improves local tumor control after fractionated irradiation in a schedule-dependent manner in head and neck human xenografts Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy Applications and limitations of radiomics Two phases of disulfide bond formation have differing requirements for oxygen.eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies.Phosphorylation of Translation Initiation Factor 2-Alpha in Leishmania donovani under Stress Is Necessary for Parasite Survival.Mitochondrial dysfunction enhances cisplatin resistance in human gastric cancer cells via the ROS-activated GCN2-eIF2α-ATF4-xCT pathway.EGFR signaling and autophagy dependence for growth, survival, and therapy resistance.Watching the clock: endoplasmic reticulum-mediated control of circadian rhythms in cancer.The integrated stress response in lung disease.Translational regulator eIF2α in tumor.Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium.PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR)Methionine sulfoximine supplementation enhances productivity in GS-CHOK1SV cell lines through glutathione biosynthesis.Molecular mechanisms of mTOR regulation by stress Respiratory gases and the regulation of transcription.Novel Approaches to Apoptosis-Inducing Therapies.Emerging tale of UPR and cancer: an essentiality for malignancy.The unfolded protein response in glioblastomas: targetable or trouble?eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet.The secreted antigen, HP0175, of Helicobacter pylori links the unfolded protein response (UPR) to autophagy in gastric epithelial cells.Regulation of tumor-stroma interactions by the Unfolded Protein Response.Developmental competence of bovine early embryos depends on the coupled response between oxidative and endoplasmic reticulum stress.Recent insights into PERK-dependent signaling from the stressed endoplasmic reticulum.Investigation of radiomic signatures for local recurrence using primary tumor texture analysis in oropharyngeal head and neck cancer patients.EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition.Unfolded Protein Response of the Endoplasmic Reticulum in Tumor Progression and Immunogenicity.Activation of ER Stress-Dependent miR-216b Has a Critical Role in Salviamiltiorrhiza Ethanol-Extract-Induced Apoptosis in U266 and U937 Cells.The expression of epidermal growth factor-like domain 7 regulated by oxygen tension via hypoxia inducible factor (HIF)-1α activity.The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia.Inhibition of breast cancer cell growth by methyl pyropheophenylchlorin photodynamic therapy is mediated though endoplasmic reticulum stress-induced autophagy in vitro and vivo.Hypoxia and Selective Autophagy in Cancer Development and Therapy Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review

P2860

Q27025007-AE713C94-A5CD-4A7C-BF20-96D628862A81 Q28828990-41C558C3-1641-48F9-A845-F0962B9126B5 Q29248711-5964AB69-F719-4D91-A284-9DF8A1E3BBB3 Q33565770-6DB621ED-4838-49EF-BEE2-4628E8A5CA5C Q34283514-A0A41734-5E41-4FD6-BA0E-F4369A203F16 Q34401785-53169C47-2A1A-49B3-9E7E-4D9A7BC94DB8 Q34672437-CFFB201E-D948-4992-B425-2D12D4F8A72E Q34988108-5540B1DB-DEF6-4631-BBE4-4E582E2DAACD Q35912293-66C248DC-7B11-4BD2-BF39-5D699013E47B Q37052862-6ECC8DB5-8577-4884-AC3E-F5B384AB83F2 Q37343919-6201E114-8F49-417E-BEDA-D43CFA226D04 Q37445048-24FA246D-739D-4B0E-836F-D8793C486D6A Q37538574-A9F5BB09-B610-4427-8701-80C77F532E76 Q37687535-4FD99FD4-CD4E-4C89-A36C-DF97BCCF6F13 Q38171032-AE9F4981-1A24-4816-9F4C-68CBB8471A39 Q38184659-8A42CF98-C0EB-49E7-B4A3-9CEF83951DA2 Q38194164-C71993D9-01F8-4CF7-912B-89499365CDAD Q38194482-8C7FF9DB-4AEB-454C-B94C-25E9EC69E283 Q38263008-7034D6CC-87FB-4589-A56F-3EEA94259454 Q38644410-C6945A7F-BF30-4745-B2DD-62BC9C1DC0AA Q38735194-79AEC943-4128-4C0A-B585-A7780DD6E92B Q38866763-144684B4-3F1E-4AFB-80E0-EFDD55364F08 Q38913128-79A6378B-8D20-4EC4-83FF-DFCC39904EDF Q38936710-99DE39F1-C1D4-40FB-BED1-204BD5407917 Q38954615-338489AC-3959-46BA-92F5-EB1C91A6DA64 Q38970037-14982882-DEFC-4A26-AC40-F75ADE33F4D3 Q41195914-0A8C7DDC-3EE2-4D92-B713-E40899EC4560 Q41640600-1C3B45A2-4008-4371-A81F-72162F9847AA Q46556374-E410579B-A0A0-48CD-9410-787DA7DDAFD4 Q46910677-D057F337-8898-49D6-889B-E9D9B98A32B3 Q47388417-44A25925-97A2-4681-88DC-14547BDFBB45 Q47556834-034CD754-5D93-4502-9D61-679982C94D50 Q48150178-DA524922-EA97-40D4-93E1-FE0C58B1E54A Q50073383-FED54B3A-A5EA-41E2-81A4-A6F4A09A606D Q52718358-1746E203-D190-4163-80A9-659C83279496 Q54179282-4C2935C7-9CD6-4089-BA40-3A06F5E13EC5 Q54978893-13B11CE5-02BD-429E-B36B-E7C1CAF1AD9F Q55332387-FF4481F1-78DA-4747-AA6E-B5C0C9B9236D Q58754296-032DA2AC-1781-4B98-AD77-C2FD66CCF099 Q58800467-5B01C025-5025-4631-BDF5-D13C2904209A

P2860

PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS.

http://www.wikidata.org/entity/Q36712792

description

2013 nî lūn-bûn

@nan

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

2013年论文

@zh

2013年论文

@zh-cn

name

PERK/eIF2α signaling protects ...... is and protection against ROS.

