Selection against pathogenic mtDNA mutations in a stem cell population leads to the loss of the 3243A-->G mutation in blood
about
Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic cryptsGimap3 regulates tissue-specific mitochondrial DNA segregationTransmission of mitochondrial DNA diseases and ways to prevent them.Previous estimates of mitochondrial DNA mutation level variance did not account for sampling error: comparing the mtDNA genetic bottleneck in mice and humans.Late-onset Mitochondrial Cardiomyopathy Triggered by Anticancer TreatmentDoes mtDNA nucleoid organization impact aging?MtDNA segregation in heteroplasmic tissues is common in vivo and modulated by haplotype differences and developmental stage.Non-random mtDNA segregation patterns indicate a metastable heteroplasmic segregation unit in m.3243A>G cybrid cells.Segregation of mtDNA throughout human embryofetal development: m.3243A>G as a model systemNeutral mitochondrial heteroplasmy and the influence of aging.Mitochondrial nucleoids maintain genetic autonomy but allow for functional complementation.Extreme-Depth Re-sequencing of Mitochondrial DNA Finds No Evidence of Paternal Transmission in HumansMitochondrial DNA sequence characteristics modulate the size of the genetic bottleneckPreventing the transmission of pathogenic mitochondrial DNA mutations: Can we achieve long-term benefits from germ-line gene transfer?Metabolic plasticity in stem cell homeostasis and differentiation.Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck.Pathogenic mitochondrial DNA mutations are common in the general populationInduced pluripotent stem cells with a mitochondrial DNA deletionNucleoid autonomy: An underlying mechanism of mitochondrial genetics with therapeutic potentialMouse models of oxidative phosphorylation defects: powerful tools to study the pathobiology of mitochondrial diseases.The distribution of mitochondrial DNA heteroplasmy due to random genetic drift.Mitochondrial DNA genetics and the heteroplasmy conundrum in evolution and disease.The inheritance of pathogenic mitochondrial DNA mutations.Mitochondrial DNA transcription regulation and nucleoid organization.Insight into mammalian mitochondrial DNA segregation.mtDNA mutations variously impact mtDNA maintenance throughout the human embryofetal development.Whole blood genome-wide expression profiling and network analysis suggest MELAS master regulators.Intra-individual purifying selection on mitochondrial DNA variants during human oogenesis.Genetic Counselling for Maternally Inherited Mitochondrial Disorders.Tissue-specific modulation of mitochondrial DNA segregation by a defect in mitochondrial division.Prevalence of migraine in persons with the 3243A>G mutation in mitochondrial DNA.Do somatic mitochondrial DNA mutations contribute to Parkinson's disease?Gimap3: A foot-in-the-door to tissue-specific regulation of mitochondrial DNA genetics.Intracellular evolution of mitochondrial DNA (mtDNA) and the tragedy of the cytoplasmic commons.The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease.Roles of Mitochondrial DNA Mutations in Stem Cell Ageing.High frequency of migraine-only patients negative for the 3243 A>G tRNALeu mtDNA mutation in two MELAS families.Phenotypic heterogeneity in m.3243A>G mitochondrial disease: The role of nuclear factors.Anatomic & metabolic brain markers of the m.3243A>G mutation: A multi-parametric 7T MRI study.mtDNA heteroplasmy level and copy number indicate disease burden in m.3243A>G mitochondrial disease.
P2860
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P2860
Selection against pathogenic mtDNA mutations in a stem cell population leads to the loss of the 3243A-->G mutation in blood
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Selection against pathogenic m ...... he 3243A-->G mutation in blood
@ast
Selection against pathogenic m ...... he 3243A-->G mutation in blood
@en
type
label
Selection against pathogenic m ...... he 3243A-->G mutation in blood
@ast
Selection against pathogenic m ...... he 3243A-->G mutation in blood
@en
prefLabel
Selection against pathogenic m ...... he 3243A-->G mutation in blood
@ast
Selection against pathogenic m ...... he 3243A-->G mutation in blood
@en
P2860
P1476
Selection against pathogenic m ...... he 3243A-->G mutation in blood
@en
P2093
David C Samuels
Harsha Karur Rajasimha
P2860
P304
P356
10.1016/J.AJHG.2007.10.007
P407
P577
2008-02-01T00:00:00Z