The distribution of mitochondrial DNA heteroplasmy due to random genetic drift.
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Transmission of mitochondrial DNA diseases and ways to prevent them.Previous estimates of mitochondrial DNA mutation level variance did not account for sampling error: comparing the mtDNA genetic bottleneck in mice and humans.The strength and timing of the mitochondrial bottleneck in salmon suggests a conserved mechanism in vertebrates.Very low-level heteroplasmy mtDNA variations are inherited in humansStochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism.Segregation of mtDNA throughout human embryofetal development: m.3243A>G as a model systemAnalysis of the heteroplasmy level and transmitted features in hearing-loss pedigrees with mitochondrial 12S rRNA A1555G mutation.Selection on Mitochondrial Variants Occurs between and within Individuals in an Expanding Invasion.Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission.Preventing the transmission of pathogenic mitochondrial DNA mutations: Can we achieve long-term benefits from germ-line gene transfer?Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck.Mitochondrial DNA genetics and the heteroplasmy conundrum in evolution and disease.A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.Evolution of Cell-to-Cell Variability in Stochastic, Controlled, Heteroplasmic mtDNA Populations.The inheritance of pathogenic mitochondrial DNA mutations.Tissue-specific modulation of mitochondrial DNA segregation by a defect in mitochondrial division.Detecting heteroplasmy from high-throughput sequencing of complete human mitochondrial DNA genomes.No relationship found between point heteroplasmy in mitochondrial DNA control region and age range, sex and haplogroup in human hairs.A Population Phylogenetic View of Mitochondrial Heteroplasmy.Deep-Coverage MPS Analysis of Heteroplasmic Variants within the mtGenome Allows for Frequent Differentiation of Maternal Relatives.Closed-form stochastic solutions for non-equilibrium dynamics and inheritance of cellular components over many cell divisions.Fine Time Scaling of Purifying Selection on Human Nonsynonymous mtDNA Mutations Based on the Worldwide Population Tree and Mother-Child Pairs.Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations.
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P2860
The distribution of mitochondrial DNA heteroplasmy due to random genetic drift.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 30 October 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The distribution of mitochondrial DNA heteroplasmy due to random genetic drift.
@en
The distribution of mitochondrial DNA heteroplasmy due to random genetic drift.
@nl
type
label
The distribution of mitochondrial DNA heteroplasmy due to random genetic drift.
@en
The distribution of mitochondrial DNA heteroplasmy due to random genetic drift.
@nl
prefLabel
The distribution of mitochondrial DNA heteroplasmy due to random genetic drift.
@en
The distribution of mitochondrial DNA heteroplasmy due to random genetic drift.
@nl
P2860
P1476
The distribution of mitochondrial DNA heteroplasmy due to random genetic drift.
@en
P2093
David C Samuels
Passorn Wonnapinij
P2860
P304
P356
10.1016/J.AJHG.2008.10.007
P407
P577
2008-10-30T00:00:00Z