@ast

PERK/eIF2α signaling protects ...... is and protection against ROS.

@en

type

label

PERK/eIF2α signaling protects ...... is and protection against ROS.

@ast

PERK/eIF2α signaling protects ...... is and protection against ROS.

@en

prefLabel

PERK/eIF2α signaling protects ...... is and protection against ROS.

@ast

PERK/eIF2α signaling protects ...... is and protection against ROS.

@en

P1433

Q36712792-D89C4247-B39D-4198-A211-88A9F149CFBA

P1476

Q36712792-7BCDCB23-36E6-4BBB-8442-5DD9DB035B6D

P2093

Q36712792-01BA06C7-8889-499E-B8A5-D37C63CCA87E

Q36712792-0DA636EE-BDED-4D7A-870C-382C4CB4F505

Q36712792-657A8E1B-BD64-4CA0-A354-FFBA2BEC07B8

Q36712792-8776063F-E457-41E1-8291-0F26A5D2AA42

Q36712792-87BB2073-A973-4540-BB94-5AEEE320B404

P2860

Q36712792-0C9389EC-7B9F-4200-AF15-E414618B9B33

Q36712792-1671ED67-0587-4568-9FC0-6DEFA20BE338

Q36712792-19A6F8F3-7C6E-4614-A43C-0D97E90BF91D

Q36712792-2196D7FC-4C27-4B82-B096-54D855D4512D

Q36712792-229CB2AA-D266-4E86-ACE2-68A9BC7DF68A

Q36712792-269BA739-B3A7-496F-A623-D7150212B335

Q36712792-26EDC833-9ACD-4265-816D-CC5A42743F90

Q36712792-39736C1A-E500-4DBD-95B6-42D2E0C1C9E6

Q36712792-468133BB-9031-4F68-B852-F48F9718C7BE

Q36712792-4F83DAE7-334E-4EED-9B42-3D360EC9BA99

P304

Q36712792-E650E5EA-8285-4D1B-B2DD-BEED69C684DE

P31

Q36712792-12147525-DF95-45AC-9663-4A2D4C5A8A85

P356

Q36712792-2D351AB9-1E1A-486E-B49E-17EE25A235C5

P407

Q36712792-3D776A3D-768C-4D5D-8274-2441A6B3B03C

P433

Q36712792-2F7BE8B0-E87B-465A-9D3B-733834E3D6A4

P478

Q36712792-63F9A7E9-02CB-495D-B447-3B7CA98EFDAF

P50

Q36712792-726C29E4-5911-424E-B34E-2ACBA1012218

Q36712792-E99FDDA8-3DF4-44DC-8ADE-51360F901C4C

Q36712792-EF294889-B148-4235-ABF6-A3BC88F9DE9C

Q36712792-F55BC9D2-FFB3-49A2-8302-855DEB74268C

P577

Q36712792-0256B4A9-4439-4A8D-A38E-0481C21822AB

P5875

Q36712792-1164105B-D19C-403E-B240-B2FBD18E2E1A

P698

Q36712792-E6DB45C7-625F-4BD4-B347-8B6918D36509

P921

Q36712792-19D08090-B5FC-4144-9A40-A4C10A5F558E

P932

Q36712792-2AFC0D90-0493-40F0-860A-BA743C628931

P356

PNAS.1210633110

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

PERK/eIF2α signaling protects ...... is and protection against ROS.

@en

P2093

Albert J van der Kogel

http://www.w3.org/2001/XMLSchema#string

Ludwig J Dubois

http://www.w3.org/2001/XMLSchema#string

Philippe Lambin

http://www.w3.org/2001/XMLSchema#string

Tom G Keulers

http://www.w3.org/2001/XMLSchema#string

Twan van den Beucken

http://www.w3.org/2001/XMLSchema#string

P2860

Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control.

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.

Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival

Targeting HIF-1 for cancer therapy

Signal integration in the endoplasmic reticulum unfolded protein response

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice.

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

Hypoxia--a key regulatory factor in tumour growth

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

P304

4622-4627

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.1210633110

http://www.w3.org/2001/XMLSchema#string

P407

P433

12

http://www.w3.org/2001/XMLSchema#string

P478

110

http://www.w3.org/2001/XMLSchema#string

P50

Bradly G. Wouters

Kasper M Rouschop

Marianne Koritzinsky

P577

2013-03-07T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

235886275

http://www.w3.org/2001/XMLSchema#string

P698

23471998

http://www.w3.org/2001/XMLSchema#string

P921

P932

3607059

http://www.w3.org/2001/XMLSchema#string